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Volumn 17, Issue 1, 2017, Pages

Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: An open-label, single-arm, multicenter, pilot study

(23)  Honda, Yasushi a   Kessoku, Takaomi a   Sumida, Yoshio b   Kobayashi, Takashi a   Kato, Takayuki a   Ogawa, Yuji a   Tomeno, Wataru a   Imajo, Kento a   Fujita, Koji a   Yoneda, Masato a   Kataoka, Koshi a   Taguri, Masataka a   Yamanaka, Takeharu a   Seko, Yuya c   Tanaka, Saiyu d   Saito, Satoru a   Ono, Masafumi e   Oeda, Satoshi f   Eguchi, Yuichiro f   Aoi, Wataru g   more..


Author keywords

Controlled attenuation parameter; Glutathione; Nonalcoholic fatty liver disease

Indexed keywords

ALANINE AMINOTRANSFERASE; FATTY ACID; FERRITIN; GLUTATHIONE; TRIACYLGLYCEROL;

EID: 85027101267     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/s12876-017-0652-3     Document Type: Article
Times cited : (79)

References (29)
  • 1
    • 0036116213 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis (NASH): where are we now and where are we going?
    • Day CP. Non-alcoholic steatohepatitis (NASH): where are we now and where are we going? Gut. 2002;50:585-8.
    • (2002) Gut , vol.50 , pp. 585-588
    • Day, C.P.1
  • 2
    • 56649123256 scopus 로고    scopus 로고
    • The epidemiology of nonalcoholic fatty liver disease: a global perspective
    • Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis. 2008;28:339-50.
    • (2008) Semin Liver Dis , vol.28 , pp. 339-350
    • Lazo, M.1    Clark, J.M.2
  • 3
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: summary of an AASLD single topic conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology. 2003;37:1202-19.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 4
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • Marchesini G, Bugianesi E, Forlani G, et al. Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology. 2003;37:917-23.
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 5
    • 84888022758 scopus 로고    scopus 로고
    • Obesity-associated nonalcoholic fatty liver disease
    • Yilmaz Y, Younossi ZM. Obesity-associated nonalcoholic fatty liver disease. Clin Liver Dis. 2014;18:19-31.
    • (2014) Clin Liver Dis , vol.18 , pp. 19-31
    • Yilmaz, Y.1    Younossi, Z.M.2
  • 6
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51:121-9.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 7
    • 3042802690 scopus 로고    scopus 로고
    • Glutathione: an overview of biosynthesis and modulation
    • Anderson ME. Glutathione: an overview of biosynthesis and modulation. Chem Biol Interact. 1998;111-112:1-14.
    • (1998) Chem Biol Interact , vol.111-112 , pp. 1-14
    • Anderson, M.E.1
  • 8
    • 0029084081 scopus 로고
    • Glutathione in the treatment of chronic fatty liver diseases
    • Dentico P, Volpe A, Buongiorno R, et al. Glutathione in the treatment of chronic fatty liver diseases. Recenti Prog Med. 1995;86:290-3. [in Italian]
    • (1995) Recenti Prog Med , vol.86 , pp. 290-293
    • Dentico, P.1    Volpe, A.2    Buongiorno, R.3
  • 9
    • 0029975907 scopus 로고    scopus 로고
    • High-dose antioxidant therapy during thrombolysis in patients with acute myocardial infarction
    • Altomare E, Colonna P, D'Agostino C, et al. High-dose antioxidant therapy during thrombolysis in patients with acute myocardial infarction. Curr Ther Res Clin Exp. 1996;57:131-41.
    • (1996) Curr Ther Res Clin Exp , vol.57 , pp. 131-141
    • Altomare, E.1    Colonna, P.2    D'Agostino, C.3
  • 10
    • 80052236410 scopus 로고    scopus 로고
    • Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers
    • Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011;17:827-33.
    • (2011) J Altern Complement Med , vol.17 , pp. 827-833
    • Allen, J.1    Bradley, R.D.2
  • 11
    • 84907484358 scopus 로고    scopus 로고
    • In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementation
    • Kovacs-Nolan J, Rupa P, Matsui T, et al. In vitro and ex vivo uptake of glutathione (GSH) across the intestinal epithelium and fate of oral GSH after in vivo supplementation. J Agric Food Chem. 2014;62:9499-506.
    • (2014) J Agric Food Chem , vol.62 , pp. 9499-9506
    • Kovacs-Nolan, J.1    Rupa, P.2    Matsui, T.3
  • 12
    • 84903785418 scopus 로고    scopus 로고
    • Increase in the protein-bound form of glutathione in human blood after the oral administration of glutathione
    • Park EY, Shimura N, Konishi T, et al. Increase in the protein-bound form of glutathione in human blood after the oral administration of glutathione. J Agric Food Chem. 2014;62:6183-9.
    • (2014) J Agric Food Chem , vol.62 , pp. 6183-6189
    • Park, E.Y.1    Shimura, N.2    Konishi, T.3
  • 13
    • 84945436270 scopus 로고    scopus 로고
    • Serum alanine aminotransferase predicts the histological course of non-alcoholic steatohepatitis in Japanese patients
    • Seko Y, Sumida Y, Tanaka S, et al. Serum alanine aminotransferase predicts the histological course of non-alcoholic steatohepatitis in Japanese patients. Hepatol Res. 2015;45:E53-61.
    • (2015) Hepatol Res , vol.45 , pp. E53-E61
    • Seko, Y.1    Sumida, Y.2    Tanaka, S.3
  • 14
    • 79251476847 scopus 로고    scopus 로고
