Enhanced protection against experimental Junin virus infection through the use of a modified favipiravir loading dose strategy

Antiviral Research

Volumn 145, Issue , 2017, Pages 131-135

  Gowen, Brian B ^a   Westover, Jonna B ^a   Sefing, Eric J ^a   Van Wettere, Arnaud J ^a,b   Bailey, Kevin W ^a   Wandersee, Luci ^a   Komeno, Takashi ^c   Furuta, Yousuke ^c  

^a UTAH STATE UNIVERSITY   (United States)

^b Utah Veterinary Diagnostic Laboratory   (United States)

^c TOYAMA CHEMICAL CO LTD   (Japan)

Author keywords

Arenavirus; Favipiravir; Junin virus; T 705; Viral hemorrhagic fever

Indexed keywords

FAVIPIRAVIR; PLACEBO; AMIDE; ANTIVIRUS AGENT; PYRAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARGENTINE HEMORRHAGIC FEVER; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; CONTROLLED STUDY; DISEASE COURSE; DRUG MEGADOSE; EXPERIMENTAL INFECTION; GUINEA PIG MODEL; HISTOPATHOLOGY; JUNIN VIRUS; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTECTION; SURVIVAL TIME; TREATMENT OUTCOME; VIREMIA; VIRUS LOAD; VIRUS TITRATION; AMERICAN HEMORRHAGIC FEVER; ANIMAL; BLOOD; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GUINEA PIG; SURVIVAL ANALYSIS;

AMIDES; ANIMALS; ANTIVIRAL AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEMORRHAGIC FEVER, AMERICAN; JUNIN VIRUS; PYRAZINES; SURVIVAL ANALYSIS; VIRAL LOAD;

EID: 85026803822     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2017.07.019     Document Type: Article

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