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Volumn 116, Issue , 2017, Pages 68-81

Third-line systemic treatment versus best supportive care for advanced/metastatic gastric cancer: A systematic review and meta-analysis

Author keywords

Chemotherapy; Gastric cancer; Metastatic; Palliative care; Targeted therapy

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTINEOPLASTIC AGENT; APATINIB; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DOCETAXEL; EVEROLIMUS; GAMMA GLUTAMYLTRANSFERASE; IRINOTECAN; LACTATE DEHYDROGENASE; REGORAFENIB; UNCLASSIFIED DRUG;

EID: 85024923239     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2017.05.002     Document Type: Review
Times cited : (34)

References (38)
  • 1
    • 84937041504 scopus 로고    scopus 로고
    • Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012
    • Bang, Y.J., Chung, H.C., Shankaran, V., Geva, R., Catenacci, D.V.T., Gupta, S., Eder, J.P., Berger, R., Gonzalez, E.J., Ray, A., et al. Relationship between PD-L1 expression and clinical outcomes in patients with advanced gastric cancer treated with the anti-PD-1 monoclonal antibody pembrolizumab (MK-3475) in KEYNOTE-012. J. Clin. Oncol., 33(Suppl. 15), 2015, 4001.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 4001
    • Bang, Y.J.1    Chung, H.C.2    Shankaran, V.3    Geva, R.4    Catenacci, D.V.T.5    Gupta, S.6    Eder, J.P.7    Berger, R.8    Gonzalez, E.J.9    Ray, A.10
  • 2
    • 5344256928 scopus 로고    scopus 로고
    • European Organisation for Research and Treatment of Cancer Gastrointestinal and Quality of Life Groups. Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-STO 22, to assess quality of life in patients with gastric cancer
    • Blazeby, J.M., Conroy, T., Bottomley, A., Vickery, C., Arraras, J., Sezer, O., et al. European Organisation for Research and Treatment of Cancer Gastrointestinal and Quality of Life Groups. Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-STO 22, to assess quality of life in patients with gastric cancer. Eur. J. Cancer 40:October (15) (2004), 2260–2268.
    • (2004) Eur. J. Cancer , vol.40 , Issue.October (15) , pp. 2260-2268
    • Blazeby, J.M.1    Conroy, T.2    Bottomley, A.3    Vickery, C.4    Arraras, J.5    Sezer, O.6
  • 3
    • 84940594027 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, multicenter, placebo (P)-controlled trial of rilotumumab (R) plus epirubicin, cisplatin and capecitabine (ECX) as first-line therapy in patients (pts) with advanced MET-positive (pos) gastric or gastroesophageal junction (G/GEJ) cancer: RILOMET-1 study
    • Cunningham, D., Tebbutt, N.C., Davidenko, I., Murad, A.M., Al-Batran, S.-E., Ilson, D.H., et al. Phase III, randomized, double-blind, multicenter, placebo (P)-controlled trial of rilotumumab (R) plus epirubicin, cisplatin and capecitabine (ECX) as first-line therapy in patients (pts) with advanced MET-positive (pos) gastric or gastroesophageal junction (G/GEJ) cancer: RILOMET-1 study. J. Clin. Oncol., 33(Suppl. 15), 2015, 4000.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 4000
    • Cunningham, D.1    Tebbutt, N.C.2    Davidenko, I.3    Murad, A.M.4    Al-Batran, S.-E.5    Ilson, D.H.6
  • 4
    • 84942193846 scopus 로고    scopus 로고
    • A phase 3, multicenter, randomized, double-blind, placebo-controlled study of rilotumumab in combination with cisplatin and capecitabine (CX) as first-line therapy for Asian patients (pts) with advanced MET-positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: the RILOMET-2 trial
    • Doi, T., Kang, Y.K., Muro, K., Jiang, Y., Jain, R.K., Lizambri, R., A phase 3, multicenter, randomized, double-blind, placebo-controlled study of rilotumumab in combination with cisplatin and capecitabine (CX) as first-line therapy for Asian patients (pts) with advanced MET-positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: the RILOMET-2 trial. J. Clin. Oncol., 33(Suppl. 15), 2015, TPS226.
