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Volumn 8, Issue 4, 2017, Pages 727-738

Effects of Insulin Plus Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RAs) in Treating Type 1 Diabetes Mellitus: A Systematic Review and Meta-Analysis

Author keywords

Glucagon like peptide 1 receptor agonists (GLP 1RAs); Insulin; Meta analysis; Type 1 diabetes (T1DM)

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; INSULIN; LIRAGLUTIDE;

EID: 85027075033     PISSN: 18696953     EISSN: 18696961     Source Type: Journal    
DOI: 10.1007/s13300-017-0282-3     Document Type: Review
Times cited : (46)

References (35)
  • 1
    • 1642443489 scopus 로고    scopus 로고
    • Type 1 diabetes: recent developments[J]
    • PID: 15044291
    • Devendra D, Liu E, Eisenbarth GS, et al. Type 1 diabetes: recent developments[J]. BMJ. 2004;328(7442):750–4.
    • (2004) BMJ , vol.328 , Issue.7442 , pp. 750-754
    • Devendra, D.1    Liu, E.2    Eisenbarth, G.S.3
  • 2
    • 0028883204 scopus 로고
    • Failure of glucagon suppression contributes to postprandial hyperglycemia in IDDM[J]
    • COI: 1:STN:280:DyaK2M3nvVKlsQ%3D%3D, PID: 7758881
    • Dinneen S, Alzaid A, Turk D, et al. Failure of glucagon suppression contributes to postprandial hyperglycemia in IDDM[J]. Diabetologia. 1995;38(3):337–43.
    • (1995) Diabetologia , vol.38 , Issue.3 , pp. 337-343
    • Dinneen, S.1    Alzaid, A.2    Turk, D.3
  • 3
    • 0027370108 scopus 로고
    • The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
    • The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329:977–86.
    • (1993) N Engl J Med , vol.329 , pp. 977-986
  • 4
    • 79959415768 scopus 로고    scopus 로고
    • Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function
    • COI: 1:CAS:528:DC%2BC3MXmsVKlu7Y%3D, PID: 21441444
    • Kielgast U, Holst JJ, Madsbad S. Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function. Diabetes. 2011;60:1599–607.
    • (2011) Diabetes , vol.60 , pp. 1599-1607
    • Kielgast, U.1    Holst, J.J.2    Madsbad, S.3
  • 5
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and non diabetic subjects
    • COI: 1:CAS:528:DC%2BD3sXhtFans7w%3D, PID: 12540611
    • Kjems LL, Holst JJ, Madsbad S, et al. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and non diabetic subjects. Diabetes. 2003;52:380–6.
    • (2003) Diabetes , vol.52 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Madsbad, S.3
  • 6
    • 84919344081 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC2MXmtVSrug%3D%3D, PID: 25220191
    • Eng C, Kramer CK, Zinman B, Retnakaran R. Glucagon-like peptide-1 receptor agonist and basal insulin combination treatment for the management of type 2 diabetes: a systematic review and meta-analysis. Lancet. 2014;384:2228–34.
    • (2014) Lancet , vol.384 , pp. 2228-2234
    • Eng, C.1    Kramer, C.K.2    Zinman, B.3    Retnakaran, R.4
  • 7
    • 0034522773 scopus 로고    scopus 로고
    • Glugacon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose intolerant rats[J]
    • Peffetti R, Zhou J, Doyle ME, et al. Glugacon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose intolerant rats[J]. Endocrinology. 2000;141(12):4600–5.
    • (2000) Endocrinology , vol.141 , Issue.12 , pp. 4600-4605
    • Peffetti, R.1    Zhou, J.2    Doyle, M.E.3
  • 8
    • 69449100622 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
    • PID: 19622551
    • Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.
    • (2009) BMJ , vol.339 , pp. b2535
    • Moher, D.1    Liberati, A.2    Tetzlaff, J.3    Altman, D.G.4
  • 9
  • 10
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • PID: 12111919
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.
    • (2002) Stat Med , vol.21 , pp. 1539-1558
    • Higgins, J.P.1    Thompson, S.G.2
  • 11
    • 85027015756 scopus 로고    scopus 로고
    • One-year effects of liraglutide on pancreatic beta cell function and glycemic control in Japanese type 1 diabetes with residual insulin secretion
