Duration of wheezy episodes in early childhood is independent of the microbial trigger

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 5, 2015, Pages 1208-1214.e5

  Carlsson, Christian J ^a   Vissing, Nadja H ^a   Sevelsted, Astrid ^a   Johnston, Sebastian L ^b   Bønnelykke, Klaus ^a   Bisgaard, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

pediatrics; Respiratory tract infections; wheezy episodes

Indexed keywords

ARTICLE; ASTHMA; BACTERIAL INFECTION; BACTERIUM; CHILD; CLINICAL EXAMINATION; COHORT ANALYSIS; CONTROLLED STUDY; CORONAVIRIDAE; DISEASE DURATION; FEMALE; FOLLOW UP; HAEMOPHILUS INFLUENZAE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; MORAXELLA CATARRHALIS; NONHUMAN; PICORNAVIRIDAE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT ASPIRATION PROCEDURE; RESPIRATORY TRACT INFECTION; RHINOVIRUS; SEASONAL VARIATION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; SUMMER; VIRUS; VIRUS INFECTION; WHEEZING; WINTER; ABNORMAL RESPIRATORY SOUND; BACTERIAL INFECTIONS; DENMARK; INFANT; NEWBORN; PATHOPHYSIOLOGY; RESPIRATORY TRACT INFECTIONS; TIME; VIRUS DISEASES;

ASTHMA; BACTERIAL INFECTIONS; CHILD, PRESCHOOL; DENMARK; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MALE; PROSPECTIVE STUDIES; RESPIRATORY SOUNDS; RESPIRATORY TRACT INFECTIONS; TIME FACTORS; VIRUS DISEASES;

EID: 85027953805     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.05.003     Document Type: Article

References (25)

1. Johnston, S.L., Pattemore, P.K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ 310 (1995), 1225–1229.
2. Rakes, G.P., Arruda, E., Ingram, J.M., Hoover, G.E., Zambrano, J.C., Hayden, F.G., et al. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses. Am J Respir Crit Care Med 159 (1999), 785–790.
3. Kusel, M.M., de Klerk, N.H., Holt, P.G., Kebadze, T., Johnston, S.L., Sly, P.D., Role of respiratory viruses in acute upper and lower respiratory tract illness in the first year of life: a birth cohort study. Pediatr Infect Dis J 25 (2006), 680–686.
4. 2LEN-DARE systematic review. Allergy 66 (2011), 458–468.
5. Bisgaard, H., Hermansen, M.N., Bønnelykke, K., Stokholm, J., Baty, F., Skytt, N.L., et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ, 341, 2010, c4978.
6. Jartti, T., Lehtinen, P., Vuorinen, T., Osterback, R., van den Hoogen, B., Osterhaus, A.D., et al. Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children. Emerg Infect Dis 10 (2004), 1095–1101.
7. Calışkan, M., Bochkov, Y.A., Kreiner-Møller, E., Bønnelykke, K., Stein, M.M., Du, G., et al. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med 368 (2013), 1398–1407.
8. Bisgaard, H., The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. Ann Allergy Asthma Immunol 93 (2004), 381–389.
9. Bisgaard, H., Hermansen, M.N., Loland, L., Halkjaer, L.B., Buchvald, F., Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 354 (2006), 1998–2005.
10. Bisgaard, H., Hermansen, M.N., Buchvald, F., Loland, L., Halkjaer, L.B., Bønnelykke, K., et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 357 (2007), 1487–1495.
11. Sørensen, M., Bisgaard, H., Stage, M., Loft, S., Biomarkers of exposure to environmental tobacco smoke in infants. Biomarkers 12 (2007), 38–46.
12. Tan, W.C., Xiang, X., Qiu, D., Ng, T.P., Lam, S.F., Hegele, R.G., Epidemiology of respiratory viruses in patients hospitalized with near-fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease. Am J Med 115 (2003), 272–277.
13. Olenec, J.P., Kim, W.K., Lee, W.M., Vang, F., Pappas, T.E., Salazar, L.E., et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol 125 (2010), 1001–1006.e1.
14. Kocevar, V.S., Bisgaard, H., Jönsson, L., Valovirta, E., Kristensen, F., Yin, D.D., et al. Variations in pediatric asthma hospitalization rates and costs between and within Nordic countries. Chest 125 (2004), 1680–1684.
15. Bisgaard, H., Swern, A.S., Knorr, B., “To wheeze or not to wheeze”: that is not the question—the sequel. J Allergy Clin Immunol 130 (2012), 531–532.
16. Skytt, N., Bønnelykke, K., Bisgaard, H., “To wheeze or not to wheeze”: that is not the question. J Allergy Clin Immunol 130 (2012), 403–407.e5.
17. Busse, W.W., Lemanske, R.F., Gern, J.E., Role of viral respiratory infections in asthma and asthma exacerbations. Lancet 376 (2010), 826–834.
18. Bisgaard, H., The Copenhagen Prospective Study on Asthma in Childhood (COPSAC): design, rationale, and baseline data from a longitudinal birth cohort study. Ann Allergy Asthma Immunol 93 (2004), 381–389.
19. Bisgaard, H., Hermansen, M.N., Bønnelykke, K., Stokholm, J., Baty, F., Skytt, N.L., et al. Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study. BMJ, 341, 2010, c4978.
20. Bisgaard, H., Hermansen, M.N., Buchvald, F., Loland, L., Halkjaer, L.B., Bønnelykke, K., et al. Childhood asthma after bacterial colonization of the airway in neonates. N Engl J Med 357 (2007), 1487–1495.
21. American Society for Microbiology. Manual of clinical microbiology. 7th ed., 1999, ASM Press, Washington (DC), 1773.
22. Paganelli, R., Ansotegui, I.J., Sastre, J., Lange, C.E., Roovers, M.H., de Groot, H., et al. Specific IgE antibodies in the diagnosis of atopic disease. Clinical evaluation of a new in vitro test system, UniCAP, in six European allergy clinics. Allergy 53 (1998), 763–768.
23. Bisgaard, H., Simpson, A., Palmer, C.N.A., Bønnelykke, K., McLean, I., Mukhopadhyay, S., et al. Gene-environment interaction in the onset of eczema in infancy: filaggrin loss-of-function mutations enhanced by neonatal cat exposure. PLoS Med, 5, 2008, e131.
24. Bisgaard, H., Li, N., Bonnelykke, K., Chawes, B.L., Skov, T., Paludan-Müller, G., et al. Reduced diversity of the intestinal microbiota during infancy is associated with increased risk of allergic disease at school age. J Allergy Clin Immunol 128 (2011), 646–652 e1-5.
25. Bisgaard, H., Hermansen, M.N., Loland, L., Halkjaer, L.B., Buchvald, F., Intermittent inhaled corticosteroids in infants with episodic wheezing. N Engl J Med 354 (2006), 1998–2005.