EGFR- and AKT-mediated reduction in PTEN expression contributes to tyrphostin resistance and is reversed by mTOR inhibition in endometrial cancer cells.

Molecular and cellular biochemistry

Volumn 361, Issue 1-2, 2012, Pages 19-29

  Li, Tian ^a   Yang, Yuebo ^b   Li, Xiaomao ^b   Xu, Chengfang ^b   Meng, Lirong ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA (3,5 DICHLOROBENZYLIDENE) 3 PYRIDYLACETONITRILE; ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MTOR PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PTEN PROTEIN, HUMAN; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; TYRPHOSTIN;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; DRUG RESISTANCE; ENDOMETRIUM TUMOR; FEMALE; GENE SILENCING; GENETICS; HUMAN; IC 50; METABOLISM; PHOSPHORYLATION; RNA INTERFERENCE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENDOMETRIAL NEOPLASMS; FEMALE; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT FUSION PROTEINS; RNA INTERFERENCE; SIROLIMUS; TOR SERINE-THREONINE KINASES; TYRPHOSTINS;

EID: 85027933817     PISSN: None     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-1082-0     Document Type: Article

References (0)