-
1
-
-
85023170530
-
-
Pfizer, distributed by G.D. Searle LLC, LAB-0231-4.0, revised January 2008. New York, NY, USA: Pfizer Inc
-
Aldactone NDA. 2008. Aldactone, spironolactone tablets USP, NDA 12-151/S-062, Pfizer, distributed by G.D. Searle LLC, LAB-0231-4.0, revised January 2008. New York, NY, USA: Pfizer Inc. (available at: http://www. accessdata.fda.gov/drugsatfda_docs/label/2008/012151s062lbl.pdf)
-
(2008)
Aldactone, spironolactone tablets USP, NDA 12-151/S-062
-
-
Aldactone, N.D.A.1
-
2
-
-
84941337023
-
Finerenone impedes aldosterone-dependent nuclear import of the mineralocorticoid receptor and prevents genomic recruitment of steroid receptor coactivator-1
-
Amazit L, Le Billan F, Kolkhof P, Lamribet K, Viengchareun S, Fay MR, Khan JA, Hillisch A, Lombès M, Rafestin-Oblin ME, et al. 2015. Finerenone impedes aldosterone-dependent nuclear import of the mineralocorticoid receptor and prevents genomic recruitment of steroid receptor coactivator-1. Journal of Biological Chemistry 290:21876-21889. (doi:10.1074/jbc.M115.657957)
-
(2015)
Journal of Biological Chemistry
, vol.290
, pp. 21876-21889
-
-
Amazit, L.1
Le Billan, F.2
Kolkhof, P.3
Lamribet, K.4
Viengchareun, S.5
Fay, M.R.6
Khan, J.A.7
Hillisch, A.8
Lombès, M.9
Rafestin-Oblin, M.E.10
-
3
-
-
84935872611
-
Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist
-
Arai K, Homma T, Morikawa Y, Ubukata N, Tsuruoka H, Aoki K, Ishikawa H, Mizuno M & Sada T. 2015. Pharmacological profile of CS-3150, a novel, highly potent and selective non-steroidal mineralocorticoid receptor antagonist. European Journal of Pharmacology 761:226-234. (doi:10.1016/j.ejphar.2015.06.015)
-
(2015)
European Journal of Pharmacology
, vol.761
, pp. 226-234
-
-
Arai, K.1
Homma, T.2
Morikawa, Y.3
Ubukata, N.4
Tsuruoka, H.5
Aoki, K.6
Ishikawa, H.7
Mizuno, M.8
Sada, T.9
-
4
-
-
84948951465
-
CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist, prevents hypertension and cardiorenal injury in Dahl salt-sensitive hypertensive rats
-
Arai K, Tsuruoka H & Homma T. 2015. CS-3150, a novel non-steroidal mineralocorticoid receptor antagonist, prevents hypertension and cardiorenal injury in Dahl salt-sensitive hypertensive rats. European Journal of Pharmacology 769:266-273. (doi:10.1016/j.ejphar.2015.11.028)
-
(2015)
European Journal of Pharmacology
, vol.769
, pp. 266-273
-
-
Arai, K.1
Tsuruoka, H.2
Homma, T.3
-
5
-
-
84983742558
-
CS-3150, a novel nonsteroidal mineralocorticoid receptor antagonist, shows preventive and therapeutic effects on renal injury in deoxycorticosterone acetate/salt-induced hypertensive rats
-
Arai K, Morikawa Y, Ubukata N, Tsuruoka H & Homma T. 2016. CS-3150, a novel nonsteroidal mineralocorticoid receptor antagonist, shows preventive and therapeutic effects on renal injury in deoxycorticosterone acetate/salt-induced hypertensive rats. Journal of Pharmacology and Experimental Therapeutics 358:548-557. (doi:10.1124/jpet.116.234765)
-
(2016)
Journal of Pharmacology and Experimental Therapeutics
, vol.358
, pp. 548-557
-
-
Arai, K.1
Morikawa, Y.2
Ubukata, N.3
Tsuruoka, H.4
Homma, T.5
-
6
-
-
77955907538
-
Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists
-
Arhancet GB, Woodard SS, Iyanar K, Case BL, Woerndle R, Dietz JD, Garland DJ, Collins JT, Payne MA, Blinn JR, et al. 2010. Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists. Journal of Medicinal Chemistry 53:5970-5978. (doi:10.1021/jm100506y)
-
(2010)
Journal of Medicinal Chemistry
, vol.53
, pp. 5970-5978
-
-
Arhancet, G.B.1
Woodard, S.S.2
Iyanar, K.3
Case, B.L.4
Woerndle, R.5
Dietz, J.D.6
Garland, D.J.7
Collins, J.T.8
Payne, M.A.9
Blinn, J.R.10
-
7
-
-
0023221667
-
Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor
-
Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE & Evans RM. 1987. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science 237:268-275. (doi:10.1126/science.3037703)
-
(1987)
Science
, vol.237
, pp. 268-275
-
-
Arriza, J.L.1
Weinberger, C.2
Cerelli, G.3
Glaser, T.M.4
Handelin, B.L.5
Housman, D.E.6
Evans, R.M.7
-
8
-
-
84940729269
-
Effect of finerenone on albuminuria in patients with diabetic nephropathy: a randomized clinical trial. Mineralocorticoid receptor antagonist tolerability study-diabetic nephropathy (ARTS-DN) study group
-
Bakris GL, Agarwal R, Chan JC, Cooper ME, Gansevoort RT, Haller H, Remuzzi G, Rossing P, Schmieder RE, Nowack C, et al. 2015. Effect of finerenone on albuminuria in patients with diabetic nephropathy: a randomized clinical trial. Mineralocorticoid receptor antagonist tolerability study-diabetic nephropathy (ARTS-DN) study group. JAMA 314:884-894. (doi:10.1001/jama.2015.10081)
-
(2015)
JAMA
, vol.314
, pp. 884-894
-
-
Bakris, G.L.1
Agarwal, R.2
Chan, J.C.3
Cooper, M.E.4
Gansevoort, R.T.5
Haller, H.6
Remuzzi, G.7
Rossing, P.8
Schmieder, R.E.9
Nowack, C.10
-
9
-
-
84861554853
-
Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases
-
Bärfacker L, Kuhl A, Hillisch A, Grosser R, Figueroa-Pérez S, Heckroth H, Nitsche A, Ergüden JK, Gielen-Haertwig H, Schlemmer KH, et al. 2012. Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases. ChemMedChem 7:1385-1403. (doi:10.1002/cmdc.201200081)
-
(2012)
ChemMedChem
, vol.7
, pp. 1385-1403
-
-
Bärfacker, L.1
Kuhl, A.2
Hillisch, A.3
Grosser, R.4
Figueroa-Pérez, S.5
Heckroth, H.6
Nitsche, A.7
Ergüden, J.K.8
Gielen-Haertwig, H.9
Schlemmer, K.H.10
-
10
-
-
84882321401
-
The ARTS of third-generation mineralocorticoid receptor antagonists: achieving cardiovascular benefit with minimized renal side effects?