    • (2015) J. Clin. Oncol. , vol.33 , pp. TPS226
    • Doi, T.1    Kang, Y.K.2    Muro, K.3    Jiang, Y.4    Jain, R.K.5    Lizambri, R.6
  • 5
    • 33745077036 scopus 로고    scopus 로고
    • Updates on esophageal and gastric cancers
    • Gallo, A., Cha, C., Updates on esophageal and gastric cancers. World J. Gastroenterol.(12), 2006, 3237–3242.
    • (2006) World J. Gastroenterol. , Issue.12 , pp. 3237-3242
    • Gallo, A.1    Cha, C.2
  • 6
    • 0036097347 scopus 로고    scopus 로고
    • Gastric cancer – patterns of relapse after surgical resection
    • Gunderson, L.L., Gastric cancer – patterns of relapse after surgical resection. Semin. Radiat. Oncol. 12 (2002), 150–161.
    • (2002) Semin. Radiat. Oncol. , vol.12 , pp. 150-161
    • Gunderson, L.L.1
  • 7
    • 63849105841 scopus 로고    scopus 로고
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Updated March 2011]
    • The Cochrane Collaboration Available from
    • Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [Updated March 2011]. Higgins, J.P.T., Green, S., (eds.), 2011, The Cochrane Collaboration Available from www.cochrane-handbook.org.
    • (2011)
    • Higgins, J.P.T.1    Green, S.2
  • 8
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins, J.P., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses. BMJ 327:7414 (2003), 557–560.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 9
    • 84891372637 scopus 로고    scopus 로고
    • Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG trial
    • Epub 2013 November 4
    • Hironaka, S., Ueda, S., Yasui, H., Nishina, T., Tsuda, M., Tsumura, T., et al. Randomized, open-label, phase III study comparing irinotecan with paclitaxel in patients with advanced gastric cancer without severe peritoneal metastasis after failure of prior combination chemotherapy using fluoropyrimidine plus platinum: WJOG trial. J. Clin. Oncol. 31:December (35) (2013), 4438–4444, 10.1200/JCO.2012.48.5805 Epub 2013 November 4.
    • (2013) J. Clin. Oncol. , vol.31 , Issue.December (35) , pp. 4438-4444
    • Hironaka, S.1    Ueda, S.2    Yasui, H.3    Nishina, T.4    Tsuda, M.5    Tsumura, T.6
  • 10
    • 84862981823 scopus 로고    scopus 로고
    • Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone
    • Epub 2012 March 12
    • Kang, J.H., Lee, S.I., Lim do, H., Park, K.W., Oh, S.Y., Kwon, H.C., et al. Salvage chemotherapy for pretreated gastric cancer: a randomized phase III trial comparing chemotherapy plus best supportive care with best supportive care alone. Clin. Oncol. 30:May (13) (2012), 1513–1518, 10.1200/JCO.2011.39.4585 Epub 2012 March 12.
    • (2012) Clin. Oncol. , vol.30 , Issue.May (13) , pp. 1513-1518
    • Kang, J.H.1    Lee, S.I.2    Lim do, H.3    Park, K.W.4    Oh, S.Y.5    Kwon, H.C.6
  • 11
    • 84885961204 scopus 로고    scopus 로고
    • Irinotecan combined with 5-fluorouracil and leucovorin third-line chemotherapy after failure of fluoropyrimidine, platinum, and taxane in gastric cancer: treatment outcomes and a prognostic model to predict survival
    • Epub 2012 December 25
    • Kang, E.J., Im, S.A., Oh, D.Y., Han, S.W., Kim, J.S., Choi, I.S., et al. Irinotecan combined with 5-fluorouracil and leucovorin third-line chemotherapy after failure of fluoropyrimidine, platinum, and taxane in gastric cancer: treatment outcomes and a prognostic model to predict survival. Gastric Cancer 16:October (4) (2013), 581–589, 10.1007/s10120-012-0227-5 Epub 2012 December 25.
