Red cell distribution width is associated with hemoglobin A1C elevation, but not glucose elevation

Journal of Diabetes and its Complications

Volumn 31, Issue 10, 2017, Pages 1544-1548

  Bao, Xue ^a   Wan, Min ^a   Gu, Yeqing ^a   Song, Yanqi ^b   Zhang, Qing ^a   Liu, Li ^a   Meng, Ge ^a   Wu, Hongmei ^a   Xia, Yang ^a   Shi, HongBin ^a   Su, Qian ^a   Fang, Liyun ^a   Yang, Huijun ^a   Yu, Fei ^a   Sun, Shaomei ^a   Wang, Xing ^a   Zhou, Ming ^a   Jia, Qiyu ^a   Song, Kun ^a   Wang, Guolin ^a   Yu, Ming ^a   Niu, Kaijun ^a   more..

^a TIANJIN MEDICAL UNIVERSITY   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cohort; Glucose; Glycated hemoglobin; Population; Red cell distribution width

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN A1C PROTEIN, HUMAN;

ADULT; ARTICLE; COHORT ANALYSIS; DIET RESTRICTION; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; MALE; MIDDLE AGED; NORMAL HUMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; RED BLOOD CELL DISTRIBUTION WIDTH; ANALYSIS; ASIAN CONTINENTAL ANCESTRY GROUP; ASYMPTOMATIC DISEASE; BLOOD; CELL AGING; CHINA; CYTOLOGY; ERYTHROCYTE; ERYTHROCYTE VOLUME; ETHNOLOGY; HEALTH STATUS; IMPAIRED GLUCOSE TOLERANCE; INCIDENCE; LONGITUDINAL STUDY; PATHOLOGY; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; SEX FACTOR;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; ASYMPTOMATIC DISEASES; BLOOD GLUCOSE; CELLULAR SENESCENCE; CHINA; COHORT STUDIES; ERYTHROCYTE VOLUME; ERYTHROCYTES; FEMALE; GLYCATED HEMOGLOBIN A; HEALTH STATUS; HUMANS; INCIDENCE; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PREDIABETIC STATE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS;

EID: 85028043136     PISSN: 10568727     EISSN: 1873460X     Source Type: Journal    
DOI: 10.1016/j.jdiacomp.2017.07.013     Document Type: Article

References (25)