-
Bauersachs J. 2013. The ARTS of third-generation mineralocorticoid receptor antagonists: achieving cardiovascular benefit with minimized renal side effects? European Heart Journal 34 2426-2428. (doi:10.1093/eurheartj/eht235)
-
(2013)
European Heart Journal
, vol.34
, pp. 2426-2428
-
-
Bauersachs, J.1
-
11
-
-
0006064042
-
Synthesis of spirorenone-a novel highly active aldosterone antagonist
-
Bittler D, Hofmeister H, Laurent H, Nickisch K, Nickolson R, Petzoldt K & Wiechert R. 1982. Synthesis of spirorenone-a novel highly active aldosterone antagonist. Angewandte Chemie 94:718. (doi:10.1002/ange.19820940923)
-
(1982)
Angewandte Chemie
, vol.94
, pp. 718
-
-
Bittler, D.1
Hofmeister, H.2
Laurent, H.3
Nickisch, K.4
Nickolson, R.5
Petzoldt, K.6
Wiechert, R.7
-
12
-
-
59049107132
-
Renal aspirin: will all patients with chronic kidney disease one day take spironolactone?
-
Bomback AS, Kshirsagar AV & Klemmer PJ. 2009. Renal aspirin: will all patients with chronic kidney disease one day take spironolactone? Nature Clinical Practice Nephrology 5 74-75. (doi:10.1038/ncpneph1004)
-
(2009)
Nature Clinical Practice Nephrology
, vol.5
, pp. 74-75
-
-
Bomback, A.S.1
Kshirsagar, A.V.2
Klemmer, P.J.3
-
13
-
-
84954098940
-
Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease
-
Bramlage P, Swift SL, Thoenes M, Minguet J, Ferrero C & Schmieder RE. 2016. Non-steroidal mineralocorticoid receptor antagonism for the treatment of cardiovascular and renal disease. European Journal of Heart Failure 18:28-37. (doi:10.1002/ejhf.444)
-
(2016)
European Journal of Heart Failure
, vol.18
, pp. 28-37
-
-
Bramlage, P.1
Swift, S.L.2
Thoenes, M.3
Minguet, J.4
Ferrero, C.5
Schmieder, R.E.6
-
14
-
-
85017625054
-
-
Kenilworth, NJ, USA: Merck & Co., Inc
-
Brandish PE, Fraley ME, Hershey JC & Steen JT. 2009. Mineralocorticoid Receptor Modulators. Patent WO 2009078934:A1. Kenilworth, NJ, USA: Merck & Co., Inc. (available at: https://www.google.com/patents/WO2009078934A1)
-
(2009)
Mineralocorticoid Receptor Modulators
-
-
Brandish, P.E.1
Fraley, M.E.2
Hershey, J.C.3
Steen, J.T.4
-
15
-
-
0025675680
-
Remodeling of the rat right and left ventricles in experimental hypertension
-
Brilla CG, Pick R, Tan LB, Janicki JS & Weber KT. 1990. Remodeling of the rat right and left ventricles in experimental hypertension. Circulation Research 67:1355-1364. (doi:10.1161/01.RES.67.6.1355)
-
(1990)
Circulation Research
, vol.67
, pp. 1355-1364
-
-
Brilla, C.G.1
Pick, R.2
Tan, L.B.3
Janicki, J.S.4
Weber, K.T.5
-
16
-
-
0021321917
-
The renal action of spirorenone and other 6β, 7β; 15β, 16β-dimethylene-17-spirolactones, a new type of steroidal aldosterone antagonists
-
Casals-Stenzel J, Buse M, Wambach G & Losert W. 1984. The renal action of spirorenone and other 6β, 7β; 15β, 16β-dimethylene-17-spirolactones, a new type of steroidal aldosterone antagonists. Arzneimittelforschung 34:241-246
-
(1984)
Arzneimittelforschung
, vol.34
, pp. 241-246
-
-
Casals-Stenzel, J.1
Buse, M.2
Wambach, G.3
Losert, W.4
-
18
-
-
0000084418
-
Steroidal aldosterone blockers. II
-
Cella JA & Tweit RC. 1959. Steroidal aldosterone blockers. II. Journal of Organic Chemistry 24:1109-1110. (doi:10.1021/jo01090a019)
-
(1959)
Journal of Organic Chemistry
, vol.24
, pp. 1109-1110
-
-
Cella, J.A.1
Tweit, R.C.2
-
20
-
-
0018751096
-
Mechanism of action of a new antialdosterone compound, prorenone
-
Claire M, Rafestin-Oblin ME, Michaud A, Roth-Meyer C & Corvol P. 1979. Mechanism of action of a new antialdosterone compound, prorenone. Endocrinology 104:1194-1200. (doi:10.1210/endo-104-4-1194)
-
(1979)
Endocrinology
, vol.104
, pp. 1194-1200
-
-
Claire, M.1
Rafestin-Oblin, M.E.2
Michaud, A.3
Roth-Meyer, C.4
Corvol, P.5
-
21
-
-
0023854298
-
Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate
-
Cook CS, Hauswald CL, Schoenhard GL, Piper CE, Patel A, Radzialowski FM, Hribar JD, Aksamit W, Finnegan P, Bible RH, et al. 1988. Difference in metabolic profile of potassium canrenoate and spironolactone in the rat: mutagenic metabolites unique to potassium canrenoate. Archives of Toxicology 61:201-212. (doi:10.1007/BF00316635)
-
(1988)
Archives of Toxicology
, vol.61
, pp. 201-212
-
-
Cook, C.S.1
Hauswald, C.L.2
Schoenhard, G.L.3
Piper, C.E.4
Patel, A.5
Radzialowski, F.M.6
Hribar, J.D.7
Aksamit, W.8
Finnegan, P.9
Bible, R.H.10
-
22
-
-
0142180980
-
Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans
-
Cook CS, Berry LM, Bible RH, Hribar JD, Hajdu E & Liu NW. 2003. Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans. Drug Metabolism and Disposition 31:1448-1455. (doi:10.1124/dmd.31.11.1448)
-
(2003)
Drug Metabolism and Disposition
, vol.31
, pp. 1448-1455
-
-
Cook, C.S.1
Berry, L.M.2
Bible, R.H.3
Hribar, J.D.4
Hajdu, E.5
Liu, N.W.6
-
23
-
-
0016687047
-
Antiandrogenic effect of spirolactones: mechanism of action
-
Corvol P, Michaud A, Menard J, Freifeld M & Mahoudeau J. 1975. Antiandrogenic effect of spirolactones: mechanism of action. Endocrinology 97:52-58
-
(1975)
Endocrinology
, vol.97
, pp. 52-58
-
-
Corvol, P.1
Michaud, A.2
Menard, J.3
Freifeld, M.4
Mahoudeau, J.5
-
24
-
-
0019794899
-
Mechanism of the antimineralocorticoid effects of spirolactones
-
Corvol P, Claire M, Oblin ME, Geering K & Rossier B. 1981. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney International 20:1-6. (doi:10.1038/ki.1981.97)