    • (2013) Gastric Cancer , vol.16 , Issue.October (4) , pp. 581-589
    • Kang, E.J.1    Im, S.A.2    Oh, D.Y.3    Han, S.W.4    Kim, J.S.5    Choi, I.S.6
  • 12
    • 85018495296 scopus 로고    scopus 로고
    • Nivolumab (ONO-4538/BMS-936558) as salvage treatment after second or later-line chemotherapy for advanced gastric or gastro-esophageal junction cancer (AGC): a double-blinded, randomized, phase III trial
    • Abstract 2
    • Kang, Y.K., Satoh, T., Ryu, M.H., et al. Nivolumab (ONO-4538/BMS-936558) as salvage treatment after second or later-line chemotherapy for advanced gastric or gastro-esophageal junction cancer (AGC): a double-blinded, randomized, phase III trial. J. Clin. Oncol., 35(Suppl), 2017, 4S Abstract 2.
    • (2017) J. Clin. Oncol. , vol.35 , pp. 4S
    • Kang, Y.K.1    Satoh, T.2    Ryu, M.H.3
  • 13
    • 36248985703 scopus 로고    scopus 로고
    • A phase II study of irinotecan with bi-weekly, low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFIRI) as salvage therapy for patients with advanced or metastatic gastric cancer
    • Epub 2007 October 8
    • Kim, S.G., Oh, S.Y., Kwon, H.C., Lee, S., Kim, J.H., Kim, S.H., et al. A phase II study of irinotecan with bi-weekly, low-dose leucovorin and bolus and continuous infusion 5-fluorouracil (modified FOLFIRI) as salvage therapy for patients with advanced or metastatic gastric cancer. Jpn. J. Clin. Oncol. 37:October (10) (2007), 744–749 Epub 2007 October 8.
    • (2007) Jpn. J. Clin. Oncol. , vol.37 , Issue.October (10) , pp. 744-749
    • Kim, S.G.1    Oh, S.Y.2    Kwon, H.C.3    Lee, S.4    Kim, J.H.5    Kim, S.H.6
  • 14
    • 84887116455 scopus 로고    scopus 로고
    • Second-line chemotherapy versus supportive cancer treatment in advanced gastric cancer: a meta-analysis
    • Epub 2013 August 13
    • Kim, H.S., Kim, H.J., Kim, S.Y., Kim, T.Y., Lee, K.W., Baek, S.K., et al. Second-line chemotherapy versus supportive cancer treatment in advanced gastric cancer: a meta-analysis. Ann. Oncol. 24:November (11) (2013), 2850–2854, 10.1093/annonc/mdt351 Epub 2013 August 13.
    • (2013) Ann. Oncol. , vol.24 , Issue.November (11) , pp. 2850-2854
    • Kim, H.S.1    Kim, H.J.2    Kim, S.Y.3    Kim, T.Y.4    Lee, K.W.5    Baek, S.K.6
  • 15
    • 84907486352 scopus 로고    scopus 로고
    • Chemotherapy or targeted therapy as second-line treatment of advanced gastric cancer. A systematic review and meta-analysis of published studies
    • eCollection, 2014
    • Lacovelli, R., Pietrantonio, F., Farcomeni, A., Maggi, C., Palazzo, A., Ricchini, F., et al. Chemotherapy or targeted therapy as second-line treatment of advanced gastric cancer. A systematic review and meta-analysis of published studies. PLOS ONE, 9(September (9)), 2014, e108940, 10.1371/journal.pone.0108940 eCollection 2014.
