A case of TREM2 mutation presenting with features of progressive non-fluent aphasia and without bone involvement

Australian and New Zealand Journal of Psychiatry

Volumn 51, Issue 11, 2017, Pages 1157-1158

  Chee, Kok Yoon ^a   Gaillard, Frank ^b,c   Velakoulis, Dennis ^b   Ang, Chong Lip ^d   Chin, Loi Khim ^a   Ariffin, Roziana ^a  

^a HOSPITAL KUALA LUMPUR   (Malaysia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d HOSPITAL RAJA PERMAISURI BAINUN   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN;

ADULT; APATHY; APHASIA; AUTOSOMAL RECESSIVE DISORDER; BONE CYST; BRAIN VENTRICLE DILATATION; CASE REPORT; CLINICAL ARTICLE; COGNITION; COGNITION ASSESSMENT; DEMENTIA; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENERAL CONDITION DETERIORATION; GENETIC ANALYSIS; HUMAN; INTRON; LETTER; MAJOR DEPRESSION; NASU HAKOLA DISEASE; NEUROPSYCHIATRY; NUCLEAR MAGNETIC RESONANCE IMAGING; PROGRESSIVE NON FLUENT APHASIA; TREM2 GENE; GENETICS; MUTATION; PATHOLOGY; PATHOPHYSIOLOGY; PROGRESSIVE NONFLUENT APHASIA;

ADULT; DEMENTIA; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; MUTATION; PRIMARY PROGRESSIVE NONFLUENT APHASIA; RECEPTORS, IMMUNOLOGIC;

EID: 85026672318     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1177/0004867417707821     Document Type: Letter

References (3)

1. Chouery E, Delague V, Bergougnoux A. (2008) Mutations in TREM2 lead to pure early-onset dementia without bone cysts. Human Mutation 29: E194–E204.
2. Guerreiro RJ, Lohmann E, Brás JM. (2013) Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia–like syndrome without bone involvement. JAMA Neurology 70: 78–84.
3. Mesulam MM, (2003) Primary progressive aphasia – A language-based dementia. The New England Journal of Medicine 349: 1535–1542.