Aberrant intestinal microbiota due to IL-1 receptor antagonist deficiency promotes IL-17- and TLR4-dependent arthritis

Microbiome

Volumn 5, Issue 1, 2017, Pages 63-

  Rogier, Rebecca ^a   Ederveen, Thomas H A ^a   Boekhorst, Jos ^a   Wopereis, Harm ^a,b   Scher, Jose U ^a   Manasson, Julia ^a   Frambach, Sanne J C M ^a   Knol, Jan ^a,b   Garssen, Johan ^b   van der Kraan, Peter M ^a   Koenders, Marije I ^a   van den Berg, Wim B ^a   van Hijum, Sacha A F T ^a   Abdollahi Roodsaz, Shahla ^a  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b DANONE NUTRICIA RESEARCH   (Netherlands)

Author keywords

Autoimmune arthritis; IL 1 receptor antagonist; Microbiota; T helper 17 cells; Toll like receptors

Indexed keywords

ANTIINFECTIVE AGENT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 17; RNA 16S; TOLL LIKE RECEPTOR 4;

ANIMAL; ARTHRITIS; AUTOIMMUNE DISEASE; DEFICIENCY; GENETIC VARIATION; GENETICS; HELICOBACTER; HEREDITARY PERIODIC FEVER; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; INTESTINE FLORA; INTESTINE MUCOSA; KNOCKOUT MOUSE; MICROBIOLOGY; MOUSE; MUCOSA; PHYSIOLOGY; PREVOTELLA; RUMINOCOCCUS; TH17 CELL;

ANIMALS; ANTI-BACTERIAL AGENTS; ARTHRITIS; AUTOIMMUNE DISEASES; GASTROINTESTINAL MICROBIOME; GENETIC VARIATION; HELICOBACTER; HEREDITARY AUTOINFLAMMATORY DISEASES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-17; INTESTINAL MUCOSA; MICE; MICE, KNOCKOUT; MUCOUS MEMBRANE; PREVOTELLA; RNA, RIBOSOMAL, 16S; RUMINOCOCCUS; TH17 CELLS; TOLL-LIKE RECEPTOR 4;

EID: 85026771773     PISSN: None     EISSN: 20492618     Source Type: Journal    
DOI: 10.1186/s40168-017-0278-2     Document Type: Article

References (0)