Cessation of donepezil is associated with clinical decline in patients with moderate-to-severe Alzheimer's disease compared to continuation of donepezil or addition or substitution of memantine

Evidence-Based Medicine

Volumn 18, Issue 2, 2013, Pages 62-63

  Tariot, Pierre N ^a  

^a BANNER ALZHEIMER S INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DONEPEZIL; MEMANTINE; PLACEBO;

ADD ON THERAPY; ALZHEIMER DISEASE; BEHAVIOR; CLINICAL DECISION MAKING; CLINICAL PROTOCOL; COGNITION; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DOUBLE BLIND PROCEDURE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FOLLOW UP; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MULTICENTER STUDY; NOTE; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL; SAMPLE SIZE;

EID: 85027956100     PISSN: 13565524     EISSN: 14736810     Source Type: Journal    
DOI: 10.1136/eb-2012-100722     Document Type: Note

References (10)

1. Feldman H, Gauthier S, Hecker J, et al A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology 2001;57:613-20.
2. Erratuma, Neurology 2001;57:2153.
3. Winblad B, Kilander L, Eriksson S, et al Donepezil in patients with severe Alzheimer's disease: double-blind, parallelgroup, placebo-controlled study. Lancet 2006;367:1057-65.
4. Errata, Lancet 2006;367:1980;368:1650.
5. Black SE, Doody R, Li H, et al Donepezil preserves cognition and global function in patients with severe Alzheimer disease. Neurology 2007;69:459-69.
6. Winblad B, Poritis N. Memantine in severe dementia: results of the 9M-Best Study (benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiatry 1999;14:135-46.
7. Tariot PN, Farlow MR, Grossberg GT, et al Memantine in patients with moderate to severe Alzheimer's disease already receiving donepezil. JAMA 2004;291:317-24.
8. clinicaltrials.gov http://clinicaltrials.gov/ct2/show/study/NCT00322153
9. Van Dyck CH, Tariot PN, Meyers B, et al A 24-week randomized, controlled trial of memantine in patients with moderate to severe Alzheimer's disease. Alzheimer Dis Assoc Disord 2007;21:136-43.
10. Porsteinsson AP, Grossberg GT, Mintzer J, et al Memantine treatment in patients with mild to moderate Alzheimer's disease already receiving a cholinesterase inhibitor: a randomized, double-blind placebo-controlled trial. Curr Alzheimer Res 2008;5:83-9.