    • (2014) PLOS ONE , vol.9 , Issue.September (9) , pp. e108940
    • Lacovelli, R.1    Pietrantonio, F.2    Farcomeni, A.3    Maggi, C.4    Palazzo, A.5    Ricchini, F.6
  • 16
    • 38049103697 scopus 로고    scopus 로고
    • A phase II study of docetaxel as salvage chemotherapy in advanced gastric cancer after failure of fluoropyrimidine and platinum combination chemotherapy
    • Epub 2007 May 23
    • Lee, J.L., Ryu, M.H., Chang, H.M., Kim, T.W., Yook, J.H., Oh, S.T., et al. A phase II study of docetaxel as salvage chemotherapy in advanced gastric cancer after failure of fluoropyrimidine and platinum combination chemotherapy. Cancer Chemother. Pharmacol. 61:April (4) (2008), 631–637 Epub 2007 May 23.
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , Issue.April (4) , pp. 631-637
    • Lee, J.L.1    Ryu, M.H.2    Chang, H.M.3    Kim, T.W.4    Yook, J.H.5    Oh, S.T.6
  • 17
    • 84873972371 scopus 로고    scopus 로고
    • Outcomes of third-line docetaxel-based chemotherapy in advanced gastric cancer who failed previous oxaliplatin-based and irinotecan-based chemotherapies
    • Lee, M.J., Hwang, I.G., Jang, J.S., Choi, J.H., Park, B.B., Chang, M.H., et al. Outcomes of third-line docetaxel-based chemotherapy in advanced gastric cancer who failed previous oxaliplatin-based and irinotecan-based chemotherapies. Cancer Res. Treat. 44:December (4) (2012), 235–241.
    • (2012) Cancer Res. Treat. , vol.44 , Issue.December (4) , pp. 235-241
    • Lee, M.J.1    Hwang, I.G.2    Jang, J.S.3    Choi, J.H.4    Park, B.B.5    Chang, M.H.6
  • 18
    • 84878037244 scopus 로고    scopus 로고
    • Third-line docetaxel chemotherapy for recurrent and metastatic gastric cancer
    • Epub 2013 May 1
    • Lee, J.H., Kim, S.H., Oh, S.Y., Lee, S., Lee, H., Lee, H.J., et al. Third-line docetaxel chemotherapy for recurrent and metastatic gastric cancer. Korean J. Intern. Med. 28:May (3) (2013), 314–321, 10.3904/kjim.2013.28.3.314 Epub 2013 May 1.
    • (2013) Korean J. Intern. Med. , vol.28 , Issue.May (3) , pp. 314-321
    • Lee, J.H.1    Kim, S.H.2    Oh, S.Y.3    Lee, S.4    Lee, H.5    Lee, H.J.6
  • 19
    • 84891373220 scopus 로고    scopus 로고
    • Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial
    • Li, J., Qin, S., Xu, J., Guo, W., Xiong, J., Bai, Y., et al. Apatinib for chemotherapy-refractory advanced metastatic gastric cancer: results from a randomized, placebo-controlled, parallel-arm, phase II trial. J. Clin. Oncol. 31:26 (2013), 3219–3225.
    • (2013) J. Clin. Oncol. , vol.31 , Issue.26 , pp. 3219-3225
    • Li, J.1    Qin, S.2    Xu, J.3    Guo, W.4    Xiong, J.5    Bai, Y.6
  • 20
    • 84968894979 scopus 로고    scopus 로고
    • Randomized, double-blind, placebo-controlled phase III trial of apatinib in patients with chemotherapy-refractory advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction
    • Epub 2016 February 16
    • Li, J., Qin, S., Xu, J., Xiong, J., Wu, C., Bai, Y., et al. Randomized, double-blind, placebo-controlled phase III trial of apatinib in patients with chemotherapy-refractory advanced or metastatic adenocarcinoma of the stomach or gastroesophageal junction. J. Clin. Oncol. 34:May (13) (2016), 1448–1454, 10.1200/JCO.2015.63.5995 Epub 2016 February 16.
