Association between plasma leptin and blood pressure in two population-based samples of children and adolescents

Journal of Hypertension

Volumn 29, Issue 6, 2011, Pages 1093-1100

  Grøntved, Anders ^a,b   Steene Johannessen, Jostein ^c   Kynde, Iben ^d   Franks, Paul W ^b,e   Helge, Jørn Wulf ^f   Froberg, Karsten ^a   Anderssen, Sigmund A ^c   Andersen, Lars Bo ^a,g  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c WESTERN NORWAY UNIVERSITY OF APPLIED SCIENCES   (Norway)

^d UNIVERSITY COLLEGE COPENHAGEN   (Denmark)

^e LUND UNIVERSITY   (Sweden)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g NORWEGIAN SCHOOL OF SPORT SCIENCES   (Norway)

Author keywords

adiposity; blood pressure; children; leptin

Indexed keywords

CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LEPTIN; TRIACYLGLYCEROL;

ADOLESCENT; ANTHROPOMETRY; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR RISK; CHILD; CHOLESTEROL BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SYSTOLIC BLOOD PRESSURE;

EID: 85027930595     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328346d787     Document Type: Article

References (42)

1. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. Sympathetic and cardiorenal actions of leptin. Hypertension 1997; 30:619-623. (Pubitemid 27444241)
2. Seeley RJ, Yagaloff KA, Fisher SL, Burn P, Thiele TE, van Dijk G, et al. Melanocortin receptors in leptin effects. Nature 1997; 390:349.
3. Farooqi IS, O'Rahilly S. Leptin: a pivotal regulator of human energy homeostasis. Am J Clin Nutr 2009; 89:980S-9984.
4. Carlyle M, Jones OB, Kuo JJ, Hall JE. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension 2002; 39:496-501. (Pubitemid 34165172)
5. Lembo G, Vecchione C, Fratta L, Marino G, Trimarco V, d'Amati G, et al. Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes 2000; 49:293-297. (Pubitemid 30071008)
6. Asferg C, Mogelvang R, Flyvbjerg A, Frystyk J, Jensen JS, Marott JL, et al. Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study. Am J Hypertens 2009; 23:327-333.
7. Barba G, Russo O, Siani A, Iacone R, Farinaro E, Gerardi MC, et al. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obesity 2003; 11:160-166. (Pubitemid 41137552)
8. Galletti F, D'Elia L, Barba G, Siani A, Cappuccio FP, Farinaro E, et al. Highcirculating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an eightyear follow-up study. J Clin Endocrinol Metab 2008; 93:3922-3926.
9. Hu FB, Chen C, Wang B, Stampfer MJ, Xu X. Leptin concentrations in relation to overall adiposity, fat distribution, and blood pressure in a rural Chinese population. Int J Obes Relat Metab Disord 2001; 25:121-125. (Pubitemid 32142393)
10. Kramer CK, Von Mü hlen D, Barrett-Connor E. Does leptin predict incident hypertension in older adults? Clin Endocrinol 2010; 73:201-205.
11. Ma D, Feitosa MF, Wilk JB, Laramie JM, Yu K, Leiendecker-Foster C, et al. Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study. Hypertension 2009; 53:473-479.
12. Shankar A, Xiao J. Positive relationship between plasma leptin level and hypertension. Hypertension 2010; 56:623-628.
13. Franks PW, Brage S, Luan J, Ekelund U, Rahman M, Farooqi IS, et al. Leptin predicts a worsening of the features of the metabolic syndrome independently of obesity. Obesity 2005; 13:1476-1484.
14. Montague CT. Congenital leptin deficiency is associated with severe earlyonset obesity in humans. Nature 1997; 387:903-908. (Pubitemid 27289591)
15. Clement K. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392:398-401. (Pubitemid 28168737)
16. Scarpace PJ, Zhang Y. Leptin resistance: a prediposing factor for dietinduced obesity. Am J Physiol Regul Integrat Comparat Physiol 2009; 296:R493-R500.
17. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, et al. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334:292-295. (Pubitemid 26033933)
18. Hamilton BS, Paglia D, Kwan AYM, Deitel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1995; 1:953-956.
19. Heymsfield SB, Greenberg AS, Fujioka K, Dixon RM, Kushner R, Hunt T, et al. Recombinant leptin for weight loss in obese and lean adults. JAMA 1999; 282:1568-1575.
20. Chu NF, Wang DJ, Shieh SM. Obesity, leptin and blood pressure among children in Taiwan: The Taipei Children's Heart Study. Am J Hypertens 2001; 14:135-140.