-
(1981)
Kidney International
, vol.20
, pp. 1-6
-
-
Corvol, P.1
Claire, M.2
Oblin, M.E.3
Geering, K.4
Rossier, B.5
-
25
-
-
0018418573
-
Re-evaluation of the antimineralocorticoid effect of the spironolactone metabolite, canrenone, from plasma concentrations determined by a new high-pressure liquid-chromatographic method
-
Dahlöf CG, Lundborg P, Persson BA & Regårdh CG. 1979. Re-evaluation of the antimineralocorticoid effect of the spironolactone metabolite, canrenone, from plasma concentrations determined by a new high-pressure liquid-chromatographic method. Drug Metabolism and Disposition 7:103-107
-
(1979)
Drug Metabolism and Disposition
, vol.7
, pp. 103-107
-
-
Dahlöf, C.G.1
Lundborg, P.2
Persson, B.A.3
Regårdh, C.G.4
-
26
-
-
0023117413
-
Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro
-
de Gasparo M, Joss U, Ramjoué HP, Whitebread SE, Haenni H, Schenkel L, Kraehenbuehl C, Biollaz M, Grob J & Schmidlin J. 1987. Three new epoxy-spirolactone derivatives: characterization in vivo and in vitro. Journal of Pharmacology and Experimental Therapeutics 240:650-656
-
(1987)
Journal of Pharmacology and Experimental Therapeutics
, vol.240
, pp. 650-656
-
-
de Gasparo, M.1
Joss, U.2
Ramjoué, H.P.3
Whitebread, S.E.4
Haenni, H.5
Schenkel, L.6
Kraehenbuehl, C.7
Biollaz, M.8
Grob, J.9
Schmidlin, J.10
-
27
-
-
0024502383
-
Antialdosterones: incidence and prevention of sexual side effects
-
de Gasparo M, Whitebread SE, Preiswerk G, Jeunemaitre X, Corvol P & Menard J. 1989. Antialdosterones: incidence and prevention of sexual side effects. Journal of Steroid Biochemistry 32:223-227. (doi:10.1016/0022-4731(89)90169-6)
-
(1989)
Journal of Steroid Biochemistry
, vol.32
, pp. 223-227
-
-
de Gasparo, M.1
Whitebread, S.E.2
Preiswerk, G.3
Jeunemaitre, X.4
Corvol, P.5
Menard, J.6
-
28
-
-
26944459667
-
Tolerability of spironolactone as adjunctive treatment for heart failure in patients over 75 years of age
-
Dinsdale C, Wani M, Steward J & O'Mahony MS. 2005. Tolerability of spironolactone as adjunctive treatment for heart failure in patients over 75 years of age. Age and Ageing 34:395-398. (doi:10.1093/ageing/afi104)
-
(2005)
Age and Ageing
, vol.34
, pp. 395-398
-
-
Dinsdale, C.1
Wani, M.2
Steward, J.3
O'Mahony, M.S.4
-
29
-
-
47949124405
-
Stroke therapy: is spironolactone the holy grail?
-
Dorrance AM. 2008. Stroke therapy: is spironolactone the holy grail? Endocrinology 149 3761-3763. (doi:10.1210/en.2008-0724)
-
(2008)
Endocrinology
, vol.149
, pp. 3761-3763
-
-
Dorrance, A.M.1
-
30
-
-
0023806995
-
Spironolactone: no longer for hypertension
-
Eds Andrew Herxheimer. London, UK: Consumers' Association Ltd
-
Drug and Therapeutic Bulletin. 1988. Spironolactone: no longer for hypertension. In Drug and Therapeutic Bulletin, vol. 26, p 88. Eds Andrew Herxheimer. London, UK: Consumers' Association Ltd
-
(1988)
In Drug and Therapeutic Bulletin
, vol.26
, pp. 88
-
-
-
31
-
-
84954186502
-
-
Leverkusen, Germany: Bayer Healthcare AG
-
Ergueden JK, Kolkhof P, Sandner P, Kuhl A, Stasch JP, Pook E & Schlemmer KH. 2005. Fluorenone 1, 4,-Dihydropyridin Derivatives. Patent WO 2005087740:A1. Leverkusen, Germany: Bayer Healthcare AG. (available at: https://google.com/patents/WO2005087740A1)
-
(2005)
Fluorenone 1, 4,-Dihydropyridin Derivatives
-
-
Ergueden, J.K.1
Kolkhof, P.2
Sandner, P.3
Kuhl, A.4
Stasch, J.P.5
Pook, E.6
Schlemmer, K.H.7
-
32
-
-
77956909015
-
A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule
-
Fagart J, Hillisch A, Huyet J, Bärfacker L, Fay M, Pleiss U, Pook E, Schäfer S, Rafestin-Oblin ME & Kolkhof P. 2010. A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule. Journal of Biological Chemistry 285:29932-29940. (doi:10.1074/jbc.M110.131342)
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 29932-29940
-
-
Fagart, J.1
Hillisch, A.2
Huyet, J.3
Bärfacker, L.4
Fay, M.5
Pleiss, U.6
Pook, E.7
Schäfer, S.8
Rafestin-Oblin, M.E.9
Kolkhof, P.10
-
33
-
-
0018237474
-
Fatal hyperkalemia and hyperchloremic acidosis. Association with spironolactone in the absence of renal impairment
-
Feinfeld DA & Carvounis CP. 1978. Fatal hyperkalemia and hyperchloremic acidosis. Association with spironolactone in the absence of renal impairment. JAMA 240:1516. (doi:10.1001/jama.1978.03290140058027)
-
(1978)
JAMA
, vol.240
, pp. 1516
-
-
Feinfeld, D.A.1
Carvounis, C.P.2
-
34
-
-
0015430958
-
Subcellular mechanism in the action of the adrenal steroids
-
Feldman D, Funder JW & Edelman IS. 1972. Subcellular mechanism in the action of the adrenal steroids. American Journal of Medicine 53:545-560. (doi:10.1016/0002-9343(72)90152-0)
-
(1972)
American Journal of Medicine
, vol.53
, pp. 545-560
-
-
Feldman, D.1
Funder, J.W.2
Edelman, I.S.3
-
35
-
-
84980360918
-
A randomized controlled study of finerenone vs eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease
-
Filippatos G, Anker SD, Böhm M, Gheorghiade M, Køber L, Krum H, Maggioni AP, Ponikowski P, Voors AA, Zannad F, et al. 2016. A randomized controlled study of finerenone vs eplerenone in patients with worsening chronic heart failure and diabetes mellitus and/or chronic kidney disease. European Heart Journal 37:2105-2114. (doi:10.1093/eurheartj/ehw132)
-
(2016)
European Heart Journal
, vol.37
, pp. 2105-2114
-
-
Filippatos, G.1
