Interleukin-6: An early predictive marker for severity of acute pancreatitis

Indian Journal of Critical Care Medicine

Volumn 21, Issue 7, 2017, Pages 424-428

  Rao, Shilpa A ^a   Kunte, Aditya R ^a  

^a KEM HOSPITAL   (India)

Author keywords

Inflammatory cytokines; interleukins; predictive markers; severe acute pancreatitis

Indexed keywords

ANTIBIOTIC AGENT; C REACTIVE PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8;

ACUTE PANCREATITIS; ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL OUTCOME; COHORT ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; DISEASE SEVERITY ASSESSMENT; FEMALE; HEALTH CARE QUALITY; HUMAN; LABORATORY TEST; MALE; PANCREATIC INSUFFICIENCY; PATIENT MONITORING; PREDICTIVE VALUE; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY;

EID: 85025149232     PISSN: 09725229     EISSN: 1998359X     Source Type: Journal    
DOI: 10.4103/ijccm.IJCCM_478_16     Document Type: Article

References (29)

1. Bollen TL, van Santvoort HC, Besselink MG, van Leeuwen MS, Horvath KD, Freeny PC, et al. The Atlanta classification of acute pancreatitis revisited. Br J Surg 2008;95:6-21.
2. Ranson JH, Rifkind KM, Turner JW. Prognostic signs and nonoperative peritoneal lavage in acute pancreatitis. Surg Gynecol Obstet 1976;143:209-19.
3. Ranson JH, Pasternack BS. Statistical methods for quantifying the severity of clinical acute pancreatitis. J Surg Res 1977;22:79-91.
4. Ranson JH. The timing of biliary surgery in acute pancreatitis. Ann Surg 1979;189:654-63.
5. Blamey SL, Imrie CW, O'Neill J, Gilmour WH, Carter DC. Prognostic factors in acute pancreatitis. Gut 1984;25:1340-6.
6. Wilson C, Heath Di, Imrie CW. Prediction of outcome in acute pancreatitis: A comparative study of APACHE II, clinical assessment and multiple factor scoring systems. Br J Surg 1990;77:1260-4.
7. Wilson C, Heads A, Shenkin A, Imrie CW. C-reactive protein, antiproteases and complement factors as objective markers of severity in acute pancreatitis. Br J Surg 1989;76:177-81.
8. McMahon MJ, Playforth MJ, Pickford IR. A compaative study of methods for the prediction of severity of attacks of acute pancreatitis. Br J Surg 1980;67:22-5.
9. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: A severity of disease classification system. Crit Care Med 1985;13:818-29.
10. Stimac D, Fisic E, Milic S, Bilic-Zulle L, Peric R. Prognostic values of IL-6, IL-8, and IL-10 in acute pancreatitis. J Clin Gastroenterol 2006;40:209-12.
11. Pederzoli P, Bassi C, Vesentini S, Campedelli A. A randomized multicenter clinical trial of antibiotic prophylaxis of septic complications in acute necrotizing pancreatitis with imipenem. Surg Gynecol Obstet 1993;176:480-3.
12. Sainio V, Kemppainen E, Puolakkainen P, Taavitsainen M, Kivisaari L, Valtonen V, et al. Early antibiotic treatment in acute necrotising pancreatitis. Lancet 1995;346:663-7.
13. Neoptolemos JP, Carr-Locke DL, London NJ, Bailey IA, James D, Fossard DP. Controlled trial of urgent endoscopic retrograde cholangiopancreatography and endoscopic sphincterotomy versus conservative treatment for acute pancreatitis due to gallstones. Lancet 1988;2:979-83.
14. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med 1995;23:1638-52.
15. Schölmerich J. Interleukins in acute pancreatitis. Scand J Gastroenterol Suppl 1996;219:37-42.
16. Viedma JA, Pérez-Mateo M, Domínguez JE, Carballo F. Role of interleukin-6 in acute pancreatitis. Comparison with C-reactive protein and phospholipase A. Gut 1992;33:1264-7.
17. Gross V, Leser HG, Heinisch A, Schölmerich J. Inflammatory mediators and cytokines-New aspects of the pathophysiology and assessment of severity of acute pancreatitis? Hepatogastroenterology 1993;40:522-30.
18. McKay CJ, Gallagher G, Brooks B, Imrie CW, Baxter JN. Increased monocyte cytokine production in association with systemic complications in acute pancreatitis. Br J Surg 1996;83:919-23.
19. Heath Di, Cruickshank A, Gudgeon M, Jehanli A, Shenkin A, Imrie CW. Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. Gut 1993;34:41-5.
20. Pezzilli R, Billi P, Miniero R, Fiocchi M, Cappelletti O, Morselli-Labate AM, et al. Serum interleukin-6, interleukin-8, and beta 2-microglobulin in early assessment of severity of acute pancreatitis. Comparison with serum C-reactive protein. Dig Dis Sci 1995;40:2341-8.
21. Pooran N, Indaram A, Singh P, Bank S. Cytokines (IL-6, IL-8, TNF): Early and reliable predictors of severe acute pancreatitis. J Clin Gastroenterol 2003;37:263-6.
22. Rau B, Steinbach G, Gansauge F, Mayer JM, Grünert A, Beger HG. The potential role of procalcitonin and interleukin 8 in the prediction of infected necrosis in acute pancreatitis. Gut 1997;41:832-40.
23. Pezzilli R, Miniero R, Cappelletti O, Barakat B. Serum interleukin 6 in the prognosis of acute biliary pancreatitis. Ital J Gastroenterol Hepatol 1998;30:291-4.
24. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045-9.
25. Hack CE, Hart M, van Schijndel RJ, Eerenberg AJ, Nuijens JH, Thijs LG, et al. Interleukin-8 in sepsis: Relation to shock and inflammatory mediators. Infect Immun 1992;60:2835-42.
26. Gross V, Andreesen R, Leser HG, Ceska M, Liehl E, Lausen M, et al. Interleukin-8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest 1992;22:200-3.
27. Kasama T, Strieter RM, Lukacs NW, Burdick MD, Kunkel SL. Regulation of neutrophil-derived chemokine expression by IL-10. J Immunol 1994;152:3559-69.
28. Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW. Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 1997;112:960-7.
29. Fisic E, Poropat G, Bilic-Zulle L, Licul V, Milic S, Stimac D. The role of IL-6, 8, and 10, sTNFr, CRP, and pancreatic elastase in the prediction of systemic complications in patients with acute pancreatitis. Gastroenterol Res Pract 2013;2013:282645.