Flow-mediated dilation of the radial artery is offset by flow-induced reduction in transmural pressure

Hypertension

Volumn 57, Issue 6, 2011, Pages 1145-1150

  Jiang, Benyu ^a   Seddon, Mike ^a   Fok, Henry ^a   Donald, Ann ^a   Chowienczyk, Phil ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

blood flow velocity; blood pressure; nitric oxide; vascular endothelium dependent relaxation; vasodilation

Indexed keywords

CHOLESTEROL; N(G) METHYLARGININE; NITRIC OXIDE SYNTHASE INHIBITOR;

ADULT; ARTERIAL PRESSURE; ARTERY DIAMETER; ARTICLE; BLOOD FLOW; BLOOD FLOW VELOCITY; BODY MASS; BRACHIAL ARTERY; CHOLESTEROL BLOOD LEVEL; CLINICAL ASSESSMENT; ENDOTHELIUM CELL; HUMAN; HYPEREMIA; INFUSION; MODULATION; NORMAL HUMAN; PRIORITY JOURNAL; RADIAL ARTERY; SHEAR STRESS; TRANSMURAL PRESSURE; VASODILATATION;

EID: 85027919545     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.163113     Document Type: Article

References (23)

1. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet. 1992;340:1111-1115.
2. Brunner H, Cockcroft JR, Deanfield J, Donald A, Ferrannini E, Halcox J, Kiowski W, Luscher TF, Mancia G, Natali A, Oliver JJ, Pessina AC, Rizzoni D, Rossi GP, Salvetti A, Spieker LE, Taddei S, Webb DJ. Endothelial function and dysfunction: part II-ssociation with cardiovascular risk factors and diseases: a statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005;23:233-246. (Pubitemid 40279622)
3. Deanfield JE, Halcox JP, Rabelink TJ. Endothelial function and dysfunction: testing and clinical relevance. Circulation. 2007;115: 1285-1295. (Pubitemid 46594773)
4. Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996;79:984-991. (Pubitemid 26359238)
5. Pyke KE, Tschakovsky ME. The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol. 2005;568:357-369. (Pubitemid 41555444)
6. Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature. 1987; 327:524-526. (Pubitemid 17085822)
7. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, Thuillez C, Lüscher TF. Nitric oxide is responsible for flow-dependent dilation of human peripheral conduit arteries in vivo. Circulation. 1995;88: 2511-2516.
8. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol. 2002;39:257-265. (Pubitemid 34084631)
9. Black MA, Cable NT, Thijssen DHJ, Green DJ. Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension. 2008;51:203-210. (Pubitemid 351159929)
10. Pyke KE, Dwyer EM, Tschakovsky ME. Impact of controlling shear rate on flow-mediated dilation responses in the brachial artery of humans. J Appl Physiol. 2004;97:499-508. (Pubitemid 38963116)
11. Kuchan MJ, Frangos JA. Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells. Am J Physiol. 1993;264:H150-H156. (Pubitemid 23059138)
12. Harrison VJ, Ziegler T, Bouzourene K, Suciu A, Silacci P, Hayoz D. Endothelin-1 and endothelin-converting enzyme-1 gene regulation byshear stress and flow-induced pressure. J Cardiovasc Pharmacol. 1998; 31(suppl 1):S38-S41. (Pubitemid 128709863)
13. Cardillo C, Campia U, Kilcoyne CM, Bryant MB, Panza JA. Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension. Circulation. 2002;105: 452-456. (Pubitemid 34141701)
14. Pauca AL, Wallenhaupt SL, Kon ND, Tucker WY. Does radial artery pressure accurately reflect aortic pressure? Chest. 1992;102:1193-1198.
15. Johnson PC. The myogenic response. News Physiol Sci. 1991;6:41-42.
16. Hughes JM, Bund SJ. Arterial myogenic properties of the spontaneously hypertensive rat. Exp Physiol. 2002;87:527-534. (Pubitemid 35012225)
17. Pyke KE, Tschakovsky ME. Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol. 2007;102:1510-1519. (Pubitemid 46571047)
18. Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, Newcomer SC, Laughlin MH, Cable NT, Green DJ. Impact of shear rate modulation on vascular function in humans. Hypertension. 2009;54: 278-285.
19. Thijssen DH, Bullens LM, van Bemmel MM, Dawson EA, Hopkins N, Tinken TM, Black MA, Hopman MT, Cable NT, Green DJ. Does arterial shear explain the magnitude of flow-mediated dilation? A comparison between young and older humans. Am J Physiol Heart Circ Physiol. 2009;296:H57-H64.
20. Tschakovsky ME, Pyke KE. Counterpoint: flow-mediated dilation does not reflect nitric oxide-mediated endothelial function. J Appl Physiol. 2005;99:1235-1237.
21. Atkinson G, Batterham AM, Black MA, Cable NT, Hopkins ND, Dawson EA, Thijssen DH, Jones H, Tinken TM, Green DJ. Is the ratio of flow-mediated dilation and shear rate a statistically sound approach to normalization in cross-sectional studies on endothelial function? J Appl Physiol. 2009;107:1893-1899.
22. Parker BA, Trehearn TL, Meendering JR. Pick your Poiseuille: normalizing the shear stimulus in studies of flow-mediated dilation. J Appl Physiol. 2009;107:1357-1359.
23. Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P, Deanfield JE, MacAllister RJ. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res. 2001;88:145-151. (Pubitemid 32147301)