Anker, S.D.2
Böhm, M.3
Gheorghiade, M.4
Køber, L.5
Krum, H.6
Maggioni, A.P.7
Ponikowski, P.8
Voors, A.A.9
Zannad, F.10
-
36
-
-
69549084886
-
Trails of discovery: aldosterone antagonists: a model of translational medicine
-
Fitzgerald N & Fitzgerald JD. 2009. Trails of discovery: aldosterone antagonists: a model of translational medicine. Dialogues in Cardiovascular Medicine 14:119-125
-
(2009)
Dialogues in Cardiovascular Medicine
, vol.14
, pp. 119-125
-
-
Fitzgerald, N.1
Fitzgerald, J.D.2
-
37
-
-
21244485815
-
Mineralocorticoid receptors: distribution and activation
-
Funder JW. 2005. Mineralocorticoid receptors: distribution and activation. Heart Failure Reviews 10:15-22. (doi:10.1007/s10741-005-2344-2)
-
(2005)
Heart Failure Reviews
, vol.10
, pp. 15-22
-
-
Funder, J.W.1
-
39
-
-
0016380105
-
Molecular modifications of anti-aldosterone compounds: effects on affinity of spirolactones for renal aldosterone receptors
-
Funder JW, Feldman D, Highland E & Edelman IS. 1974. Molecular modifications of anti-aldosterone compounds: effects on affinity of spirolactones for renal aldosterone receptors. Biochemical Pharmacology 23:1493-1501. (doi:10.1016/0006-2952(74)90386-4)
-
(1974)
Biochemical Pharmacology
, vol.23
, pp. 1493-1501
-
-
Funder, J.W.1
Feldman, D.2
Highland, E.3
Edelman, I.S.4
-
41
-
-
0024442132
-
Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors
-
Funder JW, Pearce PT, Smith R & Campbell J. 1989. Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors. Endocrinology 125:2224-2226
-
(1989)
Endocrinology
, vol.125
, pp. 2224-2226
-
-
Funder, J.W.1
Pearce, P.T.2
Smith, R.3
Campbell, J.4
-
42
-
-
0024477650
-
Spironolactone metabolism: steady-state serum levels of the sulfur-containing metabolites
-
Gardiner P, Schrode K, Quinlan D, Martin BK, Boreham DR, Rogers MS, Stubbs K, Smith M & Karim A. 1989. Spironolactone metabolism: steady-state serum levels of the sulfur-containing metabolites. Journal of Clinical Pharmacology 29:342-347
-
(1989)
Journal of Clinical Pharmacology
, vol.29
, pp. 342-347
-
-
Gardiner, P.1
Schrode, K.2
Quinlan, D.3
Martin, B.K.4
Boreham, D.R.5
Rogers, M.S.6
Stubbs, K.7
Smith, M.8
Karim, A.9
-
44
-
-
0034617130
-
Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy
-
Geller DS, Farhi A, Pinkerton N, Fradley M, Moritz M, Spitzer A, Meinke G, Tsai FT, Sigler PB & Lifton RP. 2000. Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy. Science 289:119-123. (doi:10.1126/science.289.5476.119)
-
(2000)
Science
, vol.289
, pp. 119-123
-
-
Geller, D.S.1
Farhi, A.2
Pinkerton, N.3
Fradley, M.4
Moritz, M.5
Spitzer, A.6
Meinke, G.7
Tsai, F.T.8
Sigler, P.B.9
Lifton, R.P.10
-
45
-
-
0012020788
-
A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma
-
Gochman N & Gantt CL. 1962. A fluorimetric method for the determination of a major spironolactone (Aldactone) metabolite in human plasma. Journal of Pharmacology and Experimental Therapeutics 135:312-316
-
(1962)
Journal of Pharmacology and Experimental Therapeutics
, vol.135
, pp. 312-316
-
-
Gochman, N.1
Gantt, C.L.2
-
46
-
-
84954233101
-
Third-generation mineralocorticoid receptor antagonists: why do we need a fourth?
-
Gomez-Sanchez EP. 2016. Third-generation mineralocorticoid receptor antagonists: why do we need a fourth? Journal of Cardiovascular Pharmacology 67 26-38. (doi:10.1097/FJC.0000000000000329)
-
(2016)
Journal of Cardiovascular Pharmacology
, vol.67
, pp. 26-38
-
-
Gomez-Sanchez, E.P.1
-
47
-
-
0026529495
-
Central mineralocorticoid receptor antagonism blocks hypertension in Dahl S/JR rats
-
Gomez-Sanchez EP, Fort C & Thwaites D. 1992. Central mineralocorticoid receptor antagonism blocks hypertension in Dahl S/JR rats. American Journal of Physiology 262:E96-E99
-
(1992)
American Journal of Physiology
, vol.262
, pp. E96-E99
-
-
Gomez-Sanchez, E.P.1
Fort, C.2
Thwaites, D.3
-
48
-
-
0030889754
-
Steroidal aldosterone antagonists: increased selectivity of 9a1 11-epoxy derivatives
-
Grob J, Boillaz M, Schmidlin J, Wehrli H, Wielanol P, Fuhrer H, Rihs G, Joss U, de Gasparo M, Haenni H, et al. 1997. Steroidal aldosterone antagonists: increased selectivity of 9a1 11-epoxy derivatives. Helvetica Chimica Acta 80:566-585. (doi:10.1002/hlca.19970800220)
-
(1997)
Helvetica Chimica Acta
, vol.80
, pp. 566-585
-
-
Grob, J.1
Boillaz, M.2
Schmidlin, J.3
Wehrli, H.4
Wielanol, P.5
Fuhrer, H.6
Rihs, G.7
Joss, U.8
de Gasparo, M.9
Haenni, H.10
-
49
-
-
84957825109
-
Steroidal and nonsteroidal mineralocorticoid receptor antagonists cause differential cardiac gene expression in pressure overload-induced cardiac hypertrophy
-
Grune J, Benz V, Brix S, Salatzki J, Blumrich A, Höft B, Klopfleisch R, Foryst-Ludwig A, Kolkhof P & Kintscher U. 2016. Steroidal and nonsteroidal mineralocorticoid receptor antagonists cause differential cardiac gene expression in pressure overload-induced cardiac hypertrophy. Journal of Cardiovascular Pharmacology 67:402-411. (doi:10.1097/FJC.0000000000000366)
-
(2016)
Journal of Cardiovascular Pharmacology
, vol.67
, pp. 402-411
-
-
Grune, J.1
Benz, V.2
Brix, S.3
Salatzki, J.4
Blumrich, A.5
Höft, B.6
Klopfleisch, R.7
Foryst-Ludwig, A.8
Kolkhof, P.9
Kintscher, U.10
-
50
-
-
85008474296
-
Finerenone: a new mineralocorticoid receptor antagonist without hyperkalemia: an opportunity in patients with CKD?