    • (2016) J. Clin. Oncol. , vol.34 , Issue.May (13) , pp. 1448-1454
    • Li, J.1    Qin, S.2    Xu, J.3    Xiong, J.4    Wu, C.5    Bai, Y.6
  • 21
    • 85024872992 scopus 로고    scopus 로고
    • Systematic review and meta-analysis of recommended second-line therapies for advanced gastric cancer (GC)
    • Conference: European Cancer Congress 2015, ECC 2015 Vienna Austria. Conference Start: 20150925 Conference End: 20150929. Conference Publication: (var.pagings). 51 (pp S437), 2015. Date of Publication: September, 2015
    • Liepa, A., Mitchell, S., Batson, S., Jen, M.H., Davie, A., Taipale, K., Hess, L., Systematic review and meta-analysis of recommended second-line therapies for advanced gastric cancer (GC). Eur. J. Cancer, 2015 Conference: European Cancer Congress 2015, ECC 2015 Vienna Austria. Conference Start: 20150925 Conference End: 20150929. Conference Publication: (var.pagings). 51 (pp S437), 2015. Date of Publication: September 2015.
    • (2015) Eur. J. Cancer
    • Liepa, A.1    Mitchell, S.2    Batson, S.3    Jen, M.H.4    Davie, A.5    Taipale, K.6    Hess, L.7
  • 22
    • 78149316175 scopus 로고    scopus 로고
    • Outcomes of multiple salvage chemotherapy for advanced gastric cancer: implications for clinical practice and trial design
    • Epub 2010 March 11
    • Moon, Y.W., Rha, S.Y., Jeung, H.C., Kim, C., Hong, M.H., Chang, H., et al. Outcomes of multiple salvage chemotherapy for advanced gastric cancer: implications for clinical practice and trial design. Cancer Chemother. Pharmacol. 66:September (4) (2010), 797–805, 10.1007/s00280-010-1295-z Epub 2010 March 11.
    • (2010) Cancer Chemother. Pharmacol. , vol.66 , Issue.September (4) , pp. 797-805
    • Moon, Y.W.1    Rha, S.Y.2    Jeung, H.C.3    Kim, C.4    Hong, M.H.5    Chang, H.6
  • 23
    • 85024890892 scopus 로고    scopus 로고
    • NCT02494583: Study of
    • Available from:
    • NCT02494583: Study of. 2015 Available from: https://clinicaltrials.gov/ct2/show/NCT02494583?term=keynote-062&rank=1.
    • (2015)
  • 24
    • 85024855982 scopus 로고    scopus 로고
    • NCT02625610: Avelumab in
    • Available from:
    • NCT02625610: Avelumab in. 2015 Available from: https://clinicaltrials.gov/ct2/show/NCT02625610?term=JAVELIN+Gastric+100&rank=1.
    • (2015)
  • 25
    • 85024875756 scopus 로고    scopus 로고
    • NCT02625623: Avelumab in
    • Available from:
    • NCT02625623: Avelumab in. 2015 Available from: https://clinicaltrials.gov/ct2/show/NCT02625623?term=JAVELIN+Gastric+100&rank=2.
    • (2015)
  • 26
    • 85024880438 scopus 로고    scopus 로고
    • NCT02773524: A
    • Available from:
    • NCT02773524: A. 2016 Available from: https://clinicaltrials.gov/ct2/show/NCT02773524?term=integrateII&rank=1.
    • (2016)
  • 27
    • 85024889715 scopus 로고    scopus 로고
    • NCT02370498: A
    • Available from:
    • NCT02370498: A. 2016 Available from: http://www.clinicaltrials.gov/ct/show/NCT02370498.
