Hypothalamic inflammation in human obesity is mediated by environmental and genetic factors

Diabetes

Volumn 66, Issue 9, 2017, Pages 2407-2415

  Kreutzer, Carina ^a   Peters, Sönke ^a   Schulte, Dominik M ^a   Fangmann, Daniela ^a   Türk, Kathrin ^a   Wolff, Stephan ^a   Van Eimeren, Thilo ^b   Ahrens, Markus ^a   Beckmann, Jan ^a   Schafmayer, Clemens ^a   Becker, Thomas ^a   Kerby, Tina ^a   Rohr, Axel ^a   Riedel, Christian ^a   Heinsen, Femke Anouska ^a   Degenhardt, Frauke ^a   Franke, Andre ^a   Rosenstiel, Philip ^a   Zubek, Nana ^a   Henning, Christian ^a   Freitag Wolf, Sandra ^a   Dempfle, Astrid ^a   Psilopanagioti, Aristea ^c   Petrou Papadaki, Helen ^c   Lenk, Lennart ^a   Jansen, Olav ^a   Schreiber, Stefan ^a   Laudes, Matthias ^a   more..

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF COLOGNE   (Germany)

^c UNIVERSITY OF PATRAS   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; RNA 16S;

ADULT; BACTERIUM; CASE CONTROL STUDY; CLASSIFICATION; DIAGNOSTIC IMAGING; FEMALE; GASTROINTESTINAL TRACT; GENETIC EPIGENESIS; GENETICS; HUMAN; HYPERTRIGLYCERIDEMIA; HYPOTHALAMUS; INFLAMMATION; INSULIN RESISTANCE; MALE; METABOLISM; MICROBIOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PHYSIOLOGY;

ADULT; BACTERIA; BIOMARKERS; CASE-CONTROL STUDIES; EPIGENESIS, GENETIC; FEMALE; GASTROINTESTINAL TRACT; HUMANS; HYPERTRIGLYCERIDEMIA; HYPOTHALAMUS; INFLAMMATION; INSULIN RESISTANCE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OBESITY; RNA, RIBOSOMAL, 16S;

EID: 85028035580     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db17-0067     Document Type: Article

References (34)

