Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine

Journal of Headache and Pain

Volumn 12, Issue 2, 2011, Pages 239-243

  Uzar, Ertugrul ^a   Evliyaoglu, Osman ^b   Toprak, Gülten ^b   Acar, Abdullah ^a   Yucel, Yavuz ^a   Calisir, Tugba ^a   Cevik, Mehmet Ugur ^a   Tasdemir, Nebahat ^a  

^a DICLE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b DICLE UNIVERSITY   (Turkey)

Author keywords

Asymmetric dimethylargininenitric oxide; Endothelial dysfunction; Migraine; Oxidative stress

Indexed keywords

N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE;

ADULT; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE WITH AURA; MIGRAINE WITHOUT AURA; OXIDATIVE STRESS; PLASMA; PRIORITY JOURNAL;

EID: 85027922830     PISSN: 11292369     EISSN: 11292377     Source Type: Journal    
DOI: 10.1007/s10194-011-0323-7     Document Type: Article

References (32)

1. Silva FA, Rueda-Clausen CF, Silva SY, Zarruk JG, Guzmán JC, Morillo CA, Vesga B, Pradilla G, Flórez M, López-Jaramillo P (2007) Endothelial function in patients with migraine during the interictal period. Headache 47:45-51 (Pubitemid 46096056)
2. Sarchielli P, Alberti A, Vaianella L, Pierguidi L, Floridi A, Mazzotta G, Floridi A, Gallai V (2004) Chemokine levels in the jugular venous blood of migraine without aura patients during attacks. Headache 44:961-968 (Pubitemid 39532337)
3. Toda N, Ayajiki K, Okamura T (2009) Cerebral blood flow regulation by nitric oxide in neurological disorders. Can J Physiol Pharmacol 87:581-594
4. Ciancarelli I, Tozzi-Ciancarelli MG, Di Massimo C, Marini C, Carolei A (2003) Urinary nitric oxide metabolites and lipid peroxidation by-products in migraine. Cephalalgia 23:39-42 (Pubitemid 36356803)
5. Yilmaz G, Sürer H, Inan LE, Coskun O, Yücel D (2007) Increased nitrosative and oxidative stress in platelets of migraine patients. Tohoku J Exp Med 211:23-30 (Pubitemid 46062216)
6. Tain YL, Kao YH, Hsieh CS, Chen CC, Sheen JM, Lin IC, Huang LT (2010) Melatonin blocks oxidative stress-induced increased asymmetric dimethylarginine. Free Radic Biol Med (in press)
7. Guldiken B, Demir M, Guldiken S, Turgut N, Ozkan H, Kabayel L, Tugrul A (2009) Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period. J Clin Neurosci 16:672-674
8. Gruber HJ, Bernecker C, Lechner A, Weiss S, Wallner-Blazek M, Meinitzer A, Höbarth G, Renner W, Fauler G, Horejsi R, Fazekas F, Truschnig-Wilders M (2009) Increased nitric oxide stress is associated with migraine. Cephalalgia 30:486-492
9. Lima MM, Padula NA, Santos LC, Oliveira LD, Agapejev S, Padovani C (2005) Critical analysis of the international classification of headache disorders diagnostic criteria (ICHD I-1988) and (ICHD II-2004), for migraine in children and adolescents. Cephalalgia 25:1042-1047 (Pubitemid 41532109)
10. Cortas NK, Wakid NW (1990) Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 36:1440-1443
11. Schulze F, Wesemann R, Schwedhelm E, Sydow K, Albsmeier J, Cooke JP, Böger RH (2004) Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay. Clin Chem Lab Med 42:1377-1383 (Pubitemid 40057825)
12. Ciancarelli I, Tozzi-Ciancarelli MG, Di Massimo C, Olivieri L, Carolei A (2005) Preventive non-pharmacological treatment and nitric oxide in chronic migraine. J Headache Pain 6:341-342 (Pubitemid 41349345)
13. Olesen J (2008) The role of nitric oxide (NO) in migraine, tension- type headache and cluster headache. Pharmacol Ther 120:157-171