    • (2016)
  • 28
    • 84891371392 scopus 로고    scopus 로고
    • Everolimus for previously treated advanced gastric cancer: results of the randomized double-blind phase III GRANITE-1 study
    • Epub 2013 September 16
    • Ohtsu, A., Ajani, J.A., Bai, Y.X., Bang, Y.J., Chung, H.C., Pan, H.M., et al. Everolimus for previously treated advanced gastric cancer: results of the randomized double-blind phase III GRANITE-1 study. J. Clin. Oncol. 31:November (31) (2013), 3935–3943, 10.1200/JCO.2012.48.3552 Epub 2013 September 16.
    • (2013) J. Clin. Oncol. , vol.31 , Issue.November (31) , pp. 3935-3943
    • Ohtsu, A.1    Ajani, J.A.2    Bai, Y.X.3    Bang, Y.J.4    Chung, H.C.5    Pan, H.M.6
  • 29
    • 20944436198 scopus 로고    scopus 로고
    • Salvage chemotherapy with irinotecan and cisplatin in patients with metastatic gastric cancer failing both 5-fluorouracil and taxanes
    • Park, S.H., Choi, E.Y., Bang, S.M., Cho, E.K., Lee, J.H., Shin, D.B., et al. Salvage chemotherapy with irinotecan and cisplatin in patients with metastatic gastric cancer failing both 5-fluorouracil and taxanes. Anticancer Drugs 16:July (6) (2005), 621–625.
    • (2005) Anticancer Drugs , vol.16 , Issue.July (6) , pp. 621-625
    • Park, S.H.1    Choi, E.Y.2    Bang, S.M.3    Cho, E.K.4    Lee, J.H.5    Shin, D.B.6
  • 30
    • 84951568141 scopus 로고    scopus 로고
    • INTEGRATE: a randomized, phase II, double-blind, placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC): a study by the Australasian Gastrointestinal Trials Group (AGITG)-final overall and subgroup results
    • Conference: 2015 Annual Meeting of the American Society of Clinical Oncology, ASCO Chicago, IL United States. Conference Start: 20150529 Conference End: 20150602. Conference Publication: (var.pagings). 33 (15 SUPPL. 1) (no pagination), 2015. Date of Publication: 20 May, 2015
    • Pavlakis, N., Sjoquist, K.M., Tsobanis, E., Martin, A.J., Kang, Y.-K., Bang, J., et al. INTEGRATE: a randomized, phase II, double-blind, placebo-controlled study of regorafenib in refractory advanced oesophagogastric cancer (AOGC): a study by the Australasian Gastrointestinal Trials Group (AGITG)-final overall and subgroup results. J. Clin. Oncol., 2015 Conference: 2015 Annual Meeting of the American Society of Clinical Oncology, ASCO Chicago, IL United States. Conference Start: 20150529 Conference End: 20150602. Conference Publication: (var.pagings). 33 (15 SUPPL. 1) (no pagination), 2015. Date of Publication: 20 May 2015.
    • (2015) J. Clin. Oncol.
    • Pavlakis, N.1    Sjoquist, K.M.2    Tsobanis, E.3    Martin, A.J.4    Kang, Y.-K.5    Bang, J.6
  • 31
    • 53249086693 scopus 로고    scopus 로고
    • EORTC Quality of Life Group. EORTC QLQ-C30 Reference Values
    • EORTC Quality of Life Group Publications Brussels Available from
    • Scott, N.W., Fayers, P.M., Aaronson, N.K., Bottomley, A., de Graeff, A., Groenvold, M., et al. EORTC Quality of Life Group. EORTC QLQ-C30 Reference Values. 2008, EORTC Quality of Life Group Publications, Brussels Available from http://groups.eortc.be/qol/sites/default/files/img/newsletter/reference_values_manual2008.pdf.