    • Report of the committee on the classification and diagnostic criteria of diabetes mellitus
    • Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus, Seino Y, Nanjo K, Tajima, et al. Report of the committee on the classification and diagnostic criteria of diabetes mellitus. J Diabetes Investig. 2010;1:212-28.
    • (2010) J Diabetes Investig , vol.1 , pp. 212-228
    • Seino, Y.1    Nanjo, K.2    Tajima, K.3
  • 16
    • 9144249563 scopus 로고    scopus 로고
    • Transient elastography: a new noninvasive method for assessment of hepatic fibrosis
    • Sandrin L, Fourquet B, Hasquenoph JM, et al. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol. 2003;29:1705-13.
    • (2003) Ultrasound Med Biol , vol.29 , pp. 1705-1713
    • Sandrin, L.1    Fourquet, B.2    Hasquenoph, J.M.3
  • 17
    • 77951874018 scopus 로고    scopus 로고
    • NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. NASH CRN. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362:1675-85.
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 18
    • 85001114564 scopus 로고    scopus 로고
    • Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats
    • Zhou X, Han D, Xu R, et al. Glycine protects against high sucrose and high fat-induced non-alcoholic steatohepatitis in rats. Oncotarget. 2016;7:80223-37.
    • (2016) Oncotarget , vol.7 , pp. 80223-80237
    • Zhou, X.1    Han, D.2    Xu, R.3
  • 19
    • 85016333383 scopus 로고    scopus 로고
    • Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD
    • Mardinoglu A, Bjornson E, Zhang C, et al. Personal model-assisted identification of NAD+ and glutathione metabolism as intervention target in NAFLD. Mol Syst Biol. 2017;13:916.
    • (2017) Mol Syst Biol , vol.13 , pp. 916
    • Mardinoglu, A.1    Bjornson, E.2    Zhang, C.3
  • 20
    • 84859448472 scopus 로고    scopus 로고
    • Metabolic syndrome and risk factors for non-alcoholic fatty liver disease
    • Souza MR, Diniz Mde F, Medeiros-Filho JE, et al. Metabolic syndrome and risk factors for non-alcoholic fatty liver disease. Arq Gastroenterol. 2012;49:89-96.
    • (2012) Arq Gastroenterol , vol.49 , pp. 89-96
    • Souza, M.R.1    Diniz Mde, F.2    Medeiros-Filho, J.E.3
  • 21
    • 84924228363 scopus 로고    scopus 로고
    • Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism
    • Aoi W, Ogaya Y, Takami M, et al. Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism. J Int Soc Sports Nutr. 2015;12:7.
    • (2015) J Int Soc Sports Nutr , vol.12 , pp. 7
    • Aoi, W.1    Ogaya, Y.2    Takami, M.3
  • 22
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    • Valenti L, Fracanzani AL, Dongiovanni P, et al. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol. 2007;102:1251-8.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3
  • 23
    • 33846549431 scopus 로고    scopus 로고
    • Association of body iron stores with low molecular weight iron and oxidant damage of human atherosclerotic plaques
    • Lapenna D, Pierdomenico SD, Ciofani G, et al. Association of body iron stores with low molecular weight iron and oxidant damage of human atherosclerotic plaques. Free Radic Biol Med. 2007;42:492-8.
    • (2007) Free Radic Biol Med , vol.42 , pp. 492-498
    • Lapenna, D.1    Pierdomenico, S.D.2    Ciofani, G.3
  • 24
    • 40449120460 scopus 로고    scopus 로고
    • Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver
    • Dongiovanni P, Valenti L, Ludovica Fracanzani A, et al. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol. 2008;172:738-47.
    • (2008) Am J Pathol , vol.172 , pp. 738-747
    • Dongiovanni, P.1    Valenti, L.2    Ludovica Fracanzani, A.3
  • 25
    • 19944427642 scopus 로고    scopus 로고
    • Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality
    • Miller ER 3rd, Pastor-Barriuso R, Dalal D, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. 2005;142:37-46.
    • (2005) Ann Intern Med , vol.142 , pp. 37-46
    • Miller, E.R.1    Pastor-Barriuso, R.2    Dalal, D.3
  • 26
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
    • Bjelakovic G, Nikolova D, Gluud LL, et al. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297:842-57.
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3
  • 27
    • 80053954605 scopus 로고    scopus 로고
    • Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT)
    • Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the selenium and vitamin E cancer prevention trial (SELECT). JAMA. 2011;306:1549-56.
    • (2011) JAMA , vol.306 , pp. 1549-1556
    • Klein, E.A.1    Thompson, I.M.2    Tangen, C.M.3
  • 28
    • 84900556498 scopus 로고    scopus 로고
    • Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: a meta-analysis of diagnostic accuracy
    • Shi KQ, Tang JZ, Zhu XL, et al. Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: a meta-analysis of diagnostic accuracy. J Gastroenterol Hepatol. 2014;29:1149-58.
    • (2014) J Gastroenterol Hepatol , vol.29 , pp. 1149-1158
    • Shi, K.Q.1    Tang, J.Z.2    Zhu, X.L.3
  • 29
    • 85027099028 scopus 로고    scopus 로고
    • Pharmaceutical Interview Form, Japan Standard Commodity No. 873922
    • Pharmaceutical Interview Form, Japan Standard Commodity No. 873922, 2014.
    • (2014)


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