An intervention study of oral versus intravenous hypertonic saline administration in ultramarathon runners with exercise-associated hyponatremia: A preliminary randomized trial

Clinical Journal of Sport Medicine

Volumn 21, Issue 3, 2011, Pages 200-203

  Rogers, Ian R ^a,b   Hook, Ginger ^c   Stuempfle, Kristin J ^d   Hoffman, Martin D ^e,f   Hew Butler, Tamara ^g  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^c ARIZONA STATE UNIVERSITY   (United States)

^d GETTYSBURG COLLEGE   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g OAKLAND UNIVERSITY   (United States)

Author keywords

arginine vasopressin; endurance exercise; hyponatremia

Indexed keywords

ARGIPRESSIN; POTASSIUM; SODIUM CHLORIDE;

ARTICLE; BODY FAT; BODY MASS; CLINICAL ARTICLE; EXERCISE ASSOCIATED HYPONATREMIA; FEMALE; HUMAN; HYPONATREMIA; INTERVENTION STUDY; MALE; MARATHON RUNNER; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SODIUM BLOOD LEVEL; TOTAL BODY WATER;

EID: 85027945283     PISSN: 1050642X     EISSN: 15363724     Source Type: Journal    
DOI: 10.1097/JSM.0b013e31821a6450     Document Type: Article

References (13)

1. Carter R III. Exertional heat illness and hyponatremia: an epidemiological perspective. Curr Sports Med Rep. 2008;7:S20-S27.
2. Hew-Butler TD, Ayus JC, Kipps C, et al. Statement of the second international exercise-associated hyponatremia consensus development conference, New Zealand, 2007. Clin J Sport Med. 2008;18:111-121. (Pubitemid 351365715)
3. Hew-Butler T, Dugas JP, Noakes TD, et al. Changes in plasma vasopressin concentrations in cyclists participating in a 109 km cycle race. Br J Sports Med. 2010;44:594-597.
4. Lebus DK, Casazza GA, Hoffman MD, et al. Can changes in body mass and total body water predict hyponatremia after a 161-km running race? Clin J Sport Med. 2010;20:193-199.
5. Lamppa, R. 2009 Marathon and State of the Sport Reports RRIC Annual Marathon report. 2009. http://www.runningusa.org/node/16414. Accessed August 10, 2010.
6. Ayus JC, Varon J, Arieff AI. Hyponatremia, cerebral edema, and noncardiogenic pulmonary edema in marathon runners. Ann Intern Med. 2000;132:711-714. (Pubitemid 30244170)
7. Davis D, Videen JS, Marino A, et al. Exercise-associated hyponatremia in marathon runners; a two year experience. J Emerg Med. 2001;21:47-57. (Pubitemid 32496498)
8. Siegel AJ, d'Hemecourt P, Adner MM, et al. Exertional dysnatremia in collapsed marathon runners: a critical role for point-of-care testing to guide appropriate therapy. Am Clin Pathol. 2009;132:336-340.
9. Verbalis JG, McHale CM, Gardiner TW, et al. Oxytocin and vasopressin secretion in response to stimuli producing learned taste aversion in rats. Behav Neurosci. 1986;100:466-475. (Pubitemid 17169557)
10. Hew-Butler T, Sharwood K, Boulter J, et al. Dysnatremia predicts a delayed recovery in collapsed ultramarathon runners. Clin J Sport Med. 2007;17:289-296. (Pubitemid 47051790)
11. Hew-Butler T, Noakes TD, Siegel AJ. Practical management of exerciseassociated hyponatremic encephalopathy: the sodium paradox of nonosmotic vasopressin secretion. Clin J Sport Med. 2008;18:350-354.
12. Basnyat B, Sleggs J. Seizures and delirium in a trekker: the consequences of excessive water drinking? Wilderness Environ Med. 2000;11:69-70. (Pubitemid 30152415)
13. Hew-Butler T, Anley C, Schwartz P, et al. The treatment of symptomatic hyponatremia with hypertonic saline in an ironman triathlete. Clin J Sport Med. 2007;17:68-69. (Pubitemid 46279928)