Global outbreak of severe Mycobacterium chimaera disease after cardiac surgery: a molecular epidemiological study

The Lancet Infectious Diseases

Volumn 17, Issue 10, 2017, Pages 1033-1041

  van Ingen, Jakko ^a   Kohl, Thomas A ^b,c   Kranzer, Katharina ^b   Hasse, Barbara ^d   Keller, Peter M ^e   Katarzyna Szafrańska, Anna ^f,g   Hillemann, Doris ^b   Chand, Meera ^h,i,j   Schreiber, Peter Werner ^d   Sommerstein, Rami ^d,k   Berger, Christoph ^l   Genoni, Michele ^m   Rüegg, Christian ^d   Troillet, Nicolas ⁿ   Widmer, Andreas F ^o   Becker, Sören L ^p,q   Herrmann, Mathias ^p   Eckmanns, Tim ^r   Haller, Sebastian ^r   Höller, Christiane ^s   Debast, Sylvia B ^t   Wolfhagen, Maurice J ^t   Hopman, Joost ^a   Kluytmans, Jan ^u,v   Langelaar, Merel ^w   Notermans, Daan W ^x   ten Oever, Jaap ^a   van den Barselaar, Peter ^y   Vonk, Alexander B A ^z   Vos, Margreet C ^aa   Ahmed, Nada ^h   Brown, Timothy ^h   Crook, Derrick ^h,ab   Lamagni, Theresa ^h   Phin, Nick ^h   Smith, E Grace ^h,ac   Zambon, Maria ^h   Serr, Annerose ^ad   Götting, Tim ^ae   Ebner, Winfried ^ae   Thürmer, Alexander ^af   Utpatel, Christian ^b,c   Spröer, Cathrin ^f,g   Bunk, Boyke ^f,g   Nübel, Ulrich ^f,g   Bloemberg, Guido V ^e   Böttger, Erik C ^e   Niemann, Stefan ^b,c   Wagner, Dirk ^ae   Sax, Hugo ^d   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b RESEARCH CENTER BORSTEL   (Germany)

^c German Center for Infection Research   (Germany)

^d UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^e UNIVERSITY OF ZURICH   (Switzerland)

^f LEIBNIZ INSTITUTE DSMZ GERMAN COLLECTION OF MICROORGANISMS AND CELL CULTURES   (Germany)

^g HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^h PUBLIC HEALTH ENGLAND   (United Kingdom)

ⁱ GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^j IMPERIAL COLLEGE LONDON   (United Kingdom)

^k UNIVERSITY OF BERN   (Switzerland)

^l UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^m TRIEMLI HOSPITAL   (Switzerland)

ⁿ Valais Hospitals   (Switzerland)

^o UNIVERSITY OF BASEL   (Switzerland)

^p SAARLAND UNIVERSITY   (Germany)

^q SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^r ROBERT KOCH INSTITUTE   (Germany)

^s Bavarian Health and Food Safety Authority   (Germany)

^t Laboratory for Medical Microbiology and Infectious Diseases   (Netherlands)

^u AMPHIA HOSPITAL   (Netherlands)

^v UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^w Healthcare Inspectorate   (Netherlands)

^x NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^y ST ANTONIUS HOSPITAL   (Netherlands)

^z VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^aa ERASMUS MEDICAL CENTER   (Netherlands)

^ab UNIVERSITY OF OXFORD   (United Kingdom)

^ac HPA Birmingham Public Health Laboratory   (United Kingdom)

^ad UNIVERSITY OF FREIBURG   (Germany)

^ae UNIVERSITY OF FREIBURG   (Germany)

^af DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIUM ISOLATE; CLINICAL ARTICLE; CLONAL VARIATION; GENE FREQUENCY; GENETIC ASSOCIATION; GENOMIC ISLAND; GERMANY; HEART SURGERY; HUMAN; MYCOBACTERIOSIS; MYCOBACTERIUM CHIMAERA INFECTION; MYCOBACTERIUM INTRACELLULARE; NETHERLANDS; NEXT GENERATION SEQUENCING; NONHUMAN; PATIENT SAFETY; PHYLOGENETIC TREE; PHYLOGENY; POSTOPERATIVE INFECTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SWITZERLAND; THORAX SURGERY; TRANSPOSON; UNITED KINGDOM; UNITED STATES; WHOLE GENOME SEQUENCING; ADVERSE EFFECTS; GENETICS; GLOBAL HEALTH; HEART VALVE PROSTHESIS; IATROGENIC DISEASE; ISOLATION AND PURIFICATION; MEDICAL DEVICE CONTAMINATION; MICROBIOLOGY; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; PROSTHESIS-RELATED INFECTIONS;

