Antimicrobial effects of the combination of chlorhexidine and xylitol

British Dental Journal

Volumn 209, Issue 12, 2010, Pages 1-5

  Paula, Viviane Andrade Cancio ^a   Modesto, A ^b   Santos, K R N ^a   Gleiser, R ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDULATED FLUOROPHOSPHATE; ANTICARIES AGENT; CHLORHEXIDINE; CHLORHEXIDINE, THYMOL DRUG COMBINATION; FLUORIDE VARNISH; SWEETENING AGENT; THYMOL; TOPICAL ANTIINFECTIVE AGENT; XYLITOL;

ARTICLE; BACTERIAL LOAD; BIOFILM; CHEWING GUM; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG COMBINATION; DRUG EFFECT; FEMALE; FOLLOW UP; GEL; HUMAN; MALE; MICROBIOLOGY; RANDOMIZED CONTROLLED TRIAL; SALIVA; STREPTOCOCCUS MUTANS; TOOTH; TOOTH PLAQUE;

ACIDULATED PHOSPHATE FLUORIDE; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIAL LOAD; BIOFILMS; CARIOSTATIC AGENTS; CHEWING GUM; CHILD; CHLORHEXIDINE; DENTAL PLAQUE; DRUG COMBINATIONS; FEMALE; FLUORIDES, TOPICAL; FOLLOW-UP STUDIES; GELS; HUMANS; MALE; SALIVA; STREPTOCOCCUS MUTANS; SWEETENING AGENTS; THYMOL; TOOTH; XYLITOL;

EID: 85028122898     PISSN: 00070610     EISSN: 17417503     Source Type: Journal    
DOI: 10.1038/sj.bdj.2010.887     Document Type: Article

References (36)

