Expression of recombinant anti-breast cancer immunotherapeutic monoclonal antibody in baculovirus-insect cell system

Entomological Research

Volumn 44, Issue 5, 2014, Pages 207-214

  Lee, Jeong Hwan ^a,b   Hwang, Kyung A ^c   Park, SungSu ^d   Choo, Young Kug ^e   Ko, Kisung ^a  

^a Chung Ang University   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

^c National Institute of Animal Science   (South Korea)

^d Sungkyunkwan University   (South Korea)

^e Wonkwang University   (South Korea)

Author keywords

Baculovirus expression system; Breast cancer; Insect derived antibody; mAb BR55; Therapeutic antibody

Indexed keywords

EID: 85027933195     PISSN: 17382297     EISSN: 17485967     Source Type: Journal    
DOI: 10.1111/1748-5967.12067     Document Type: Article

References (27)

1. Ahn MH, Song M, Oh EY et al. (2008) Production of therapeutic proteins with baculovirus expression system in insect cell. Entomological Research 38: 71-78.
2. Brekke OH, Sandlie I. (2003) Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nature Reviews Drug Discovery 2: 52-62.
3. Brodzik R, Glogowska M, Bandurska K et al. (2006) Plantderived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells. Proceedings of the National Academy of Sciences of the United States of America 103: 8804-8809.
4. Ellgaard L, Molinari M, Helenius A. (1999) Setting the standards: quality control in the secretory pathway. Science 286: 1882- 1888.
5. Geisler C, Aumiller JJ, Jarvis DL. (2008) A fused lobes gene encodes the processing α-N-Acetylglucosaminidase in Sf9 cells. Journal of Biological Chemistry 17: 11 330-11 339.
6. Grados A, Ebbo M, Schleinitz N et al. (2013) Serum immunoglobulin free light chain assessment in IgG4-related disease. International Journal of Rheumatology 426 759: 1-6.
7. Gröner A. (1986) Specificity and safety of baculoviruses. In: Granados RR, Federici BA (eds) The Biology of Baculoviruses: Biological Properties and Molecular Biology, pp 177-202. CRC Press, Boca Raton, FL.
8. Hervas-stubbs S, Rueda P, Lopez L, Leclerc C. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. The Journal of Immunology 178: 2361-2369.
9. Hu Y. (2005) Baculovirus as a highly efficient expression vector in insect and mammalian cells. Acta Pharmacologica Sinica 26: 405-416.
10. Izrailit J, Reedijk M. (2012) Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications. Cancer Letters 317: 115-126.
11. Jarvis DL. (2003) Developing baculovirus-insect cell expression systems for humanized recombinant glycoprotein production. Virology 310: 1-7.
12. Kim KS, Kim KH, Choi SE, Yoon JW, Kang Y. (1999) Soluble expression in Escherichia coli of Murine endogenous retroviral transmembrane envelope protein having immunosuppressive activity. Protein Expression and Purification 16: 19-26.
13. Kitts PA. (1996) Construction of baculovirus recombinants. Cytotechnology 20: 111-123.
14. Ko K, Tekoah Y, Rudd PM et al. (2003) Function and glycosylation of plant-derived antiviral monoclonal antibody. Proceedings of the National Academy of Sciences of the United States of America 100: 8013-8018.
15. Luckow VA, Lee SC, Barry GF, Olins PO. (1993) Efficient generation of infectious recombinant baculoviruses by site-specific transposon-mediated insertion of foreign genes into a baculovirus genome propagated in Escherichia coli. Journal of Virology 67: 4566-4579.
16. Munro S, Pelham HR. (1987) A C-terminal signal prevents secretion of luminal ER proteins. Cell 48: 899-907.
17. Nguyen NP, Almeida FS, Chi A et al. (2010) Molecular biology of breast cancer stem cells: potential clinical applications. Cancer Treatment Reviews 36: 485-491.
18. O'Reilly DR, Miller LK, Luckow VA. (1994) Baculovirus Expression Vectors: A Laboratory Manual. W.H. Freeman and Company, New York.
19. Park DY, Lee JH, So YK et al. (2011) Optimization of expression conditions for production of anti-colorectal cancer monoclonal antibody CO17-1A in baculovirus-insect cell system. Hybridoma 30: 419-426.
20. Pelham HR. (1988) Evidence that luminal ER proteins are sorted from secreted proteins in a post-ER compartment. EMBO Journal 7: 913-918.
21. Pelham HR. (1990) The retention signal for soluble proteins of the endoplasmic reticulum. Trends in Biochemical Science 15: 483-486.
22. Seo H, Park DY, Kim M et al. (2009) Establishment of Baculovirus infected insect cell line expressing procine salivary lipocalin (SAL1) protein. Reproductive and Developmental Biology 33: 71-76.
23. So YK, Lee KJ, Kim DS et al. (2013) Glycomodification and characterization of anti-colorectal cancer immunotherapeutic monoclonal antibody in transgenic tobacco. Plant Cell, Tissue and Organ Culture 113: 41-49.
24. Song MR, Park DY, Kim YK et al. (2010) Characterization of N-glycan structures and bio function of anti-colorectal cancer monoclonal antibody CO17-1A produced in baculovirus insect cell expression system. Journal of Bioscience and Bioengineering 110: 135-140.
25. Staib L, Birebent B, Somasundaram R et al. (2001) Immunogenicity of recombinant GA733-2E antigen (CO17-1A, EGP, KS1-4, KSA, Ep-CAM) in gastro-intestinal carcinoma patients. International Journal of Cancer 92: 79-87.
26. Vaughn JL, Goodwin RH, Tompkins GJ, McCawley P. (1977) The establishment of two cell lines from the insect Spodoptera frugiperda (Lepidoptera: Noctuidae). In Vitro 13: 213- 217.
27. Xing Z, Kenty BM, Li ZJ, Lee SS. (2009) Scale-up analysis for a CHO cell culture process in large-scale bioreactors. Biotechnology and Bioengineering 103: 733-746.