TREM2 p.R47H substitution is not associated with dementia with Lewy bodies

Neurology: Genetics

Volumn 2, Issue 4, 2016, Pages

  Walton, Ronald L ^a,b   Soto Ortolaza, Alexandra I ^a   Murray, Melissa E ^b   Lorenzo Betancor, Oswaldo ^b,c,d   Ogaki, Kotaro ^a   Heckman, Michael G ^b,d   Rayaprolu, Sruti ^a   Rademakers, Rosa ^c,d   Ertekin Taner, Nilüfer ^a   Uitti, Ryan J ^d   Van Gerpen, Jay A ^a   Wszolek, Zbigniew K ^d   Smith, Glenn E ^d   Kantarci, Kejal ^a   Lowe, Val J ^d   Parisi, Joseph E ^a   Jones, David T ^a   Savica, Rodolfo ^d   Graff Radford, Jonathan ^f   Knopman, David S ^e   Petersen, Ronald C ^a   Graff Radford, Neill R ^a   Ferman, Tanis J ^b   Dickson, Dennis W ^a   Boeve, Bradley F ^a,b   Ross, Owen A ^a,b,c   Labbé, Catherine ^a,b   more..

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF NORTH FLORIDA   (United States)

^d Department of Radiology ^*  (United States)

^e MAYO CLINIC   (United States)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2;

BONE MARROW CELL; BRAIN STEM; CONSENSUS; DIFFUSE LEWY BODY DISEASE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC ASSOCIATION STUDY; GENETIC RISK; GENOTYPE; HUMAN; NOTE; PRIORITY JOURNAL; RISK FACTOR;

EID: 85026626497     PISSN: None     EISSN: 23767839     Source Type: Journal    
DOI: 10.1212/NXG.0000000000000085     Document Type: Note

References (7)

1. Ferman TJ, Boeve BF, Smith GE, et al. Inclusion of RBD improves the diagnostic classification of dementia with Lewy bodies. Neurology 2011;77:875-882.
2. McKeith IG, Galasko D, Kosaka K, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 1996;47:1113-1124.
3. Bras J, Guerreiro R, Darwent L, et al. Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies. Hum Mol Genet 2014;23:6139-6146.
4. Benitez BA, Cruchaga C. TREM2 and neurodegenerative disease. N Engl J Med 2013;369:1567-1568.
5. Rayaprolu S, Mullen B, Baker M, et al. TREM2 in neuro-degeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Mol Neurodegener 2013;8:19.
6. Lill CM, Rengmark A, Pihlstrom L, et al. The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease. Alzheimers Dement 2015;11:1407-1416.
7. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology 2005;65:1863-1872.