1. Banas JA, Miller JD, Fuschino ME et al. Evidence that accumulation of mutants in a biofilm reflects natural selection rather than stress-induced adaptive mutation. Appl Environ Microbiol 2007; 73: 357-361.
2. Mattos Graner RO, Smith DJ, King WF, Mayer MP. Water insoluble glucan synthesis by mutans streptococcal strains correlates with caries incidence in 12 to 30 month old children. J Dent Res 2000; 79: 1371-1377.
3. Matthijs S, Adriaens PA. Chlorhexidine varnishes: a review. J Clin Periodontol 2002; 29: 1-8.
4. Petti S, Hausen H. Caries preventive effect of chlorhexidine gel applications among high risk children. Caries Res 2006; 40: 514-521.
5. Isokangas P, Soderling E, Pienihakkinen K, Alanen A. Occurrence of dental decay in children after maternal consumption of xylitol chewing gum, a follow up from 0to 5years of age. J Dent Res 2000; 79: 1885-1889.
6. Kuramitsu HK, Wang BY. Virulence properties of cariogenic bacteria. BMC Oral Health 2006; 6(Suppl 1): S11.
7. Napimoga MH, Hofling JF, Klein MI, Kamiya RU, Goncalves RB. Transmission, diversity and virulence factors of Streptococcus mutans genotypes. J Oral Sci 2005; 47: 59-64.
8. Glassman P, Anderson M, Jacobsen P et al. Practical protocols for the prevention of dental disease in community settings for people with special needs: the protocols. Spec Care Dentist 2003; 23: 160-164.
9. Rodrigues CR, Marquezan M, Barroso LP et al. Effect of chlorhexidine thymol varnish on caries lesion development in first permanent molars. J Clin Dent 2008; 19: 18-21.
10. Modesto A, Drake DR. Multiple exposures to chlorhexidine and xylitol: adhesion and biofilm formation by Streptococcus mutans. Curr Microbiol 2006; 52: 418-423.
11. Anderson M. Chlorhexidine and xylitol gum in caries prevention. Spec Care Dentist 2003; 23: 173-176.
12. Burt BA. The use of sorbitol and xylitol sweetened chewing gum in caries control. J Am Dent Assoc 2006; 137: 190-196.
13. Holgerson PL, Sjostrom I, Stecksen Blicks C, Twetman S. Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. Int J Paediatr Dent 2007; 17: 79-85.
14. Thaweboon S, Nakornchai S, Miyake Y et al. Remineralization of enamel subsurface lesions by xylitol chewing gum containing funoran and calcium hydrogenphosphate. Southeast Asian J Trop Med Public Health 2009; 40: 345-353.
15. Miyasawa-Hori H, Aizawa S, Takahashi N. Difference in the xylitol sensitivity of acid production among Streptococcus mutans strains and the biochemical mechanism. Oral Microbiol Immunol 2006; 21: 201-205.
16. Stecksén Blicks C, Holgerson PL, Twetman S. Effect of xylitol and xylitol fluoride lozenges on approximal caries development in high caries risk children. Int J Paediatr Dent 2008; 18: 170-177.
17. Twetman S. Consistent evidence to support the use of xylitol and sorbitol containing chewing gum to prevent dental caries. Evid Based Dent 2009; 10: 10-11.
18. Deng DM, Ten Cate JM, Crielaard W. The adaptive response of Streptococcus mutans towards oral care products: involvement of the ClpP serine protease. Eur J Oral Sci 2007; 115: 363-370.
19. Köhler B, Bratthall D. Practical method to facilitate estimation to Streptococcus mutans levels in saliva. J Clin Microbiol 1979; 9: 584-588.
20. Kimmel L, Tinanoff N. A modified mitis salivarius medium for a caries diagnostic test. Oral Microbiol Immunol 191; 6: 275-279.
21. Weber KA. Comparison of the effectiveness of three education interventions in the prevention of "early childhood caries" Iowa: Iowa University, 2003. Masters Thesis.
22. Ribeiro A, Souza IP. Relação entre biofilme, atividade de cárie e gengivite em crianças HIV+ Pesqui. Odontol Bras 2002; 16(2): 15-22.
23. Seminario A, Broukal Z, Ivancaková R. Mutans streptococci and the development of dental plaque. Prague Med Rep 2005; 106: 349-358.
24. Matsumoto-Nakano M, Fujita K, Ooshima T. Comparison of glucan binding proteins in cariogenicity of Streptococcus mutans. Oral Microbiol Immunol 2007; 22: 30-35.
25. Van Houte J. Role of microorganisms in caries aetiology. J Dent Res 1994; 73: 672-681.
26. Law V, Seow WK. A longitudinal study of 0.2% chlorhexidine gel for removal of mutans streptococci infection in preschool children. Aust Dent J 2007; 52: 26-32.
27. Decker EM, Maier G, Axmann D, Brecx M, von Ohle C. Effect of xylitol/chlorhexidine versus xylitol or chlorhexidine as single rinses on initial biofilm formation of cariogenic streptococci. Quintessence Int 2008; 39: 17-22.
28. Ribeiro LG, Hashizume LN, Maltz M. The effect of different formulations of chlorhexidine in reducing levels of mutans streptococci in the oral cavity: a systematic review of the literature. J Dent 2007; 35: 359-370.
29. Yoshida Y, Palmer RJ, Yang J, Kolenbrander PE, Cisar JO. Streptococcal receptor polysaccharides: recognition molecules for oral biofilm formation. BMC Oral Health 2006; 6(Suppl 1): S12.
30. Timmons SR, Harless JD, Hogan MM et al. Effect of an alcohol free, 1% chlorhexidine gel as an adjunct to a fluoridated dentifrice using an intraoral crown model. Caries Res 2007; 41: 190-197.
31. Zhang Q, Mulder J, Truin GJ, van Palenstein Helderman WH. Effect of 40% chlorhexidine varnish on mutans streptococci counts in pits and fissures of permanent first molars. J Dent 2007; 35: 588-592.
32. Haresaku S, Hanioka W, Tsutsui A, Yamamoto M, Chou T, Gunjishima Y. Long term effect of xylitol gum use on mutans streptococci in adults. Caries Res 2007; 41: 198-203.
33. Massoth D, Massoth G, Massoth IR, Laflamme L, Shi W, Hu C. The effect of xylitol on Streptococcus mutans in children. J Calif Dent Assoc 2006; 34: 231-234.
34. Assev S, Stig S, Scheie AA. Cariogenic traits in xylitol resistant and xylitol sensitive mutans streptococci. Oral Microbiol Immunol 2002; 17: 95-99.
35. Thorild I, Lindau B, Twetman S. Effect of maternal use of chewing gums containing xylitol, chlorhexidine or fluoride on mutans streptococci colonization in the mothers’ infant children. Oral Health Prev Dent 2003; 1: 53-57.
36. Featherstone JD. Delivery challenges for fluoride, chlorhexidine and xylitol. BMC Oral Health 2006; 6(Suppl 1): S8.