    • Hamamoto Y, Mori K, Honjo S, et al. One-year effects of liraglutide on pancreatic beta cell function and glycemic control in Japanese type 1 diabetes with residual insulin secretion. Diabetologia. 2012;55:S300.
    • (2012) Diabetologia , vol.55 , pp. S300
    • Hamamoto, Y.1    Mori, K.2    Honjo, S.3
  • 12
    • 84959481026 scopus 로고    scopus 로고
    • Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycemic control(Lira-1):a randomized, double-blind, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BC28XhtFCisbfJ, PID: 26656289
    • Dejgaard TF, Frandsen CS, Hansen TS, et al. Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycemic control(Lira-1):a randomized, double-blind, placebo-controlled trial. Lancet Diabetes Endocrinol. 2016;4:221–32.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 221-232
    • Dejgaard, T.F.1    Frandsen, C.S.2    Hansen, T.S.3
  • 13
    • 84878349609 scopus 로고    scopus 로고
    • Addition of exenatide or sitagliptin to insulin in new onset type 1 diabetes: a randomized, open label study
    • COI: 1:CAS:528:DC%2BC3sXktlGjtLs%3D, PID: 23490599
    • Hari Kumar KV, Shaikh A, Prusty P. Addition of exenatide or sitagliptin to insulin in new onset type 1 diabetes: a randomized, open label study. Diabetes Res Clin Pract. 2013;100:e55–8.
    • (2013) Diabetes Res Clin Pract , vol.100 , pp. e55-e58
    • Hari Kumar, K.V.1    Shaikh, A.2    Prusty, P.3
  • 14
    • 84962433174 scopus 로고    scopus 로고
    • Twelve-week treatment with liraglutide as add-on to insulin in normal-weight patients with poorly controlled type 1 diabetes: a randomized, placebo-controlled, double-blind parallel study
    • COI: 1:CAS:528:DC%2BC28XntVWjtbo%3D, PID: 26486191
    • Frandsen CS, Dejgaard TF, Holst JJ, et al. Twelve-week treatment with liraglutide as add-on to insulin in normal-weight patients with poorly controlled type 1 diabetes: a randomized, placebo-controlled, double-blind parallel study. Diabetes Care. 2015;38:2250–7.
    • (2015) Diabetes Care , vol.38 , pp. 2250-2257
    • Frandsen, C.S.1    Dejgaard, T.F.2    Holst, J.J.3
  • 15
    • 84896702500 scopus 로고    scopus 로고
    • Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes
    • COI: 1:CAS:528:DC%2BC2cXmvF2kurc%3D, PID: 24194508
    • Sarkar G, Alattar M, Brown RJ, et al. Exenatide treatment for 6 months improves insulin sensitivity in adults with type 1 diabetes. Diabetes Care. 2014;37:666–70.
    • (2014) Diabetes Care , vol.37 , pp. 666-670
    • Sarkar, G.1    Alattar, M.2    Brown, R.J.3
  • 16
    • 72249103423 scopus 로고    scopus 로고
    • Effects of exenatide alone and in combination with daclizumab on β-cell function in long-standing type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3cXktlWqtA%3D%3D, PID: 19808924
    • Rother KI, Spain LM, Wesley RA, et al. Effects of exenatide alone and in combination with daclizumab on β-cell function in long-standing type 1 diabetes. Diabetes Care. 2009;32:2251–7.
    • (2009) Diabetes Care , vol.32 , pp. 2251-2257
    • Rother, K.I.1    Spain, L.M.2    Wesley, R.A.3
  • 17
    • 84971249932 scopus 로고    scopus 로고
    • Addition of liraglutide to insulin in patients with type 1 diabetes: a randomized placebo-controlled clinical trial of 12 weeks
    • COI: 1:CAS:528:DC%2BC28XhsFGitbzJ, PID: 27208343
    • Kuhadiya ND, Dhindsa S, Ghanim H, et al. Addition of liraglutide to insulin in patients with type 1 diabetes: a randomized placebo-controlled clinical trial of 12 weeks. Diabetes Care. 2016;39:1027–35.
    • (2016) Diabetes Care , vol.39 , pp. 1027-1035
    • Kuhadiya, N.D.1    Dhindsa, S.2    Ghanim, H.3
  • 18
    • 84860764300 scopus 로고    scopus 로고
    • Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes
    • COI: 1:CAS:528:DC%2BC38XntV2isb4%3D, PID: 22362823
