Probing the coagulation pathway with aptamers identifies combinations that synergistically inhibit blood clot formation

Chemistry & biology

Volumn 21, Issue 8, 2014, Pages 935-944

  Bompiani, Kristin M ^a   Lohrmann, Jens L ^a   Pitoc, George A ^a   Frederiksen, James W ^a   Mackensen, George B ^a   Sullenger, Bruce A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APTAMER; BLOOD CLOTTING FACTOR; PROTHROMBIN;

ANTAGONISTS AND INHIBITORS; BLOOD CLOTTING; BLOOD CLOTTING TEST; DOSE RESPONSE; DRUG EFFECTS; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; METABOLISM; NORMAL HUMAN; STRUCTURE ACTIVITY RELATION;

APTAMERS, NUCLEOTIDE; BLOOD COAGULATION; BLOOD COAGULATION FACTORS; BLOOD COAGULATION TESTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; ENZYME ACTIVATION; HEALTHY VOLUNTEERS; HUMANS; PROTHROMBIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85027943821     PISSN: None     EISSN: 18791301     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.05.016     Document Type: Article

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