Tacrolimus exposure after liver transplantation in randomized controlled trials: Too much for too long

American Journal of Transplantation

Volumn 13, Issue 5, 2013, Pages 1371-1372

  Rodriguez Peralvarez M ^a,b   Germani, G ^a   Darius, T ^c   Lerut, J ^c   Tsochatzis, E ^a   De La Mata, M ^b   Burroughs, A K ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

EVEROLIMUS; TACROLIMUS;

DRUG EXPOSURE; GLOMERULUS FILTRATION RATE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LETTER; LIVER TRANSPLANTATION; PATIENT SAFETY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC);

EID: 85027950521     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12216     Document Type: Letter

References (5)

1. De Simone P, Nevens F, De Carlis L, et al. Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: A randomized controlled trial. Am J Transplant 2012; 12: 3008-3020.
2. Rodriguez-Peralvarez M, Germani G, Papastergiou V, et al. Early tacrolimus exposure after liver transplantation: Relationship with moderate/severe acute rejection and long term outcome. J Hepatol 2013; 58: 262-270.
3. Rodriguez-Perálvarez M, Germani G, Darius T, Lerut J, Tsochatzis E, Burroughs AK., Tacrolimus trough levels, rejection and renal impairment in liver transplantation: A systematic review and meta-analysis. Am J Transplant 2013; 13: 239.
4. Ojo AO, Held PJ, Port FK, et al. Chronic renal failure after transplantation of a nonrenal organ. N Engl J Med 2003; 349: 931-940.
5. Lerut J, Mathys J, Verbaandert C, et al. Tacrolimus monotherapy in liver transplantation: One-year results of a prospective, randomized, double-blind, placebo-controlled study. Ann Surg 2008; 248: 956-967.