    • Bergman BC, Howard D, Schauer IE, et al. Features of hepatic and skeletal muscle insulin resistance unique to type 1 diabetes. J Clin Endocrinol Metab. 2012;97:1663–72.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 1663-1672
    • Bergman, B.C.1    Howard, D.2    Schauer, I.E.3
  • 19
    • 0036496551 scopus 로고    scopus 로고
    • Exendin4 increases insulin sensitivity via PI-3-kinases-dependent mechanism: contrasting effects of GLP-1
    • COI: 1:CAS:528:DC%2BD38XitFWls7g%3D, PID: 11911852
    • Idris I, Patiag D, Gray S, Donnelly R. Exendin4 increases insulin sensitivity via PI-3-kinases-dependent mechanism: contrasting effects of GLP-1. Biochem Pharmacol. 2002;63:993–6.
    • (2002) Biochem Pharmacol , vol.63 , pp. 993-996
    • Idris, I.1    Patiag, D.2    Gray, S.3    Donnelly, R.4
  • 20
    • 15444380712 scopus 로고    scopus 로고
    • Exenatide(exendin-4) improves insulin sensitivity and beta-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight
    • COI: 1:CAS:528:DC%2BD2MXis1yqu7k%3D, PID: 15618356
    • Gedulin BR, Nikoulina SE, Smith PA, et al. Exenatide(exendin-4) improves insulin sensitivity and beta-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight. Endocrinology. 2005;146:2069–76.
    • (2005) Endocrinology , vol.146 , pp. 2069-2076
    • Gedulin, B.R.1    Nikoulina, S.E.2    Smith, P.A.3
  • 21
    • 15744381238 scopus 로고    scopus 로고
    • The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro
    • COI: 1:CAS:528:DC%2BD2MXis1Grsr4%3D
    • Bregenholt S, Moldrup A, Blume N, et al. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro. Biochem Biophy Res Commun. 2005;330:577–84.
    • (2005) Biochem Biophy Res Commun , vol.330 , pp. 577-584
    • Bregenholt, S.1    Moldrup, A.2    Blume, N.3
  • 22
    • 0345374580 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
    • COI: 1:CAS:528:DC%2BD3sXpsV2gt7g%3D, PID: 12960095
    • Farilla L, Bulotta A, Hirshberg B, et al. Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets. Endocrinology. 2003;144:5149–58.
    • (2003) Endocrinology , vol.144 , pp. 5149-5158
    • Farilla, L.1    Bulotta, A.2    Hirshberg, B.3
  • 23
    • 0029954211 scopus 로고    scopus 로고
    • Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptidel(7-36)amide in type 1 diabetic patients
    • COI: 1:STN:280:DyaK28zkvVyisg%3D%3D, PID: 8725855
    • Creutzfeldt WO, Kleine N, Willms B, et al. Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptidel(7-36)amide in type 1 diabetic patients. Diabetes Care. 1996;19:580–6.
    • (1996) Diabetes Care , vol.19 , pp. 580-586
    • Creutzfeldt, W.O.1    Kleine, N.2    Willms, B.3
  • 24
    • 0026596851 scopus 로고
    • Antidiabetogenic effect of glucagon-like peptide-1(7-36)amide in normal subjects and patients with diabetes mellitus
    • COI: 1:STN:280:DyaK383ivVShtg%3D%3D, PID: 1348845
    • Gutniak M, Orskov C, Holst JJ, et al. Antidiabetogenic effect of glucagon-like peptide-1(7-36)amide in normal subjects and patients with diabetes mellitus. N Engl J Med. 1992;326:1316–22.
    • (1992) N Engl J Med , vol.326 , pp. 1316-1322
    • Gutniak, M.1    Orskov, C.2    Holst, J.J.3
  • 25
    • 1842598583 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 improved glycemic control in type 1 diabetes
    • Behme MT, Dupre J, McDonald TJ, et al. Glucagon-like peptide 1 improved glycemic control in type 1 diabetes. BMC Endocr Disord. 2003;10:1–9.
    • (2003) BMC Endocr Disord , vol.10 , pp. 1-9
    • Behme, M.T.1    Dupre, J.2    McDonald, T.J.3
  • 26
    • 79959392262 scopus 로고    scopus 로고
    • Liraglutide as additional treatment for type 1 diabetes
    • COI: 1:CAS:528:DC%2BC3MXps1Sls74%3D, PID: 21646283
    • Varanasi A, Bellini N, Rawal D, et al. Liraglutide as additional treatment for type 1 diabetes. Eur J Endocrinol. 2011;165:77–84.
    • (2011) Eur J Endocrinol , vol.165 , pp. 77-84
    • Varanasi, A.1    Bellini, N.2    Rawal, D.3
  • 27
    • 84873642385 scopus 로고    scopus 로고