-
Haller H, Bertram A, Stahl K & Menne J. 2016. Finerenone: a new mineralocorticoid receptor antagonist without hyperkalemia: an opportunity in patients with CKD? Current Hypertension Reports 18 41. (doi:10.1007/s11906-016-0649-2)
-
(2016)
Current Hypertension Reports
, vol.18
, pp. 41
-
-
Haller, H.1
Bertram, A.2
Stahl, K.3
Menne, J.4
-
51
-
-
0013930709
-
Fatal hyperkalemic paralysis associated with spironalactone. Observation on a patient with severe renal disease and refractory edema
-
Herman E & Rado J. 1966. Fatal hyperkalemic paralysis associated with spironalactone. Observation on a patient with severe renal disease and refractory edema. Archives of Neurology 15:74-77. (doi:10.1001/archneur.1966.00470130078008)
-
(1966)
Archives of Neurology
, vol.15
, pp. 74-77
-
-
Herman, E.1
Rado, J.2
-
54
-
-
0016838629
-
Potassium prorenoate: a new steroidal aldosterone antagonist
-
Hofmann LM, Chinn LJ, Pedrera HA, Krupnick MI & Suleymanov OD. 1975. Potassium prorenoate: a new steroidal aldosterone antagonist. Journal of Pharmacology and Experimental Therapeutics 194:450-456
-
(1975)
Journal of Pharmacology and Experimental Therapeutics
, vol.194
, pp. 450-456
-
-
Hofmann, L.M.1
Chinn, L.J.2
Pedrera, H.A.3
Krupnick, M.I.4
Suleymanov, O.D.5
-
56
-
-
22944433179
-
Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone
-
Hu X, Li S, McMahon EG, Lala DS & Rudolph AE. 2005. Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone. Mini-Reviews in Medicinal Chemistry 5:709-718. (doi:10.2174/1389557054553811)
-
(2005)
Mini-Reviews in Medicinal Chemistry
, vol.5
, pp. 709-718
-
-
Hu, X.1
Li, S.2
McMahon, E.G.3
Lala, D.S.4
Rudolph, A.E.5
-
58
-
-
85023171484
-
-
Silverspring, MD, USA: FDA, US Food and Drug Administration
-
Inspra Prescribing Information. 2002. INSPRA (eplerenone) tablets: highlights of prescribing information. Silverspring, MD, USA: FDA, US Food and Drug Administration (available at: http://www. accessdata.fda.gov/drugsatfda_docs/label/2008/021437s006lbl.pdf)
-
(2002)
INSPRA (eplerenone) tablets: highlights of prescribing information
-
-
-
59
-
-
0023620145
-
Efficacy and tolerance of spironolactone in essential hypertension
-
Jeunemaitre X, Chatellier G, Kreft-Jais C, Charru A, DeVries C, Plouin PF, Corvol P & Menard J. 1987. Efficacy and tolerance of spironolactone in essential hypertension. American Journal of Cardiology 60:820-825. (doi:10.1016/0002-9149(87)91030-7)
-
(1987)
American Journal of Cardiology
, vol.60
, pp. 820-825
-
-
Jeunemaitre, X.1
Chatellier, G.2
Kreft-Jais, C.3
Charru, A.4
DeVries, C.5
Plouin, P.F.6
Corvol, P.7
Menard, J.8
-
60
-
-
3442886513
-
Rates of hyperkalemia after publication of the randomized aldactone evaluation study
-
Juurlink DN, Mamdani MM, Lee DS, Kopp A, Austin PC, Laupacis A & Redelmeier DA. 2004. Rates of hyperkalemia after publication of the randomized aldactone evaluation study. New England Journal of Medicine 351:543-551. (doi:10.1056/NEJMoa040135)
-
(2004)
New England Journal of Medicine
, vol.351
, pp. 543-551
-
-
Juurlink, D.N.1
Mamdani, M.M.2
Lee, D.S.3
Kopp, A.4
Austin, P.C.5
Laupacis, A.6
Redelmeier, D.A.7
-
61
-
-
0000167622
-
Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt
-
Kagawa CM, Cella JA & Van Arman CG. 1957. Action of new steroids in blocking effects of aldosterone and desoxycorticosterone on salt. Science 126:1015-1016. (doi:10.1126/science.126.3281.1015)
-
(1957)
Science
, vol.126
, pp. 1015-1016
-
-
Kagawa, C.M.1
Cella, J.A.2
Van Arman, C.G.3
-
63
-
-
0018164753
-
Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability
-
Karim A. 1978. Spironolactone: disposition, metabolism, pharmacodynamics, and bioavailability. Drug Metabolism Reviews 8:151-188. (doi:10.3109/03602537808993782)
-
(1978)
Drug Metabolism Reviews
, vol.8
, pp. 151-188
-
-
Karim, A.1
-
64
-
-
0015370920
-
Isolation and identification of novel sulfurcontaining metabolites of spironolactone (Aldactone)
-
Karim A & Brown EA. 1972. Isolation and identification of novel sulfurcontaining metabolites of spironolactone (Aldactone). Steroids 20:41-62. (doi:10.1016/0039-128X(72)90117-1)
-
(1972)
Steroids
, vol.20
, pp. 41-62
-
-
Karim, A.1
Brown, E.A.2
-
65
-
-
84856337738
-
Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics
-
Kolkhof P & Borden SA. 2012. Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics. Molecular and Cellular Endocrinology 350:310-317. (doi:10.1016/j. mce.2011.06.025)
-
(2012)
Molecular and Cellular Endocrinology
, vol.350
, pp. 310-317
-
-
Kolkhof, P.1
Borden, S.A.2
-
66
-
-
84904267679
-
Finerenone, a novel selective nonsteroidal mineralocorticoid receptor antagonist protects from rat cardiorenal injury
-
Kolkhof P, Delbeck M, Kretschmer A, Steinke W, Hartmann E, Bärfacker L, Eitner F, Albrecht-Küpper B & Schäfer S. 2014. Finerenone, a novel selective nonsteroidal mineralocorticoid receptor antagonist protects from rat cardiorenal injury. Journal of Cardiovascular Pharmacology 64:69-78. (doi:10.1097/FJC.0000000000000091)
-
(2014)
Journal of Cardiovascular Pharmacology
, vol.64
, pp. 69-78
-
-
Kolkhof, P.1
Delbeck, M.2
Kretschmer, A.3
Steinke, W.4
Hartmann, E.5
Bärfacker, L.6
Eitner, F.7
Albrecht-Küpper, B.8
Schäfer, S.9
-
68
-
-
85020624973
-
Steroidal and novel non-steroidal mineralocorticoid receptor antagonists in heart failure and cardiorenal diseases: comparison at bench and bedside
-
[in press]
-
Kolkhof P, Jaisser F, Kim SY, Filippatos G, Nowack C & Pitt B. 2016. Steroidal and novel non-steroidal mineralocorticoid receptor antagonists in heart failure and cardiorenal diseases: comparison at bench and bedside. Handbook of Experimental Pharmacology [in press]. (doi:10.1007/164_2016_76)
-
(2016)
Handbook of Experimental Pharmacology
-
-
Kolkhof, P.1
Jaisser, F.2
Kim, S.Y.3
Filippatos, G.4
Nowack, C.5
Pitt, B.6
-
69
-
-
0020544634
-
