Effects of a single-dose hypertonic saline hydroxyethyl starch on cerebral blood flow, long-term outcome, neurogenesis, and neuronal survival after cardiac arrest and cardiopulmonary resuscitation in rats

Critical Care Medicine

Volumn 40, Issue 7, 2012, Pages 2149-2156

  Noppens, Rüdiger R ^a   Kelm, Robert F ^a   Lindemann, Raphaele ^a   Engelhard, Kristin ^a   Werner, Christian ^a   Kempski, Oliver ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Asphyxia; cardiac arrest; cardiopulmonary resuscitation; cerebral blood flow; hypertonic saline; neurogenesis; neuronal survival

Indexed keywords

HETASTARCH;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; HEART ARREST; HISTOPATHOLOGY; MALE; MEAN ARTERIAL PRESSURE; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; RESUSCITATION; TREATMENT OUTCOME;

EID: 85027931953     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31824e6750     Document Type: Article

References (36)

1. Polentini MS, Pirrallo RG, McGill W: The changing incidence of ventricular fibrillation in Milwaukee, Wisconsin (1992-2002). Prehosp Emerg Care 2006; 10:52-60 (Pubitemid 43154904)
2. Sans S, Kesteloot H, Kromhout D: The burden of cardiovascular diseases mortality in Europe. Task Force of the European Society of Cardiology on Cardiovascular Mortality and Morbidity Statistics in Europe. Eur Heart J 1997; 18:1231-1248
3. Deakin CD, Morrison LJ, Morley PT, et al; Advanced Life Support Chapter Collaborators: Part 8: Advanced life support: 2010 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science with Treatment Recommendations. Resuscitation 2010; 81(Suppl 1):e93-e174
4. Böttiger BW, Krumnikl JJ, Gass P, et al: The cerebral 'no-reflow' phenomenon after cardiac arrest in rats-influence of low-flow reperfusion. Resuscitation 1997; 34:79-87 (Pubitemid 27077469)
5. Fischer M, Hossmann KA: No-reflow after cardiac arrest. Intensive Care Med 1995; 21:132-141
6. Hauck EF, Apostel S, Hoffmann JF, et al: Capillary flow and diameter changes during reperfusion after global cerebral ischemia studied by intravital video microscopy. J Cereb Blood Flow Metab 2004; 24:383-391 (Pubitemid 38455441)
7. Uhl E, Beck J, Stummer W, et al: Leukocyte-endothelium interactions in pial venules during the early and late reperfusion period after global cerebral ischemia in gerbils. J Cereb Blood Flow Metab 2000; 20:979-987 (Pubitemid 30413681)
8. de Felippe J Jr, Timoner J, Velasco IT, et al: Treatment of refractory hypovolaemic shock by 7.5% sodium chloride injections. Lancet 1980; 2:1002-1004 (Pubitemid 10025072)
9. Velasco IT, Pontieri V, Rocha E, Silva M Jr, et al: Hyperosmotic NaCl and severe hemorrhagic shock. Am J Physiol 1980; 239:H664-H673 (Pubitemid 11241496)
10. Fischer M, Dahmen A, Standop J, et al: Effects of hypertonic saline on myocardial blood flow in a porcine model of prolonged cardiac arrest. Resuscitation 2002; 54:269-280 (Pubitemid 35245480)
11. Maningas PA: Resuscitation with 7.5% NaCl in 6% dextran-70 during hemorrhagic shock in swine: Effects on organ blood flow. Crit Care Med 1987; 15:1121-1126
12. Heimann A, Takeshima T, Alessandri B, et al: Effects of hypertonic/hyperoncotic treatment after rat cortical vein occlusion. Crit Care Med 2003; 31:2495-2501 (Pubitemid 37281735)
13. Jussen D, Papaioannou C, Heimann A, et al: Effects of hypertonic/hyperoncotic treatment and surgical evacuation after acute subdural hematoma in rats. Crit Care Med 2008; 36:543-549 (Pubitemid 351158631)
14. Timmons SD: Current trends in neurotrauma care. Crit Care Med 2010; 38(Suppl 9):S431-S444
15. Noppens RR, Christ M, Brambrink AM, et al: An early bolus of hypertonic saline hydroxyethyl starch improves long-term outcome after global cerebral ischemia. Crit Care Med 2006; 34:2194-2200 (Pubitemid 44305625)
