A predictive enrichment procedure to identify potential responders to a new therapy for randomized, comparative controlled clinical studies

Biometrics

Volumn 72, Issue 3, 2016, Pages 877-887

  Li, Junlong ^a   Zhao, Lihui ^b   Tian, Lu ^c   Cai, Tianxi ^a   Claggett, Brian ^d   Callegaro, Andrea ^e   Dizier, Benjamin ^e   Spiessens, Bart ^e   Ulloa Montoya, Fernando ^e   Wei, Lee Jen ^a  

^a HARVARD UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c STANFORD UNIVERSITY   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e GSK   (Belgium)

Author keywords

Cox model; Cross validation; Stratified medicine; Survival analysis; Therapy diagnostic co development

Indexed keywords

DIAGNOSIS; NUMERICAL METHODS;

CLINICAL STUDY; CO-DEVELOPMENT; COX MODEL; CROSS VALIDATION; DATA SET; PATIENT POPULATION; RISK BENEFITS; SCORING SYSTEMS; SURVIVAL ANALYSIS; THERAPY-DIAGNOSTIC CO-DEVELOPMENT;

PATIENT TREATMENT;

BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

BIOMETRY; CARDIOVASCULAR DISEASE; DATA SET; MEDICINE; MODEL VALIDATION; SUBPOPULATION; SURVIVAL;

CARDIOVASCULAR DISEASES; COMPUTER SIMULATION; HEART FAILURE; HUMAN; OUTCOME ASSESSMENT; PATIENT SELECTION; PROPORTIONAL HAZARDS MODEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SAMPLE SIZE; STANDARDS; STATISTICS AND NUMERICAL DATA; SURVIVAL ANALYSIS; THERAPY; TREATMENT OUTCOME;

ADRENERGIC BETA-ANTAGONISTS; CARDIOVASCULAR DISEASES; COMPUTER SIMULATION; HEART FAILURE; HUMANS; OUTCOME ASSESSMENT (HEALTH CARE); PATIENT SELECTION; PROPORTIONAL HAZARDS MODELS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK ASSESSMENT; SAMPLE SIZE; SURVIVAL ANALYSIS; THERAPEUTICS; TREATMENT OUTCOME;

EID: 85028275753     PISSN: None     EISSN: 15410420     Source Type: Journal    
DOI: 10.1111/biom.12461     Document Type: Article

References (33)