14. Napoli R, Guardasole V, Zarra E, Matarazzo M, D'Anna C, Saccà F, Affuso F, Cittadini A, Carrieri PB, Saccà L (2009) Vascular smooth muscle cell dysfunction in patients with migraine. Neurology 72:2111-2114
15. Sarchielli P, Alberti A, Codini M, Floridi A, Gallai V (2000) Nitric oxide metabolites, prostaglandins and trigeminal vasoactive peptides in internal jugular vein blood during spontaneous migraine attacks. Cephalalgia 20:907-918 (Pubitemid 32336718)
16. Gruber HJ, Bernecker C, Pailer S, Fauler G, Horejsi R, Möller R, Lechner A, Fazekas F, Truschnig-Wilders M (2009) Hyperinsulinaemia in migraineurs is associated with nitric oxide stress. Cephalalgia 30:593-598
17. Förstermann U (2008) Oxidative stress in vascular disease: causes, defense mechanisms and potential therapies. Nat Clin Pract Cardiovasc Med. 5:338-349
18. Taffi R, Vignini A, Lanciotti C, Luconi R, Nanetti L, Mazzanti L, Provinciali L, Silvestrini M, Bartolini M (2005) Platelet membrane fluidity and peroxynitrite levels in migraine patients during headache-free periods. Cephalalgia 25:353-358 (Pubitemid 40559417)
19. Fidan I, Yüksel S, Ymir T, Irkeç C, Aksakal FN (2006) The importance of cytokines, chemokines and nitric oxide in pathophysiology of migraine. J Neuroimmunol 171:184-188 (Pubitemid 41832289)
20. Shimomura T, Murakami F, Kotani K, Ikawa S, Kono S (1999) Platelet nitric oxide metabolites in migraine. Cephalalgia 19:218-222 (Pubitemid 29268494)
21. Shukla R, Barthwal MK, Srivastava N, Nag D, Seth PK, Srimal RC, Dikshit M (2001) Blood nitrite levels in patients with migraine during headache-free period. Headache. 41:475-481 (Pubitemid 32466395)
22. Van der Kuy PH, Merkus FW, Lohman JJ, ter Berg JW, Hooymans PM (2002) Hydroxocobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study. Cephalalgia 22:513-519 (Pubitemid 36609344)
23. Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease: a population-based study. Neurology 74:628-635
24. Kurth T (2010) The association of migraine with ischemic stroke. Curr Neurol Neurosci Rep 10:133-139
25. Siekmeier R, Grammer T, März W (2008) Roles of oxidants, nitric oxide, and asymmetric dimethylarginine in endothelial function. J Cardiovasc Pharmacol Ther 13:279-297
26. De Gennaro Colonna V, Bianchi M, Pascale V, Ferrario P, Morelli F, Pascale W, Tomasoni L, Turiel M (2009) Asymmetric dimethylarginine (ADMA): an endogenous inhibitor of nitric oxide synthase and a novel cardiovascular risk molecule. Med Sci Monit 15:91-101
27. Dayoub H, Rodionov RN, Lynch C, Cooke JP, Arning E, Bottiglieri T, Lentz SR, Faraci FM (2008) Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke 39:180-184
28. Hamed SA, Hamed EA, Ezz Eldin AM, Mahmoud NM (2010) Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis. J Stroke Cerebrovasc Dis 19:92-103
29. Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA (2009) Migraine and biomarkers of endothelial activation in young women. Stroke 40:2977-2982
30. Borroni B, Rao R, Liberini P, Venturelli E, Cossandi M, Archetti S, Caimi L, Padovani A (2006) Endothelial nitric oxide synthase (Glu298Asp) polymorphism is an independent risk factor for migraine with aura. Headache 46:1575-1579 (Pubitemid 44722196)
31. Stovner LJ, Tronvik E, Hagen K (2009) New drugs for migraine. J Headache Pain 10:395-406
32. Farinelli I, De Filippis S, Coloprisco G, Missori S, Martelletti P (2009) Future drugs for migraine. Intern Emerg Med 4:367-373