Pharmacokinetics of the new aldosterone antagonist, spirorenone, in healthy volunteers after single and repeated daily doses
-
Krause W, Sack C & Seifert W. 1983. Pharmacokinetics of the new aldosterone antagonist, spirorenone, in healthy volunteers after single and repeated daily doses. European Journal of Clinical Pharmacology 25:231-236. (doi:10.1007/BF00543796)
-
(1983)
European Journal of Clinical Pharmacology
, vol.25
, pp. 231-236
-
-
Krause, W.1
Sack, C.2
Seifert, W.3
-
70
-
-
0000051952
-
Inhibition of the sodium-retaining influence of aldosterone by progesterone
-
Landau RL & Lugibihl K. 1958. Inhibition of the sodium-retaining influence of aldosterone by progesterone. Journal of Clinical Endocrinology and Metabolism 18:1237-1245. (doi:10.1210/jcem-18-11-1237)
-
(1958)
Journal of Clinical Endocrinology and Metabolism
, vol.18
, pp. 1237-1245
-
-
Landau, R.L.1
Lugibihl, K.2
-
72
-
-
0020790594
-
Synthesis and activities of anti-aldosterones
-
Laurent H, Bittler D, Hofmeister H, Nickisch K, Nickolson R, Petzoldt K & Wiechert R. 1983. Synthesis and activities of anti-aldosterones. Journal of Steroid Biochemistry 19:771-776. (doi:10.1016/0022-4731(83)90010-9)
-
(1983)
Journal of Steroid Biochemistry
, vol.19
, pp. 771-776
-
-
Laurent, H.1
Bittler, D.2
Hofmeister, H.3
Nickisch, K.4
Nickolson, R.5
Petzoldt, K.6
Wiechert, R.7
-
73
-
-
37049252880
-
Sodium diuresis induced by steroidal antagonists of aldosterone
-
Liddle GW. 1957. Sodium diuresis induced by steroidal antagonists of aldosterone. Science 126:1016-1018. (doi:10.1126/science.126.3281.1016)
-
(1957)
Science
, vol.126
, pp. 1016-1018
-
-
Liddle, G.W.1
-
74
-
-
0006970374
-
Aldosterone antagonists
-
Liddle GW. 1958. Aldosterone antagonists. Archives of Internal Medicine 102:998-1004. (doi:10.1001/archinte.1958.00260230144018)
-
(1958)
Archives of Internal Medicine
, vol.102
, pp. 998-1004
-
-
Liddle, G.W.1
-
75
-
-
84948958950
-
Finerenone: third-generation mineralocorticoid receptor antagonist for the treatment of heart failure and diabetic kidney disease
-
Liu LC, Schutte E, Gansevoort RT, van der Meer P & Voors AA. 2015. Finerenone: third-generation mineralocorticoid receptor antagonist for the treatment of heart failure and diabetic kidney disease. Expert Opinions on Investigational Drugs 24:1123-1135. (doi:10.1517/135437 84.2015.1059819)
-
(2015)
Expert Opinions on Investigational Drugs
, vol.24
, pp. 1123-1135
-
-
Liu, L.C.1
Schutte, E.2
Gansevoort, R.T.3
van der Meer, P.4
Voors, A.A.5
-
76
-
-
0021925007
-
Progestagens with antimineralocorticoid activity
-
Losert W, Casals-Stenzel J & Buse M. 1985. Progestagens with antimineralocorticoid activity. Drug Research 35:459-471
-
(1985)
Drug Research
, vol.35
, pp. 459-471
-
-
Losert, W.1
Casals-Stenzel, J.2
Buse, M.3
-
77
-
-
0023035320
-
Mespirenone and other 15, 16-methylene-17-spirolactones, a new type of steroidal aldosterone antagonists
-
Losert W, Bittler D, Buse M, Casals-Stenzel J, Haberey M, Laurent H, Nickisch K, Schillinger E & Wiechert R. 1986. Mespirenone and other 15, 16-methylene-17-spirolactones, a new type of steroidal aldosterone antagonists. Arzneimittelforschung 36:1583-1600
-
(1986)
Arzneimittelforschung
, vol.36
, pp. 1583-1600
-
-
Losert, W.1
Bittler, D.2
Buse, M.3
Casals-Stenzel, J.4
Haberey, M.5
Laurent, H.6
Nickisch, K.7
Schillinger, E.8
Wiechert, R.9
-
79
-
-
85023186721
-
Toxikologisches profil von spironolacton und kaliumcanrenoat
-
Ed E Mutschler. München-Wien-Baltimore: Urban & Scharzenberg
-
Mayer DG, Bode G & Radzialowski FM. 1988. Toxikologisches profil von spironolacton und kaliumcanrenoat. In Therapie Mit Aldosteron-Antagonisten. Ed E Mutschler. München-Wien-Baltimore: Urban & Scharzenberg, ISBN 3-541-12741-4
-
(1988)
In Therapie Mit Aldosteron-Antagonisten
-
-
Mayer, D.G.1
Bode, G.2
Radzialowski, F.M.3
-
80
-
-
0020455929
-
Comparison of prorenoate potassium and spironolactone after repeated doses and steady state plasma levels of active metabolites
-
McInnes GT, Shelton JR, Harrison IR, Perkins RM & Palmer RF. 1982. Comparison of prorenoate potassium and spironolactone after repeated doses and steady state plasma levels of active metabolites. British Journal of Clinical Pharmacology 13:187-194. (doi:10.1111/j.1365-2125.1982.tb01354.x)
-
(1982)
British Journal of Clinical Pharmacology
, vol.13
, pp. 187-194
-
-
McInnes, G.T.1
Shelton, J.R.2
Harrison, I.R.3
Perkins, R.M.4
Palmer, R.F.5
-
81
-
-
0021220074
-
Relative potency of prorenoate potassium and spironolactone in attenuating diuretic induced hypokalaemia
-
McInnes GT, Harrison IR, Shelton JR, Perkins RM & Clarke JM. 1984. Relative potency of prorenoate potassium and spironolactone in attenuating diuretic induced hypokalaemia. British Journal of Clinical Pharmacology 18:169-174. (doi:10.1111/j.1365-2125.1984.tb02449.x)
-
(1984)
British Journal of Clinical Pharmacology
, vol.18
, pp. 169-174
-
-
McInnes, G.T.1
Harrison, I.R.2
Shelton, J.R.3
Perkins, R.M.4
Clarke, J.M.5
-
82
-
-
2342511545
-
The 45-year story of the development of an antialdosterone more specific than spironolactone
-
Ménard J. 2004. The 45-year story of the development of an antialdosterone more specific than spironolactone. Molecular and Cellular Endocrinology 217:45-52. (doi:10.1016/j.mce.2003.10.008)
-
(2004)
Molecular and Cellular Endocrinology
, vol.217
, pp. 45-52
-
-
Ménard, J.1
-
83
-
-
0020680946
-
Pharmacokinetics of spironolactone after a single dose: evaluation of the true canrenone serum concentrations during 24 hours
-
Merkus FW, Overdiek JW, Cilissen J & Zuidema J. 1983. Pharmacokinetics of spironolactone after a single dose: evaluation of the true canrenone serum concentrations during 24 hours. Clinical and Experimental Hypertension: Part A, Theory and Practice 5:239-248. (doi:10.3109/10641968309048824)
-
(1983)