16. Kelm RF, Wagenführer J, Schmidtmann I, et al: Transpulmonary cardiac output measurement in a rat model of cardiac arrest and CPR: Impact of vascular access. Resuscitation 2010; 81:248-254
17. Hickey RW, Ferimer H, Alexander HL, et al: Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats. Crit Care Med 2000; 28:3511-3516
18. Hendrickx HH, Safar P, Miller A: Delayed recovery of behavior after anesthesia in rats. Resuscitation 1984; 12:213-221 (Pubitemid 15202316)
19. Katz L, Ebmeyer U, Safar P, et al: Outcome model of asphyxial cardiac arrest in rats. J Cereb Blood Flow Metab 1995; 15:1032-1039
20. Lasarzik I, Winkelheide U, Stallmann S, et al: Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia. Anesthesiology 2009; 110:529-537
21. Engelhard K, Winkelheide U, Werner C, et al: Sevoflurane affects neurogenesis after forebrain ischemia in rats. Anesth Analg 2007; 104:898-903 (Pubitemid 46548318)
22. Soehle M, Heimann A, Kempski O: Postischemic application of lipid peroxidation inhibitor U-101033E reduces neuronal damage after global cerebral ischemia in rats. Stroke 1998; 29:1240-1246; discussion 1246
23. Sterz F, Leonov Y, Safar P, et al: Multifocal cerebral blood flow by Xe-CT and global cerebral metabolism after prolonged cardiac arrest in dogs. Reperfusion with open-chest CPR or cardiopulmonary bypass. Resuscitation 1992; 24:27-47
24. Schneider A, Böttiger BW, Popp E: Cerebral resuscitation after cardiocirculatory arrest. Anesth Analg 2009; 108:971-979
25. Fischer M, Hossmann KA: Volume expansion during cardiopulmonary resuscitation reduces cerebral no-reflow. Resuscitation 1996; 32:227-240 (Pubitemid 26354169)
26. Mazzoni MC, Borgström P, Warnke KC, et al: Mechanisms and implications of capillary endothelial swelling and luminal narrowing in low-flow ischemias. Int J Microcirc Clin Exp 1995; 15:265-270
27. Pascual JL, Khwaja KA, Chaudhury P, et al: Hypertonic saline and the microcirculation. J Trauma 2003; 54(Suppl 5):S133-S140 (Pubitemid 36758863)
28. Breil M, Krep H, Sinn D, et al: Hypertonic saline improves myocardial blood flow during CPR, but is not enhanced further by the addition of hydroxy ethyl starch. Resuscitation 2003; 56:307-317 (Pubitemid 36288518)
29. Nozari A, Rubertsson S, Gedeborg R, et al: Maximisation of cerebral blood flow during experimental cardiopulmonary resuscitation does not ameliorate post-resuscitation hypoperfusion. Resuscitation 1999; 40:27-35 (Pubitemid 29152079)
30. Miclescu A, Basu S, Wiklund L: Cardio-cerebral and metabolic effects of methylene blue in hypertonic sodium lactate during experimental cardiopulmonary resuscitation. Resuscitation 2007; 75:88-97 (Pubitemid 47331997)
31. Breil M, Krep H, Heister U, et al: Randomised study of hypertonic saline infusion during resuscitation from out-of-hospital cardiac arrest. Resuscitation 2012; 83:347-352
32. Chen CH, Xue R, Zhang J, et al: Effect of osmotherapy with hypertonic saline on regional cerebral edema following experimental stroke: A study utilizing magnetic resonance imaging. Neurocrit Care 2007; 7:92-100 (Pubitemid 350242687)
33. Negovsky VA: Postresuscitation disease. Crit Care Med 1988; 16:942-946
34. Keilhoff G, John R, Langnaese K, et al: Triggered by asphyxia neurogenesis seems not to be an endogenous repair mechanism, gliogenesis more like it. Neuroscience 2010; 171:869-884
35. Bhardwaj A, Harukuni I, Murphy SJ, et al: Hypertonic saline worsens infarct volume after transient focal ischemia in rats. Stroke 2000; 31:1694-1701 (Pubitemid 30437525)
36. Ayus JC, Krothapalli RK, Armstrong DL: Rapid correction of severe hyponatremia in the rat: Histopathological changes in the brain. Am J Physiol 1985; 248(5 Pt 2):F711-F719 (Pubitemid 15026017)