How to design efficient cluster randomised trials

BMJ (Online)

Volumn 358, Issue , 2017, Pages

  Hemming, K ^a   Eldridge, S ^b   Forbes, G ^b   Weijer, C ^c   Taljaard, M ^d,e  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^c WESTERN UNIVERSITY   (Canada)

^d OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^e UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ANTIBIOTIC PROPHYLAXIS; ARTICLE; CASE STUDY; CLUSTER ANALYSIS; CORRELATION COEFFICIENT; DIAGNOSTIC EQUIPMENT; FUNDING; GROUP B STREPTOCOCCAL INFECTION; HUMAN; METHODOLOGY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; RISK REDUCTION; STREPTOCOCCUS GROUP B RAPID TEST; STUDY DESIGN; HEALTH SERVICES RESEARCH; PRACTICE GUIDELINE; PROCEDURES; SAMPLE SIZE; TREATMENT OUTCOME;

CLUSTER ANALYSIS; GUIDELINES AS TOPIC; HEALTH SERVICES RESEARCH; HUMANS; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH DESIGN; SAMPLE SIZE;

EID: 85024489322     PISSN: 09598146     EISSN: 17561833     Source Type: Journal    
DOI: 10.1136/bmj.j3064     Document Type: Article

References (16)

1. Eldridge S, Kerry S. Introduction. In: A practical guide to cluster randomised trials in health services research.John Wiley and Sons, 2012. doi:10.1002/9781119966241.ch1
2. Angus DC. Fusing randomized trials with big data: the key to self-learning health care systems JAMA 2015;314:767-8. doi:10.1001/jama.2015.7762
3. Peto R, Collins R, Gray R. Large-scale randomized evidence: large, simple trials and overviews of trials. J Clin Epidemiol 1995;48:23-40. doi:10.1016/0895-4356(94)00150-O
4. Donner A. Some aspects of the design and analysis of cluster randomization trials. J R Stat Soc Ser C Appl Stat 1998;47:95-113. doi:10.1111/1467-9876.00100
5. Donner A, Klar N. Statistical considerations in the design and analysis of community intervention trials. J Clin Epidemiol 1996;49:435-9. doi:10.1016/0895-4356(95)00511-0
6. Guittet L, Giraudeau B, Ravaud P. A priori postulated and real power in cluster randomized trials: mind the gap. BMC Med Res Methodol 2005;5:25. doi:10.1186/1471-2288-5-25
7. Hemming K, Girling AJ, Sitch AJ, Marsh J, Lilford RJ. Sample size calculations for cluster randomised controlled trials with a fixed number of clusters. BMC Med Res Methodol 2011;11:102. doi:10.1186/1471-2288-11-102
8. Campbell MJ, Donner A, Klar N. Developments in cluster randomized trials and statistics in medicine. Stat Med 2007;26:2-19. doi:10.1002/sim.2731
9. Campbell M, Walters SJ. How to design, analyse and report cluster randomised trials in medicine and health related research. Statistics in Practice Wiley, 2014. doi:10.1002/9781118763452
10. Carter B. Cluster size variability and imbalance in cluster randomized controlled trials. Stat Med 2010;29:2984-93. doi:10.1002/sim.4050
11. Woolston C. Psychology journal bans P values. Nature 2015;519:9-10. doi:10.1038/519009f
12. Bland JM. The tyranny of power: is there a better way to calculate sample size BMJ 2009;339:b3985. doi:10.1136/bmj.b3985
13. Eldridge SM, Costelloe CE, Kahan BC, Lancaster GA, Kerry SM. How big should the pilot study for my cluster randomised trial be Stat Methods Med Res 2016;25:1039-56. doi:10.1177/0962280215588242
14. Campbell MK, Mollison J, Grimshaw JM. Cluster trials in implementation research: estimation of intracluster correlation coefficients and sample size. Stat Med 2001;20:391-9. doi:10.1002/1097-0258(20010215)20:3<391::AID-SIM800>3.0.CO;2-Z
15. Taljaard M, Teerenstra S, Ivers NM, Fergusson DA. Substantial risks associated with few clusters in cluster randomized and stepped wedge designs. Clin Trials 2016;13:459-63. doi:10.1177/1740774516634316
16. Hooper R, Bourke L. Cluster randomised trials with repeated cross sections: alternatives to parallel group designs. BMJ 2015;350:h2925. doi:10.1136/bmj.h2925