1. Weiss, G., Goodnough, L.T., Anemia of chronic disease. N Engl J Med 352 (2005), 1011–1023, 10.1056/NEJMra041809.
2. Demirkol, S., Balta, S., Cakar, M., Unlu, M., Arslan, Z., Kucuk, U., Red cell distribution width: a novel inflammatory marker in clinical practice. Cardiol J, 20, 2013, 209, 10.5603/CJ.2013.0037.
3. Zalawadiya, S.K., Veeranna, V., Niraj, A., Pradhan, J., Afonso, L., Red cell distribution width and risk of coronary heart disease events. Am J Cardiol 106 (2010), 988–993, 10.1016/j.amjcard.2010.06.006.
4. Chen, P.C., Sung, F.C., Chien, K.L., Hsu, H.C., Su, T.C., Lee, Y.T., Red blood cell distribution width and risk of cardiovascular events and mortality in a community cohort in Taiwan. Am J Epidemiol 171 (2010), 214–220, 10.1093/aje/kwp360.
5. Tonelli, M., Sacks, F., Arnold, M., Moye, L., Davis, B., Pfeffer, M., et al. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation 117 (2008), 163–168, 10.1161/CIRCULATIONAHA.107.727545.
6. Malandrino, N., Wu, W.C., Taveira, T.H., Whitlatch, H.B., Smith, R.J., Association between red blood cell distribution width and macrovascular and microvascular complications in diabetes. Diabetologia 55 (2012), 226–235, 10.1007/s00125-011-2331-1.
7. Tsuboi, S., Miyauchi, K., Kasai, T., Ogita, M., Dohi, T., Miyazaki, T., et al. Impact of red blood cell distribution width on long-term mortality in diabetic patients after percutaneous coronary intervention. Circ J 77 (2013), 456–461.
8. Gang, L., Lifang, W., Association of the elevated red blood cell distribution width with the risk of developing diabetes mellitus. Intern Med 55 (2016), 1959–1965, 10.2169/internalmedicine.55.5956.
9. Engstrom, G., Smith, J.G., Persson, M., Nilsson, P.M., Melander, O., Hedblad, B., Red cell distribution width, haemoglobin A1c and incidence of diabetes mellitus. J Intern Med 276 (2014), 174–183, 10.1111/joim.12188.
10. Lippi, G., Targher, G., Salvagno, G.L., Guidi, G.C., Increased red blood cell distribution width (RDW) is associated with higher glycosylated hemoglobin (HbA1c) in the elderly. Clin Lab 60 (2014), 2095–2098.
11. Veeranna, V., Zalawadiya, S.K., Panaich, S.S., Ramesh, K., Afonso, L., The association of red cell distribution width with glycated hemoglobin among healthy adults without diabetes mellitus. Cardiology 122 (2012), 129–132, 10.1159/000339225.
12. American, D.A., Diagnosis and classification of diabetes mellitus. Diabetes Care 37 (2014), S81–90, 10.2337/dc14-S081.
13. Gu, Y., Li, H., Bao, X., Zhang, Q., Liu, L., Meng, G., et al. The relationship between thyroid function and the prevalence of type 2 diabetes mellitus in euthyroid subjects. J Clin Endocrinol Metab 102 (2017), 434–442, 10.1210/jc.2016-2965.
14. Higgins, T., HbA(1c)—an analyte of increasing importance. Clin Biochem 45 (2012), 1038–1045, 10.1016/j.clinbiochem.2012.06.006.
15. Patel, H.H., Patel, H.R., Higgins, J.M., Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease. Am J Hematol 90 (2015), 422–428, 10.1002/ajh.23982.
16. Cohen, R.M., Franco, R.S., Khera, P.K., Smith, E.P., Lindsell, C.J., Ciraolo, P.J., et al. Red cell life span heterogeneity in hematologically normal people is sufficient to alter HbA1c. Blood 112 (2008), 4284–4291, 10.1182/blood-2008-04-154112.
17. Singh, D.K., Winocour, P., Farrington, K., Erythropoietic stress and anemia in diabetes mellitus. Nat Rev Endocrinol 5 (2009), 204–210, 10.1038/nrendo.2009.17.
18. Virtue, M.A., Furne, J.K., Nuttall, F.Q., Levitt, M.D., Relationship between GHb concentration and erythrocyte survival determined from breath carbon monoxide concentration. Diabetes Care 27 (2004), 931–935.
19. Meyer, C., Pimenta, W., Woerle, H.J., Van Haeften, T., Szoke, E., Mitrakou, A., et al. Different mechanisms for impaired fasting glucose and impaired postprandial glucose tolerance in humans. Diabetes Care 29 (2006), 1909–1914, 10.2337/dc06-0438.
20. Festa, A., D'Agostino, R. Jr., Hanley, A.J., Karter, A.J., Saad, M.F., Haffner, S.M., Differences in insulin resistance in nondiabetic subjects with isolated impaired glucose tolerance or isolated impaired fasting glucose. Diabetes 53 (2004), 1549–1555.
21. Misra, S., Hancock, M., Meeran, K., Dornhorst, A., Oliver, N.S., HbA1c: an old friend in new clothes. Lancet 377 (2011), 1476–1477, 10.1016/S0140-6736(10)61858-2.
22. English, E., Idris, I., Smith, G., Dhatariya, K., Kilpatrick, E.S., John, W.G., The effect of anaemia and abnormalities of erythrocyte indices on HbA1c analysis: a systematic review. Diabetologia 58 (2015), 1409–1421, 10.1007/s00125-015-3599-3.
23. Jansen, H., Stolk, R.P., Nolte, I.M., Kema, I.P., Wolffenbuttel, B.H., Snieder, H., Determinants of HbA1c in nondiabetic Dutch adults: genetic loci and clinical and lifestyle parameters, and their interactions in the Lifelines Cohort Study. J Intern Med 273 (2013), 283–293, 10.1111/joim.12010.
24. Fizelova, M., Stancakova, A., Lorenzo, C., Haffner, S.M., Cederberg, H., Kuusisto, J., et al. Glycated hemoglobin levels are mostly dependent on nonglycemic parameters in 9398 Finnish men without diabetes. J Clin Endocrinol Metab 100 (2015), 1989–1996, 10.1210/jc.2014-4121.
25. Liu, S., Hempe, J.M., McCarter, R.J., Li, S., Fonseca, V.A., Association between Inflammation and Biological Variation in Hemoglobin A1c in U.S. Nondiabetic Adults. J Clin Endocrinol Metab 100 (2015), 2364–2371, 10.1210/jc.2014-4454.