The effect of variation in donor platelet function on transfusion outcome: A semirandomized controlled trial

Blood

Volumn 130, Issue 2, 2017, Pages 214-220

  Kelly, Anne M ^a   Garner, Stephen F ^a,b   Foukaneli, Theodora ^b   Godec, Thomas R ^c   Herbert, Nina ^a   Kahan, Brennan C ^d   Deary, Alison ^b   Bakrania, Lekha ^b   Llewelyn, Charlotte ^b   Ouwehand, Willem H ^a,b   Williamson, Lorna M ^a,b   Cardigan, Rebecca A ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c MEDICAL RESEARCH COUNCIL   (United Kingdom)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LEUKEMIA; ADULT; ARTICLE; BONE MARROW DEPRESSION; COHORT ANALYSIS; CONTROLLED STUDY; DONOR; DOUBLE BLIND PROCEDURE; FEMALE; FLOW CYTOMETRY; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; PARALLEL DESIGN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; TREATMENT OUTCOME; UNITED KINGDOM; AGED; APLASTIC ANEMIA; BLOOD; BLOOD CLOTTING PARAMETERS; BONE MARROW DISEASE; CLASSIFICATION; COMPLICATION; CYTOLOGY; DRUG EFFECTS; HEMORRHAGE; INTENTION TO TREAT ANALYSIS; MIDDLE AGED; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; PATHOLOGY; PHYSIOLOGY; THROMBOCYTE; THROMBOCYTE ACTIVATION;

THROMBOCYTE ACTIVATING FACTOR;

ADULT; AGED; ANEMIA, APLASTIC; BLOOD PLATELETS; BONE MARROW DISEASES; DOUBLE-BLIND METHOD; FEMALE; HEMOGLOBINURIA, PAROXYSMAL; HEMORRHAGE; HUMANS; INTENTION TO TREAT ANALYSIS; MALE; MIDDLE AGED; PLATELET ACTIVATING FACTOR; PLATELET ACTIVATION; PLATELET COUNT; PLATELET FUNCTION TESTS; PLATELET TRANSFUSION; THROMBOCYTOPENIA; TISSUE DONORS;

EID: 85023761666     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2017-01-759258     Document Type: Article

References (25)

1. Estcourt LJ, Stanworth SJ, Murphy MF. Platelet transfusions for patients with haematological malignancies: who needs them? Br J Haematol. 2011;154(4):425-440.
2. Fontana P, Dupont A, Gandrille S, et al. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation. 2003;108(8):989-995.
3. Gaxiola B, Friedl W, Propping P. Epinephrine-induced platelet aggregation. A twin study. Clin Genet. 1984;26(6):543-548.
4. Jones CI, Garner SF, Angenent W, et al; Bloodomics Consortium. Mapping the platelet profile for functional genomic studies and demonstration of the effect size of the GP6 locus. J Thromb Haemost. 2007;5(8):1756-1765.
5. Garner SF, Furnell A, Kahan BC, et al. Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time. Vox Sang. 2017;112(1):18-24.
6. Garner SF, Jones CI, Stephens J, et al; BLOODOMICS Consortium. Apheresis donors and platelet function: inherent platelet responsiveness influences platelet quality. Transfusion. 2008;48(4):673-680.
7. Leytin V, Allen DJ, Gwozdz A, Garvey B, Freedman J. Role of platelet surface glycoprotein Ibalpha and P-selectin in the clearance of transfused platelet concentrates. Transfusion. 2004;44(10):1487-1495.
8. Berger G, Hartwell DW, Wagner DD. P-Selectin and platelet clearance. Blood. 1998;92(11): 4446-4452.
9. Michelson AD, Barnard MR, Hechtman HB, et al. In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function. Proc Natl Acad Sci USA. 1996;93(21): 11877-11882.
10. Rinder HM, Murphy M, Mitchell JG, Stocks J, Ault KA, Hillman RS. Progressive platelet activation with storage: evidence for shortened survival of activated platelets after transfusion. Transfusion. 1991;31(5):409-414.
11. Dumont LJ, AuBuchon JP, Whitley P, et al. Seven-day storage of single-donor platelets: recovery and survival in an autologous transfusion study. Transfusion. 2002;42(7):847-854.
12. Slichter SJ, Bolgiano D, Corson J, Jones MK, Christoffel T, Pellham E. Extended storage of autologous apheresis platelets in plasma. Vox Sang. 2013;104(4):324-330.
13. Van’t Erve TJ, Wagner BA, Martin SM, et al. The heritability of hemolysis in stored human red blood cells. Transfusion. 2015;55(6):1178-1185.
14. Schubert P, Culibrk B, Karwal S, Slichter SJ, Devine DV. Optimization of platelet concentrate quality: application of proteomic technologies to donor management. J Proteomics. 2012;76: 329-336.
15. Waterman HR, Kapp LM, Howie HL, Hod EA, Spitalnik SL, Zimring JC. Analysis of 24-h recovery of transfused stored RBCs in recipient mice of distinct genetic backgrounds. Vox Sang. 2015;109(2):148-154.
16. NHS Blood and Transplant. PROmPT (Platelet Responsiveness and Outcome from Platelet Transfusion). Does inherent variation in donor platelet function affect the clinical efficacy of apheresis platelets? A randomised double blind single centre trial. http://www.nhsbt.nhs.uk/download/prompt_trial_protocol.pdf. Accessed 20 November 2016.
17. National Blood Service. Guidelines for the Blood Transfusion Services in the United Kingdom. London, United Kingdom: The Stationary Office; 2013.
18. Stanworth SJ, Dyer C, Casbard A, Murphy MF. Feasibility and usefulness of self-assessment of bleeding in patients with haematological malignancies, and the association between platelet count and bleeding. Vox Sang. 2006; 91(1):63-69.
19. Stanworth SJ, Estcourt LJ, Powter G, et al; TOPPS Investigators. A no-prophylaxis platelet-transfusion strategy for hematologic cancers. N Engl J Med. 2013;368(19):1771-1780.
20. MacLennan S, Harding K, Llewelyn C, et al. A randomized noninferiority crossover trial of corrected count increments and bleeding in thrombocytopenic hematology patients receiving 2- to 5- versus 6- or 7-day-stored platelets. Transfusion. 2015;55(8):1856-1865.
21. NHS Blood and Transplant. PROmPT (Platelet Responsiveness and Outcome from Platelet Transfusion). Statistical analysis plan. http://www.nhsbt.nhs.uk/download/PROMPT_SAP.pdf. Accessed November 20, 2016.
22. Triulzi DJ, Kickler TS, Braine HG. Detection and significance of alpha granule membrane protein 140 expression on platelets collected by apheresis. Transfusion. 1992;32(6):529-533.
23. Parco S, Vascotto F. Application of reticulated platelets to transfusion management during autologous stem cell transplantation. Onco Targets Ther. 2012;5:1-5.
24. Briggs C, Hart D, Kunka S, Oguni S, Machin SJ. Immature platelet fraction measurement: a future guide to platelet transfusion requirement after haematopoietic stem cell transplantation. Transfus Med. 2006;16(2):101-109.
25. Butler C, Doree C, Estcourt LJ, et al. Pathogen-reduced platelets for the prevention of bleeding. Cochrane Database Syst Rev. 2013;3:CD009072.