    • (2008)
    • Scott, N.W.1    Fayers, P.M.2    Aaronson, N.K.3    Bottomley, A.4    de Graeff, A.5    Groenvold, M.6
  • 32
    • 84940608924 scopus 로고    scopus 로고
    • METGastric: a phase III study of onartuzumab plus mFOLFOX6 in patients with metastatic HER2-negative (HER2−) and MET-positive (MET+) adenocarcinoma of the stomach or gastroesophageal junction (GEC)
    • Shah, M.A., Bang, Y.J., Lordick, F., Tabernero, J., Chen, M., Hack, S.P., Phan, S.C., Shames, D.S., Cunningham, D., METGastric: a phase III study of onartuzumab plus mFOLFOX6 in patients with metastatic HER2-negative (HER2−) and MET-positive (MET+) adenocarcinoma of the stomach or gastroesophageal junction (GEC). J. Clin. Oncol., 33(Suppl. 15), 2015, 4012.
    • (2015) J. Clin. Oncol. , vol.33 , pp. 4012
    • Shah, M.A.1    Bang, Y.J.2    Lordick, F.3    Tabernero, J.4    Chen, M.5    Hack, S.P.6    Phan, S.C.7    Shames, D.S.8    Cunningham, D.9
  • 33
    • 77949900399 scopus 로고    scopus 로고
    • Weekly paclitaxel for heavily treated advanced or recurrent gastric cancer refractory to fluorouracil, irinotecan, and cisplatin
    • Epub 2010 January 5
    • Shimoyama, R., Yasui, H., Boku, N., Onozawa, Y., Hironaka, S., Fukutomi, A., et al. Weekly paclitaxel for heavily treated advanced or recurrent gastric cancer refractory to fluorouracil, irinotecan, and cisplatin. Gastric Cancer 12:4 (2009), 206–211, 10.1007/s10120-009-0524-9 Epub 2010 January 5.
    • (2009) Gastric Cancer , vol.12 , Issue.4 , pp. 206-211
    • Shimoyama, R.1    Yasui, H.2    Boku, N.3    Onozawa, Y.4    Hironaka, S.5    Fukutomi, A.6
  • 34
    • 84958039700 scopus 로고    scopus 로고
    • Efficacy and toxicity of salvage weekly paclitaxel chemotherapy in non-Asian patients with advanced oesophagogastric adenocarcinoma
    • Tarazona, N., Smyth, E.C., Peckit, C., Chau, I., Watkins, D., Rao, S., et al. Efficacy and toxicity of salvage weekly paclitaxel chemotherapy in non-Asian patients with advanced oesophagogastric adenocarcinoma. Ther. Adv. Med. Oncol. 8:March (2) (2016), 104–112, 10.1177/1758834015621669.
    • (2016) Ther. Adv. Med. Oncol. , vol.8 , Issue.March (2) , pp. 104-112
    • Tarazona, N.1    Smyth, E.C.2    Peckit, C.3    Chau, I.4    Watkins, D.5    Rao, S.6
  • 35
    • 84943197579 scopus 로고    scopus 로고
    • Review Manager (RevMan). 5.3
    • The Nordic Cochrane Centre, The Cochrane Collaboration Copenhagen
    • The Nordic Cochrane Centre, The Cochrane Collaboration, Review Manager (RevMan). 5.3. 2014, The Nordic Cochrane Centre, The Cochrane Collaboration, Copenhagen.
    • (2014)
    • The Nordic Cochrane Centre, The Cochrane Collaboration,1
  • 38
    • 84908139963 scopus 로고    scopus 로고
    • Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial
    • Epub 2014 September 17
    • Wilke, H., Muro, K., Van Cutsem, E., Oh, S.C., Bodoky, G., Shimada, Y., et al. Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial. Lancet Oncol. 15:October (11) (2014), 1224–1235, 10.1016/S1470-2045(14)70420-6 Epub 2014 September 17.
    • (2014) Lancet Oncol. , vol.15 , Issue.October (11) , pp. 1224-1235
    • Wilke, H.1    Muro, K.2    Van Cutsem, E.3    Oh, S.C.4    Bodoky, G.5    Shimada, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.