21. Lambert M, O'Loughlin J, Delvin EE, Levy E, Chiolero A, Paradis G. Association between insulin, leptin, adiponectin and blood pressure in youth. J Hypertens 2009; 27:1025-1032.
22. Riddoch C, Edwards D, Page A, Froberg K, Anderssen SA, Wedderkopp N, et al. The European Youth Heart Study: cardiovascular disease risk factors in children: rationale, aims, design and validation of methods. J Physical Activity Health 2005; 2:115-129.
23. Steene-Johannessen J, Kolle E, Anderssen SA, Andersen LB. Cardiovascular disease risk factors in a population-based sample of Norwegian children and adolescents. Scand J Clin Laborat Investig 2009; 69:380-386.
24. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000; 320:1240-1243. (Pubitemid 30240471)
25. Tanner JM. Growth at adolescence. Oxford: Blackwell; 1962.
26. Kynde I, Heitmann BL, Bygbjerg IC, Andersen LB, Helge JW. Hypoadiponectinemia in overweight children contributes to a negative metabolic risk profile 6 years later. Metabolism 2009; 58:1817-1824.
27. Kynde I, Heitmann BL, Bygbjerg IC, Andersen LB, Helge JrW. Childhood hypo-adiponectinaemia but not hyper-leptinaemia is associated with insulin insensitivity 6 years later. Pediatr Diabet 2010; 11:195-202.
28. Steene-Johannessen J, Kolle E, Reseland JE, Anderssen SA, Andersen LB. Waist circumference is related to low-grade inflammation in youth. Int J Pediatric Obesity 2010; 5:313-319.
29. Park MK, Menard SM. Accuracy of blood pressure measurement by the Dinamap Monitor in infants and children. Pediatrics 1987; 79:907-914. (Pubitemid 17079004)
30. Falkner B, Daniels SR. Summary of the Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Hypertension 2004; 44:387-388. (Pubitemid 39281480)
31. Preacher KJ, Hayes AF. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods Instrum Comput 2004; 36:717-731. (Pubitemid 40251423)
32. Sobel ME. Asymptotic confidence intervals for indirect effects in structural equation models. Sociological methodology. San Francisco: Jossey-Bass; 1982.
33. Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: The Bogalusa Heart Study. Pediatrics 2001; 108:712-718. (Pubitemid 32786603)
34. Sinaiko AR, Donahue RP, Jacobs DR Jr, Prineas RJ. Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults: The Minneapolis Children's Blood Pressure Study. Circulation 1999; 99:1471-1476. (Pubitemid 29140914)
35. Ghodsi M, Fakhrzadeh H, Moayyeri A, Hamidi A, Ebrahimpour P, Larijani B. Serum leptin levels and hypertension in Iranian obese children. Endocrinologist 2007; 17:258-261. (Pubitemid 47508889)
36. Nishina M, Kikuchi T, Yamazaki H, Kameda K, Hiura M, Uchiyama M. Relationship among systolic blood pressure, serum insulin and leptin, and visceral fat accumulation in obese children. Hypertens Res 2003; 26:281-288. (Pubitemid 36575781)
37. Valle M, Martos R, Gascon F, Canete R, Zafra MA, Morales R. Low-grade systemic inflammation, hypoadiponectinemia and a high concentration of leptin are present in very young obese children, and correlate with metabolic syndrome. Diabetes Metab 2005; 31:55-62. (Pubitemid 40327593)
38. Clayton PE, Gill MS, Hall CM, Tillmann V, Whatmore AJ, Price DA. Serum leptin through childhood and adolescence. Clin Endocrinol 1997; 46:727-733. (Pubitemid 27304458)
39. Lindsay RS, Hanson RL, Roumain J, Ravussin E, Knowler WC, Tataranni PA. Body mass index as a measure of adiposity in children and adolescents: relationship to adiposity by dual energy X-ray absorptiometry and to cardiovascular risk factors. J Clin Endocrinol Metab 2001; 86:4061-4067. (Pubitemid 32848513)
40. Pietrobelli A, Faith MS, Allison DB, Gallagher D, Chiumello G, Heymsfield SB. Body mass index as a measure of adiposity among children and adolescents: a validation study. J Pediatrics 1998; 132:204-210. (Pubitemid 28125168)
41. Mei Z, Grummer-Strawn LM, Wang J, Thornton JC, Freedman DS, Pierson RN Jr, et al. Do skinfold measurements provide additional information to body mass index in the assessment of body fatness among children and adolescents? Pediatrics 2007; 119:e1306-e1313. (Pubitemid 46871249)
42. Reilly JJ, Dorosty AR, Ghomizadeh NM, Sherriff A, Wells JC, Ness AR. Comparison of waist circumference percentiles versus body mass index percentiles for diagnosis of obesity in a large cohort of children. Int J Pediatric Obesity 2010; 5:151-156.