Clinical and Experimental Hypertension: Part A, Theory and Practice
, vol.5
, pp. 239-248
-
-
Merkus, F.W.1
Overdiek, J.W.2
Cilissen, J.3
Zuidema, J.4
-
84
-
-
0028910917
-
Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models
-
Muhn P, Krattenmacher R, Beier S, Elger W & Schillinger E. 1995. Drospirenone: a novel progestogen with antimineralocorticoid and antiandrogenic activity. Pharmacological characterization in animal models. Contraception 51:99-110. (doi:10.1016/0010-7824(94)00015-O)
-
(1995)
Contraception
, vol.51
, pp. 99-110
-
-
Muhn, P.1
Krattenmacher, R.2
Beier, S.3
Elger, W.4
Schillinger, E.5
-
85
-
-
84980347489
-
Finerenone in heart failure: walking a fine line
-
Naegele M, Hernandez AF & Ruschitzka F. 2016. Finerenone in heart failure: walking a fine line. European Heart Journal 37:2115-2117. (doi:10.1093/eurheartj/ehw155)
-
(2016)
European Heart Journal
, vol.37
, pp. 2115-2117
-
-
Naegele, M.1
Hernandez, A.F.2
Ruschitzka, F.3
-
86
-
-
85023192128
-
Spironolactone and potassium canrenoate-despite chemical similarities, differing metabolism accounts for different toxicological findings in animals
-
Ed E Mutschler. München-Wien-Baltimore: Urban & Scharzenberg
-
Oppermann JA, Piper C & Gardiner P. 1988. Spironolactone and potassium canrenoate-despite chemical similarities, differing metabolism accounts for different toxicological findings in animals. In Therapie Mit Aldosteron-Antagonisten. Ed E Mutschler. München-Wien-Baltimore: Urban & Scharzenberg, ISBN 3-541-12741-4
-
(1988)
In Therapie Mit Aldosteron-Antagonisten
-
-
Oppermann, J.A.1
Piper, C.2
Gardiner, P.3
-
88
-
-
79954692757
-
A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism
-
Parthasarathy HK, Ménard J, White WB, Young WF Jr, Williams GH, Williams B, Ruilope LM, McInnes GT, Connell JM & MacDonald TM. 2011. A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism. Journal of Hypertension 29:980-990. (doi:10.1097/HJH.0b013e3283455ca5)
-
(2011)
Journal of Hypertension
, vol.29
, pp. 980-990
-
-
Parthasarathy, H.K.1
Ménard, J.2
White, W.B.3
Young, W.F.4
Williams, G.H.5
Williams, B.6
Ruilope, L.M.7
McInnes, G.T.8
Connell, J.M.9
MacDonald, T.M.10
-
89
-
-
0023585013
-
High affinity aldosterone binding sites (type I receptors) in rat heart
-
Pearce P & Funder JW. 1987. High affinity aldosterone binding sites (type I receptors) in rat heart. Clinical and Experimental Pharmacology and Physiology 14:859-866. (doi:10.1111/j.1440-1681.1987.tb02422.x)
-
(1987)
Clinical and Experimental Pharmacology and Physiology
, vol.14
, pp. 859-866
-
-
Pearce, P.1
Funder, J.W.2
-
90
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators
-
Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, Palensky J & Wittes J. 1999. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. New England Journal of Medicine 341:709-717. (doi:10.1056/NEJM199909023411001)
-
(1999)
New England Journal of Medicine
, vol.341
, pp. 709-717
-
-
Pitt, B.1
Zannad, F.2
Remme, W.J.3
Cody, R.4
Castaigne, A.5
Perez, A.6
Palensky, J.7
Wittes, J.8
-
91
-
-
0037417252
-
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
-
Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J & Gatlin M. 2003. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. New England Journal of Medicine 348:1309-1321. (doi:10.1056/NEJMoa030207)
-
(2003)
New England Journal of Medicine
, vol.348
, pp. 1309-1321
-
-
Pitt, B.1
Remme, W.2
Zannad, F.3
Neaton, J.4
Martinez, F.5
Roniker, B.6
Bittman, R.7
Hurley, S.8
Kleiman, J.9
Gatlin, M.10
-
92
-
-
84861563400
-
Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease
-
Pitt B, Filippatos G, Gheorghiade M, Kober L, Krum H, Ponikowski P, Nowack C, Kolkhof P, Kim SY & Zannad F. 2012. Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease. European Journal of Heart Failure 14:668-675. (doi:10.1093/eurjhf/hfs061)
-
(2012)
European Journal of Heart Failure
, vol.14
, pp. 668-675
-
-
Pitt, B.1
Filippatos, G.2
Gheorghiade, M.3
Kober, L.4
Krum, H.5
Ponikowski, P.6
Nowack, C.7
Kolkhof, P.8
Kim, S.Y.9
Zannad, F.10
-
93
-
-
84882415231
-
Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial
-
Pitt B, Kober L, Ponikowski P, Gheorghiade M, Filippatos G, Krum H, Nowack C, Kolkhof P, Kim SY & Zannad F. 2013. Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial. European Heart Journal 34:2453-2463. (doi:10.1093/eurheartj/eht187)
-
(2013)
European Heart Journal
, vol.34
, pp. 2453-2463
-
-
Pitt, B.1
Kober, L.2
Ponikowski, P.3
Gheorghiade, M.4
Filippatos, G.5
Krum, H.6
Nowack, C.7
Kolkhof, P.8
Kim, S.Y.9
Zannad, F.10
-
94
-
-
0015734378
-
Hyperkalemic cardiac arrhythmia secondary to spironolactone
-
Pongpaew C, Songkhla RN & Kozam RL. 1973. Hyperkalemic cardiac arrhythmia secondary to spironolactone. Chest 63:1023-1025. (doi:10.1378/chest.63.6.1023)
-
(1973)
Chest
, vol.63
, pp. 1023-1025
-
-
Pongpaew, C.1
Songkhla, R.N.2
Kozam, R.L.3
-
96
-
-
0036838616
-
Aldosterone induces a vascular inflammatory phenotype in the rat heart
-
Rocha R, Rudolph AE, Frierdich GE, Nachowiak DA, Kekec BK, Blomme EA, McMahon EG & Delyani JA. 2002. Aldosterone induces a vascular inflammatory phenotype in the rat heart. American Journal of Physiology: Heart and Circulatory Physiology 283:H1802-H1810. (doi:10.1152/ajpheart.01096.2001)
-
(2002)
American Journal of Physiology: Heart and Circulatory Physiology
, vol.283
, pp. H1802-H1810
-
-
Rocha, R.1
Rudolph, A.E.2
Frierdich, G.E.3
Nachowiak, D.A.4
Kekec, B.K.5
Blomme, E.A.6
McMahon, E.G.7
Delyani, J.A.8
-
99
-
-
0019977854
-
Pharmacological investigation on the effect of ZK 35973 (spirorenone INN), a new aldosterone antagonist in man
-
abstract 106
-
Seifert W, Groß C, Krais T & Müller U. 1982. Pharmacological investigation on the effect of ZK 35973 (spirorenone INN), a new aldosterone antagonist in man. Acta Endocrinologica 99:(Supplement 246) abstract 106. (doi:10.1530/acta.0.0990III)
