Colonic Microbiota Encroachment Correlates With Dysglycemia in Humans

Cellular and Molecular Gastroenterology and Hepatology

Volumn 4, Issue 2, 2017, Pages 205-221

  Chassaing, Benoit ^a   Raja, Shreya M ^b,c   Lewis, James D ^d   Srinivasan, Shanthi ^b,c   Gewirtz, Andrew T ^a,b  

^a GEORGIA STATE UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Metabolic Syndrome; Microbiota; Mucus Layer

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C;

ADULT; AGED; ARTICLE; BACTERIAL COLONIZATION; BODY MASS; CANCER SCREENING; CLINICAL ARTICLE; COLON BIOPSY; COLON EPITHELIUM; COLON FLORA; COLONOSCOPY; CONFOCAL MICROSCOPY; DISEASE ASSOCIATION; DYSGLYCEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; HUMAN TISSUE; MALE; MIDDLE AGED; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 85028014497     PISSN: None     EISSN: 2352345X     Source Type: Journal    
DOI: 10.1016/j.jcmgh.2017.04.001     Document Type: Article

References (25)

1. Hooper, L.V., Macpherson, A.J., Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol 10 (2010), 159–169.
2. Chassaing, B., Darfeuille-Michaud, A., The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140 (2011), 1720–1728.
3. Xavier, R.J., Podolsky, D.K., Unravelling the pathogenesis of inflammatory bowel disease. Nature 448 (2007), 427–434.
4. Frank, D.N., St Amand, A.L., Feldman, R.A., Boedeker, E.C., Harpaz, N., Pace, N.R., Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 104 (2007), 13780–13785.
5. Gevers, D., Kugathasan, S., Denson, L.A., Vazquez-Baeza, Y., Van Treuren, W., Ren, B., et al. The treatment-naive microbiome in new-onset Crohn's disease. Cell Host Microbe 15 (2014), 382–392.
6. Johansson, M.E., Phillipson, M., Petersson, J., Velcich, A., Holm, L., Hansson, G.C., The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Proc Natl Acad Sci U S A 105 (2008), 15064–15069.
7. Swidsinski, A., Loening-Baucke, V., Herber, A., Mucosal flora in Crohn's disease and ulcerative colitis: an overview. J Physiol Pharmacol 60:Suppl 6 (2009), 61–71.
8. Vijay-Kumar, M., Aitken, J.D., Carvalho, F.A., Cullender, T.C., Mwangi, S., Srinivasan, S., Knight, R., Ley, R.E., Gewirtz, A.T., Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328 (2010), 228–231.
9. Caricilli, A.M., Picardi, P.K., de Abreu, L.L., Ueno, M., Prada, P.O., Ropelle, E.R., Hirabara, S.M., Castoldi, Â., Vieira, P., Camara, N.O., Curi, R., Carvalheira, J.B., Saad, M.J., Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol, 9, 2011, e1001212.
10. Henao-Mejia, J., Elinav, E., Jin, C., Hao, L., Mehal, W.Z., Strowig, T., Thaiss, C.A., Kau, A.L., Eisenbarth, S.C., Jurczak, M.J., Camporez, J.P., Shulman, G.I., Gordon, J.I., Hoffman, H.M., Flavell, R.A., Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482 (2012), 179–185.
11. Etienne-Mesmin, L., Vijay-Kumar, M., Gewirtz, A.T., Chassaing, B., Hepatocyte toll-like receptor 5 promotes bacterial clearance and protects mice against high-fat diet–induced liver disease. Cell Mol Gastroenterol Hepatol 2 (2016), 584–604.
12. Chassaing, B., Ley, R.E., Gewirtz, A.T., Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice. Gastroenterology 147 (2014), 1363–1377.
13. Chassaing, B., Koren, O., Goodrich, J.K., Poole, A.C., Srinivasan, S., Ley, R.E., Gewirtz, A.T., Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 519 (2015), 92–96.
14. Johansson, M.E., Hansson, G.C., Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with FISH. Methods Mol Biol 842 (2012), 229–235.
15. Furman, B.L., Streptozotocin-induced diabetic models in mice and rats. Curr Protoc Pharmacol, 70, 2015, 547.
16. Cavalcante-Silva, L.H., Galvao, J.G., da Silva, J.S., de Sales-Neto, J.M., Rodrigues-Mascarenhas, S., Obesity-driven gut microbiota inflammatory pathways to metabolic syndrome. Front Physiol, 6, 2015, 341.
17. Greenhill, C., Obesity: gut microbiota, host genetics and diet interact to affect the risk of developing obesity and the metabolic syndrome. Nat Rev Endocrinol, 11, 2015, 630.
18. Ussar, S., Griffin, N.W., Bezy, O., Fujisaka, S., Vienberg, S., Softic, S., Deng, L., Bry, L., Gordon, J.I., Kahn, C.R., Interactions between gut microbiota, host genetics and diet modulate the predisposition to obesity and metabolic syndrome. Cell Metab 22 (2015), 516–530.
19. Festi, D., Schiumerini, R., Eusebi, L.H., Marasco, G., Taddia, M., Colecchia, A., Gut microbiota and metabolic syndrome. World J Gastroenterol 20 (2014), 16079–16094.
20. Chassaing, B., Gewirtz, A.T., Gut microbiota, low-grade inflammation, and metabolic syndrome. Toxicol Pathol 42 (2014), 49–53.
21. Hotamisligil, G.S., Inflammation and metabolic disorders. Nature 444:7121 (2006), 860–867.
22. Gregor, M.F., Hotamisligil, G.S., Inflammatory mechanisms in obesity. Annu Rev Immunol 29 (2011), 415–445.
23. Chassaing, B., Gewirtz, A.T., Has provoking microbiota aggression driven the obesity epidemic?. Bioessays 38 (2016), 122–128.
24. Zou, J., Chassaing, B., Gewirtz, A.T., Dietary fiber protect against high-fat diet-induced metabolic syndrome through MyD88-mediated IL-22 production that reduces microbiota encroachment. Presented at the DDW meeting, 2017.
25. Garber, M.E., Saldanha, A., Parker, J.S., Jones, W.D., Kaukinen, K., Laurila, K., Lähdeaho, M.L., Khatri, P., Khosla, C., Adelman, D.C., Mäki, M., B cells correlate with the extent of gluten-induced intestinal injury in celiac disease. Cell Mol Gastroenterol Hepatol, 2017.