Thrombin generation assays (TGAs)

Methods in Molecular Biology

Volumn 1646, Issue , 2017, Pages 515-522

  Salvagno, Gian Luca ^a   Berntorp, Erik ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Coagulation; Hemophilia; Thrombin generation assay

Indexed keywords

ANTICOAGULANT AGENT; PROCOAGULANT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; THROMBIN;

ASSAY; FLUOROMETER; THROMBIN GENERATION ASSAY; BLEEDING; BLOOD; BLOOD CLOTTING; BLOOD CLOTTING TEST; FLUOROMETRY; HEMOPHILIA A; HEMOSTASIS; HUMAN; METABOLISM; PROCEDURES;

BLOOD COAGULATION; BLOOD COAGULATION TESTS; FLUOROMETRY; HEMOPHILIA A; HEMORRHAGE; HEMOSTASIS; HUMANS; INDICATORS AND REAGENTS; THROMBIN;

EID: 85027506642     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-7196-1_37     Document Type: Chapter

References (8)

1. Hemker HC, Willems GM, Beguin S (1986) A computer assisted method to obtain the prothrombin activation velocity in whole plasma independent of thrombin decay processes. Thromb Haemost 56:9–17
2. Hemker HC, Beguin S (1995) Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 74:134–138
3. Salvagno GL, Astermark J, Ekman M, Franchini M, Guidi GC, Lippi G, Poli G, Berntorp E (2007) Impact of different inhibitor reactivities with commercial factor VIII concentrates on thrombin generation. Haemophilia 13:51–56
4. Salvagno GL, Astermark J, Lippi G, Ekman M, Franchini M, Guidi GC, Berntorp E (2009) Thrombin generation assay: a useful routine check-up tool in the management of patients with haemophilia? Haemophilia 15:290–296
5. Berntorp E, Salvagno GL (2008) Standardization and clinical utility of thrombin-generation assays. Semin Thromb Hemost 34:670–682
6. Salvagno GL, Berntorp E (2010) Thrombin generation testing for monitoring hemophilia treatment: a clinical perspective. Semin Thromb Hemost 36:780–790
7. Váradi K, Negrier C, Berntorp E, Astermark J, Bordet JC, Morfini M, Linari S, Schwarz HP, Turecek PL (2003) Monitoring the bioavail-ability of FEIBA with a thrombin generation assay. J Thromb Haemost 1:2374–2380
8. Turecek PL, Váradi K, Keil B, Negrier C, Berntorp E, Astermark J, Bordet JC, Morfini M, Linari S, Schwarz HP (2003) Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay. Pathophysiol Haemost Thromb 33:16–22