The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: a retrospective analysis of the FEATHER study

Thrombosis research

Volumn 134, Issue 3, 2014, Pages 552-557

  Jakubowski, Joseph A ^a   Angiolillo, Dominick J ^a   Zhou, Chunmei ^a   Small, David S ^a   Moser, Brian A ^a   Ten Berg, Jurrien M ^a   Brown, Patricia B ^a   James, Stefan ^a   Winters, Kenneth J ^a   Erlinge, David ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Body mass index; Clopidogrel; Pharmacodynamics; Pharmacokinetics; Prasugrel

Indexed keywords

ACTIN BINDING PROTEIN; ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; CELL ADHESION MOLECULE; CLOPIDOGREL; P2RY12 PROTEIN, HUMAN; PHOSPHOPROTEIN; PRASUGREL; PURINERGIC P2Y RECEPTOR ANTAGONIST; PURINERGIC P2Y12 RECEPTOR; TICLOPIDINE; VASODILATOR-STIMULATED PHOSPHOPROTEIN;

ADULT; AGED; ANALOGS AND DERIVATIVES; BLOOD; BLOOD CLOTTING PARAMETERS; BODY MASS; BODY SIZE; BODY SURFACE; BODY WEIGHT; COMPARATIVE STUDY; CORONARY ARTERY DISEASE; DOSE CALCULATION; DRUG EFFECTS; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; THROMBOCYTE; THROMBOCYTE AGGREGATION; TREATMENT OUTCOME;

ADULT; AGED; BIOMARKERS; BLOOD PLATELETS; BODY MASS INDEX; BODY SIZE; BODY SURFACE AREA; BODY WEIGHT; CELL ADHESION MOLECULES; CORONARY ARTERY DISEASE; DRUG DOSAGE CALCULATIONS; FEMALE; HUMANS; MALE; MICROFILAMENT PROTEINS; MIDDLE AGED; PHOSPHOPROTEINS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET FUNCTION TESTS; PRASUGREL HYDROCHLORIDE; PURINERGIC P2Y RECEPTOR ANTAGONISTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECEPTORS, PURINERGIC P2Y12; RETROSPECTIVE STUDIES; TICLOPIDINE; TREATMENT OUTCOME;

EID: 85027922782     PISSN: None     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2014.05.019     Document Type: Article

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