    • Type 1 diabetes treatment beyond insulin: role of GLP-1 analogs
    • COI: 1:CAS:528:DC%2BC3sXjsVKlsrc%3D, PID: 23222002
    • Harrison LB, Mora PF, Clark GO, Lingvay I. Type 1 diabetes treatment beyond insulin: role of GLP-1 analogs. J Investig Med. 2013;61:40–4.
    • (2013) J Investig Med , vol.61 , pp. 40-44
    • Harrison, L.B.1    Mora, P.F.2    Clark, G.O.3    Lingvay, I.4
  • 28
    • 0142057121 scopus 로고    scopus 로고
    • Obesity and health-related quality of life: a cross-sectional analysis of the US population
    • COI: 1:STN:280:DC%2BD3svltVejtw%3D%3D
    • Hassan MK, Joshi AV, Madhavan SS, Amonkar MM. Obesity and health-related quality of life: a cross-sectional analysis of the US population. Int J Obes Relat Metab Discord. 2003;27:1227–32.
    • (2003) Int J Obes Relat Metab Discord , vol.27 , pp. 1227-1232
    • Hassan, M.K.1    Joshi, A.V.2    Madhavan, S.S.3    Amonkar, M.M.4
  • 29
    • 0026502045 scopus 로고
    • Natural course of remission in IDDM during 1st yr after diagnosis
    • COI: 1:STN:280:DyaK387ks1ajsQ%3D%3D, PID: 1737543
    • Martin S, Pawlowski B, Greulich B, et al. Natural course of remission in IDDM during 1st yr after diagnosis. Diabetes Care. 1992;15:66–74.
    • (1992) Diabetes Care , vol.15 , pp. 66-74
    • Martin, S.1    Pawlowski, B.2    Greulich, B.3
  • 30
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • COI: 1:CAS:528:DC%2BD2sXhtlaqu7jI, PID: 17928588
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007;87:1409–39.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 31
    • 80054690193 scopus 로고    scopus 로고
    • Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function
    • COI: 1:CAS:528:DC%2BC3MXhtFWlsrnE, PID: 21593296
    • Kielgast U, Krarup T, Holst JJ, Madsbad S. Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual beta-cell function. Diabetes Care. 2011;34:1463–8.
    • (2011) Diabetes Care , vol.34 , pp. 1463-1468
    • Kielgast, U.1    Krarup, T.2    Holst, J.J.3    Madsbad, S.4
  • 32
    • 84888860571 scopus 로고    scopus 로고
    • Liraglutide as additional treatment to insulin in obese patients with type 1 diabetes mellitus
    • PID: 23807520
    • Kuhadiya ND, Malik R, Bellini NJ, et al. Liraglutide as additional treatment to insulin in obese patients with type 1 diabetes mellitus. Endocr Pract. 2013;19:963–7.
    • (2013) Endocr Pract , vol.19 , pp. 963-967
    • Kuhadiya, N.D.1    Malik, R.2    Bellini, N.J.3
  • 33
    • 35148814453 scopus 로고    scopus 로고
    • Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin
    • PID: 17872344
    • Viswanathan P, Chaudhuri A, Bhatia R, et al. Exenatide therapy in obese patients with type 2 diabetes mellitus treated with insulin. Endocr Pract. 2007;13:444–50.
    • (2007) Endocr Pract , vol.13 , pp. 444-450
    • Viswanathan, P.1    Chaudhuri, A.2    Bhatia, R.3
  • 34
    • 84914666192 scopus 로고    scopus 로고
    • Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXhsFWhurnK, PID: 24980665
    • Ferdinand KC, White WB, Calhoun DA, et al. Effects of the once-weekly glucagon-like peptide-1 receptor agonist dulaglutide on ambulatory blood pressure and heart rate in patients with type 2 diabetes mellitus. Hypertension. 2014;64:731–7.
    • (2014) Hypertension , vol.64 , pp. 731-737
    • Ferdinand, K.C.1    White, W.B.2    Calhoun, D.A.3
  • 35
    • 78851471129 scopus 로고    scopus 로고
    • Liraglutide-overview of the preclinical and clinical data and its role in the treatment of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXjtFSgsbY%3D, PID: 21205109
    • Davies MJ, Kela R, Khunti K. Liraglutide-overview of the preclinical and clinical data and its role in the treatment of type 2 diabetes. Diabetes Obes Metab. 2011;13:207–20.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 207-220
    • Davies, M.J.1    Kela, R.2    Khunti, K.3


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