1. Vogt MC, Brüning JC. CNS insulin signaling in the control of energy homeostasis and glucose metabolism-from embryo to old age. Trends Endocrinol Metab 2013;24:76-84
2. Farooqi IS, O'Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009;89:980S-984S
3. Farooqi IS, Keogh JM, Yeo GS, Lank EJ, Cheetham T, O'Rahilly S. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Engl J Med 2003;348:1085-1095
4. Schulte DM, Müller N, Neumann K, et al. Pro-inflammatory wnt5a and antiinflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. PLoS One 2012;7:e32437
5. Bilkovski R, Schulte DM, Oberhauser F, et al. Adipose tissue macrophages inhibit adipogenesis of mesenchymal precursor cells via wnt-5a in humans. Int J Obes 2011;35:1450-1454
6. Cawthorn WP, Heyd F, Hegyi K, Sethi JK. Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway. Cell Death Differ 2007;14:1361-1373
7. De Souza CT, Araujo EP, Bordin S, et al. Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus. Endocrinology 2005;146:4192-4199
8. Valdearcos M, Robblee MM, Benjamin DI, Nomura DK, Xu AW, Koliwad SK. Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function. Cell Reports 2014;9:2124-2138
9. Thaler JP, Yi CX, Schur EA, et al. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest 2012;122:153-162
10. Grayson BE, Levasseur PR, Williams SM, Smith MS, Marks DL, Grove KL. Changes in melanocortin expression and inflammatory pathways in fetal offspring of nonhuman primates fed a high-fat diet. Endocrinology 2010;151:1622-1632
11. Schur EA, Melhorn SJ, Oh SK, et al. Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans. Obesity (Silver Spring) 2015;23:2142-2148
12. Bertholdo D, Watcharakorn A, Castillo M. Brain proton magnetic resonance spectroscopy: introduction and overview. Neuroimaging Clin N Am 2013;23: 359-380
13. Oz G, Alger JR, Barker PB, et al.; MRS Consensus Group. Clinical proton MR spectroscopy in central nervous system disorders. Radiology 2014;270:658-679
14. Heinsen FA, Fangmann D, Müller N, et al. Beneficial effects of a dietary weight loss intervention on human gut microbiome diversity and metabolism are not sustained during weight maintenance. Obes Facts 2016;9:379-391
15. Degenhardt F, Niklowitz P, Szymczak S, et al. Genome-wide association study of serum coenzyme Q10 levels identifies susceptibility loci linked to neuronal diseases. Hum Mol Genet 2016;25:2881-2891
16. R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria, R Foundation for Statistical Computing, 2015
17. Purcell S, Neale B, Todd-Brown K, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81: 559-575
18. Best DJ, Roberts DE. Algorithm AS 89: the upper tail probabilities of spearman's rho. Appl Stat 1975;24:377-379
19. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 1990;215:403-410
20. Schulz M, Hoffmann K, Weikert C, Nöthlings U, Schulze MB, Boeing H. Identification of a dietary pattern characterized by high-fat food choices associated with increased risk of breast cancer: the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Br J Nutr 2008; 100:942-946
21. Fischer J, Koch L, Emmerling C, et al. Inactivation of the Fto gene protects from obesity. Nature 2009;458:894-898
22. Wittling W, Block A, Genzel S, Schweiger E. Hemisphere asymmetry in parasympathetic control of the heart. Neuropsychologia 1998;36:461-468
23. Briellmann RS, Kalnins RM, Berkovic SF, Jackson GD. Hippocampal pathology in refractory temporal lobe epilepsy: T2-weighted signal change reflects dentate gliosis. Neurology 2002;58:265-271
24. McNay DE, Briaņon N, Kokoeva MV, Maratos-Flier E, Flier JS. Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest 2012;122:142-152
25. Kratz M, Hagman DK, Kuzma JN, et al. Improvements in glycemic control after gastric bypass occur despite persistent adipose tissue inflammation. Obesity (Silver Spring) 2016;24:1438-1445
26. Furuya CK Jr, de Oliveira CP, de Mello ES, et al. Effects of bariatric surgery on nonalcoholic fatty liver disease: preliminary findings after 2 years. J Gastroenterol Hepatol 2007;22:510-514
27. Müller N, Schulte DM, Türk K, et al. IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans. J Lipid Res 2015;56:1034-1042
28. Offenbacher S, Divaris K, Barros SP, et al. Genome-wide association study of biologically informed periodontal complex traits offers novel insights into the genetic basis of periodontal disease. Hum Mol Genet 2016;25:2113-2129
29. Zhang X, Wang H, Yin P, Fan H, Sun L, Liu Y. Flaxseed oil ameliorates alcoholic liver disease via anti-inflammation and modulating gut microbiota in mice. Lipids Health Dis 2017;16:44
30. Shalley S, Pradip Kumar S, Srinivas TN, Suresh K, Anil Kumar P. Marinilabilia nitratireducens sp. nov., a lipolytic bacterium of the family Marinilabiliaceae isolated from marine solar saltern. Antonie van Leeuwenhoek 2013;103:519-525
31. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature 2012;489:220-230
32. Claesson MJ, Jeffery IB, Conde S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature 2012;488:178-184
33. Lasaga M, Debeljuk L, Durand D, Scimonelli TN, Caruso C. Role of alphamelanocyte stimulating hormone and melanocortin 4 receptor in brain inflammation. Peptides 2008;29:1825-1835
34. Wang J, Thingholm LB, Skieceviciene J, et al. Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota. Nat Genet 2016;48:1396-1406