CARDIAC SURGICAL PROCEDURES; EQUIPMENT CONTAMINATION; GLOBAL HEALTH; HEART VALVE PROSTHESIS; HUMANS; IATROGENIC DISEASE; MYCOBACTERIUM; MYCOBACTERIUM INFECTIONS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTHESIS-RELATED INFECTIONS;

EID: 85023763788     PISSN: 14733099     EISSN: 14744457     Source Type: Journal    
DOI: 10.1016/S1473-3099(17)30324-9     Document Type: Article

References (21)

1. Achermann, Y, Rössle, M, Hoffmann, M, et al. Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera. J Clin Microbiol 51 (2013), 1769–1773.
2. Kohler, P, Kuster, SP, Bloemberg, G, et al. Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery. Eur Heart J 36 (2015), 2745–2753.
3. Public Health England. Mycobacterium chimaera: infections linked to heater cooler units. https://www.gov.uk/government/news/mycobacterial-infections-associated-with-cardiopulmonary-bypass-surgery, May 31, 2017 (accessed June 29, 2017).
4. Götting, T, Klassen, S, Jonas, D, et al. Heater–cooler units: contamination of crucial devices in cardiothoracic surgery. J Hosp Infect 93 (2016), 223–228.
5. Perkins, KM, Lawsin, A, Hasan, NA, et al. Notes from the field: Mycobacterium chimaera contamination of heater–cooler devices used in cardiac surgery—United States. MMWR Morb Mortal Wkly Rep 65 (2016), 1117–1118.
6. Tan, N, Sampath, R, Abu Saleh, OM, et al. Disseminated Mycobacterium chimaera infection after cardiothoracic surgery. Open Forum Infect Dis, 3, 2016, ofw131.
7. Williamson, D, Howden, B, Stinear, T, Mycobacterium chimaera spread from heating and cooling units in heart surgery. N Engl J Med 376 (2017), 600–602.
8. Griffith, DE, Aksamit, T, Brown-Elliott, BA, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 175 (2007), 367–416.
9. Weitkemper, HH, Spilker, A, Knobl, HJ, Körfer, R, The heater–cooler unit—a conceivable source of infection. J Extra Corpor Technol 34 (2002), 276–280.
10. Sommerstein, R, Rüegg, C, Kohler, P, Bloemberg, G, Kuster, SP, Sax, H, Transmission of Mycobacterium chimaera from heater–cooler units during cardiac surgery despite an ultraclean air ventilation system. Emerg Infect Dis 22 (2016), 1008–1013.
11. Köser, CU, Ellington, MJ, Cartwright, EJ, et al. Routine use of microbial whole genome sequencing in diagnostic and public health microbiology. PLoS Pathog, 8, 2012, e1002824.
12. Tortoli, E, Rindi, L, Garcia, MJ, et al. Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov. Int J Syst Evol Microbiol 54 (2004), 1277–1285.
13. European Centre for Disease Prevention and Control. EU protocol for case detection, laboratory diagnosis and environmental testing of Mycobacterium chimaera infections potentially associated with heater-cooler units: case definition and environmental testing methodology. http://ecdc.europa.eu/en/publications/Publications/EU-protocol-for-M-chimaera.pdf (accessed April 4, 2017).
14. Blom, J, Jakobi, T, Doppmeier, D, et al. Exact and complete short-read alignment to microbial genomes using Graphics Processing Unit programming. Bioinformatics 27 (2011), 1351–1358.
15. Mac Aogáin, M, Roycroft, E, Raftery, P, Mok, S, Fitzgibbon, M, Rogers, TR, Draft genome sequences of three Mycobacterium chimaera respiratory isolates. Genome Announc 3 (2015), e01409–e01415.
16. Svensson, E, Jensen, ET, Rasmussen, EM, Folkvardsen, DB, Norman, A, Lillebaek, T, Mycobacterium chimaera in heater–cooler units in Denmark related to isolates from the United States and United Kingdom. Emerg Infect Dis 23 (2017), 507–509.
17. Alikhan, NF, Petty, NK, Ben Zakour, NL, Beatson, SA, BLAST Ring Image Generator (BRIG): simple prokaryote genome comparisons. BMC Genomics, 12, 2011, 402.
18. Roetzer, A, Diel, R, Kohl, TA, et al. Whole genome sequencing versus traditional genotyping for investigation of a Mycobacterium tuberculosis outbreak: a longitudinal molecular epidemiological study. PLoS Med, 10, 2013, e1001387.
19. Bryant, JM, Grogono, DM, Greaves, D, et al. Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study. Lancet 381 (2013), 1551–1560.
20. Vuković, D, Parezanović, V, Savić, B, et al. Mycobacterium fortuitum endocarditis associated with cardiac surgery, Serbia. Emerg Infect Dis 19 (2013), 517–519.
21. Stucki, D, Brites, D, Jeljeli, L, et al. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages. Nat Genet 48 (2016), 1535–1543.