Glutaminase inhibitor CB-839 synergizes with carfilzomib in resistant multiple myeloma cells

Oncotarget

Volumn 8, Issue 22, 2017, Pages 35863-35876

  Thompson, Ravyn M ^a   Dytfeld, Dominik ^b   Reyes, Leticia ^a   Robinson, Reeder M ^a   Smith, Brittany ^a   Manevich, Yefim ^a   Jakubowiak, Andrzej ^c   Komarnicki, Mieczyslaw ^b   Przybylowicz Chalecka, Anna ^b   Szczepaniak, Tomasz ^b   Mitra, Amit K ^d   Van Ness, Brian G ^d   Luczak, Magdalena ^e   Dolloff, Nathan G ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^c UNIVERSITY OF CHICAGO   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

Author keywords

carfilzomib; glutaminase; multiple myeloma; proteasome inhibitor

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENEACETAMIDE DERIVATIVE; BIOLOGICAL MARKER; CARFILZOMIB; CB-839; GLUTAMINASE; OLIGOPEPTIDE; PROTEASOME INHIBITOR; THIADIAZOLE DERIVATIVE;

AGED; APOPTOSIS; CELL RESPIRATION; CELL SURVIVAL; DRUG EFFECT; DRUG POTENTIATION; DRUG RESISTANCE; ENDOPLASMIC RETICULUM STRESS; ENERGY METABOLISM; HUMAN; METABOLISM; MITOCHONDRION; MULTIPLE MYELOMA; PATHOLOGY; TUMOR CELL LINE;

AGED; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BENZENEACETAMIDES; BIOMARKERS; CELL LINE, TUMOR; CELL RESPIRATION; CELL SURVIVAL; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ENDOPLASMIC RETICULUM STRESS; ENERGY METABOLISM; GLUTAMINASE; HUMANS; MITOCHONDRIA; MULTIPLE MYELOMA; OLIGOPEPTIDES; PROTEASOME INHIBITORS; THIADIAZOLES;

EID: 85026230339     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16262     Document Type: Article

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