Metabolic fate, mass spectral fragmentation, detectability, and differentiation in urine of the benzofuran designer drugs 6-APB and 6-MAPB in comparison to their 5-isomers using GC-MS and LC-(HR)-MSn techniques

Analytical and Bioanalytical Chemistry

Volumn 407, Issue 12, 2021, Pages

  Welter, Jessica ^a   Brandt, Simon D ^b   Kavanagh, Pierce ^c   Meyer, Markus R ^a   Maurer, Hans H ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c ST JAMES S HOSPITAL   (Ireland)

Author keywords

6 APB; 6 MAPB; Designer drugs; GC MS; LC (HR) MSn; Metabolism

Indexed keywords

BIOMOLECULES; CHEMICAL MODIFICATION; DRUG PRODUCTS; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHASE SEPARATION; RATS;

6-APB; 6-MAPB; DESIGNER DRUGS; GC-MS; LIQUID CHROMATOGRAPHY-HIGH RESOLUTION MASS SPECTROMETRIES; MASS SPECTRAL FRAGMENTATION; SCREENING APPROACHES; SOLID-PHASE EXTRACTION;

DRUG DOSAGE;

6-(2-AMINOPROPYL)BENZOFURAN; BENZOFURAN DERIVATIVE; CYP1A2 PROTEIN, HUMAN; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450 1A2; CYTOCHROME P450 2D6; CYTOCHROME P450 3A; DESIGNER DRUG; N-METHYL-6-(2-AMINOPROPYL)BENZOFURAN; PROPYLAMINE;

ANIMAL; COMPARATIVE STUDY; DRUG EFFECTS; DRUG INACTIVATION; HUMAN; ISOMERISM; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; METABOLISM; PROCEDURES; SOLID PHASE EXTRACTION; URINE; WISTAR RAT;

ANIMALS; BENZOFURANS; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 CYP3A; DESIGNER DRUGS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; INACTIVATION, METABOLIC; ISOMERISM; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; PROPYLAMINES; RATS, WISTAR; SOLID PHASE EXTRACTION;

EID: 85027950504     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-015-8552-2     Document Type: Article

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