-
(1982)
Acta Endocrinologica
, vol.99
-
-
Seifert, W.1
Groß, C.2
Krais, T.3
Müller, U.4
-
100
-
-
0012651250
-
Production of nephrosclerosis by overdosage with desoxycorticosterone acetate
-
Selye H. 1942. Production of nephrosclerosis by overdosage with desoxycorticosterone acetate. Canadian Medical Association Journal 47:515-519
-
(1942)
Canadian Medical Association Journal
, vol.47
, pp. 515-519
-
-
Selye, H.1
-
101
-
-
84954981008
-
The general adaptation syndrome and the diseases of adaptation
-
Selye H. 1946. The general adaptation syndrome and the diseases of adaptation. Journal of Clinical Endocrinology and Metabolism 6:117-230. (doi:10.1210/jcem-6-2-117)
-
(1946)
Journal of Clinical Endocrinology and Metabolism
, vol.6
, pp. 117-230
-
-
Selye, H.1
-
102
-
-
37049249617
-
Anticortisol action of aldosterone
-
Selye H. 1955. Anticortisol action of aldosterone. Science 121:368-369. (doi:10.1126/science.121.3141.368)
-
(1955)
Science
, vol.121
, pp. 368-369
-
-
Selye, H.1
-
103
-
-
0038819295
-
Protection by a steroid-spirolactone against certain types of cardiac necroses
-
Selye H. 1960. Protection by a steroid-spirolactone against certain types of cardiac necroses. Proceedings of the Society for Experimental Biology and Medicine 104:212-213. (doi:10.3181/00379727-104-25782)
-
(1960)
Proceedings of the Society for Experimental Biology and Medicine
, vol.104
, pp. 212-213
-
-
Selye, H.1
-
104
-
-
21244485814
-
Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis
-
Sica DA. 2005. Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis. Heart Failure Reviews 10:23-29. (doi:10.1007/s10741-005-2345-1)
-
(2005)
Heart Failure Reviews
, vol.10
, pp. 23-29
-
-
Sica, D.A.1
-
105
-
-
84887224582
-
A lesson to be gained from basic research programs
-
Sturtevant FM. 1992. A lesson to be gained from basic research programs. Current Contents 35:9
-
(1992)
Current Contents
, vol.35
, pp. 9
-
-
Sturtevant, F.M.1
-
106
-
-
0008853010
-
Spironolactone and gynaecomastia
-
Smith WG. 1962. Spironolactone and gynaecomastia. Lancet 280:886. (doi:10.1016/S0140-6736(62)90668-2)
-
(1962)
Lancet
, vol.280
, pp. 886
-
-
Smith, W.G.1
-
107
-
-
4143062592
-
How prevalent is hyperkalemia and renal dysfunction during treatment with spironolactone in patients with congestive heart failure?
-
Svensson M, Gustafsson F, Galatius S, Hildebrandt PR & Atar D. 2004. How prevalent is hyperkalemia and renal dysfunction during treatment with spironolactone in patients with congestive heart failure? Journal of Cardiac Failure 10 297-303. (doi:10.1016/j.cardfail.2003.10.012)
-
(2004)
Journal of Cardiac Failure
, vol.10
, pp. 297-303
-
-
Svensson, M.1
Gustafsson, F.2
Galatius, S.3
Hildebrandt, P.R.4
Atar, D.5
-
108
-
-
84910274043
-
The role of potassium in the natriuretic response to a steroidal lactone (SC-9420)
-
Taylor FF & Faloon WW. 1959. The role of potassium in the natriuretic response to a steroidal lactone (SC-9420). Journal of Clinical Endocrinology and Metabolism 19:1683-1687. (doi:10.1210/jcem-19-12-1683)
-
(1959)
Journal of Clinical Endocrinology and Metabolism
, vol.19
, pp. 1683-1687
-
-
Taylor, F.F.1
Faloon, W.W.2
-
109
-
-
84996340730
-
The effect of sex hormones on the renal excretion of electrolytes
-
Thorn GW & Engel LL. 1938. The effect of sex hormones on the renal excretion of electrolytes. Journal of Experimental Medicine 68:299-312. (doi:10.1084/jem.68.3.299)
-
(1938)
Journal of Experimental Medicine
, vol.68
, pp. 299-312
-
-
Thorn, G.W.1
Engel, L.L.2
-
111
-
-
0021889021
-
Assessment of the antimineralocorticoid effect of RU 28318 in healthy men with induced exogenous and endogenous hypermineralocorticism
-
Ulmann A, Bertagna C, Le Go A, Husson JM, Tache A, Sassano P, Menard J & Corvol P. 1985. Assessment of the antimineralocorticoid effect of RU 28318 in healthy men with induced exogenous and endogenous hypermineralocorticism. European Journal of Clinical Pharmacology 28:531-535. (doi:10.1007/BF00544063)
-
(1985)
European Journal of Clinical Pharmacology
, vol.28
, pp. 531-535
-
-
Ulmann, A.1
Bertagna, C.2
Le Go, A.3
Husson, J.M.4
Tache, A.5
Sassano, P.6
Menard, J.7
Corvol, P.8
-
112
-
-
85023176546
-
-
In New York Magazine. New York, NY, USA: New York Media, LLC
-
Vonder Haar TA & Miller M. 1977. Warning: your prescription may be dangerous to your health. In New York Magazine, pp 46-57. New York, NY, USA: New York Media, LLC
-
(1977)
Warning: your prescription may be dangerous to your health
, pp. 46-57
-
-
Vonder Haar, T.A.1
Miller, M.2
-
113
-
-
0035997359
-
Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension
-
Weinberger MH, Roniker B, Krause SL & Weiss RJ. 2002. Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension. American Journal of Hypertension 15:709-716. (doi:10.1016/S0895-7061(02)02957-6)
-
(2002)
American Journal of Hypertension
, vol.15
, pp. 709-716
-
-
Weinberger, M.H.1
Roniker, B.2
Krause, S.L.3
Weiss, R.J.4
-
114
-
-
84959331256
-
Mineralocorticoid receptor antagonistspharmacodynamics and pharmacokinetic differences
-
Yang J & Young MJ. 2016. Mineralocorticoid receptor antagonistspharmacodynamics and pharmacokinetic differences. Current Opinions in Pharmacology 27:78-85. (doi:10.1016/j. coph.2016.02.005)
-
(2016)
Current Opinions in Pharmacology
, vol.27
, pp. 78-85
-
-
Yang, J.1
Young, M.J.2
-
115
-
-
78650399880
-
Eplerenone in patients with systolic heart failure and mild symptoms
-
Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ & Pitt B. 2011. Eplerenone in patients with systolic heart failure and mild symptoms. New England Journal of Medicine 364:11-21. (doi:10.1056/NEJMoa1009492)
-
(2011)
New England Journal of Medicine
, vol.364
, pp. 11-21
-
-
Zannad, F.1
McMurray, J.J.2
Krum, H.3
van Veldhuisen, D.J.4
Swedberg, K.5
Shi, H.6
Vincent, J.7
Pocock, S.J.8
Pitt, B.9
|