Development and evaluation of live influenza (LIV) cold-adapted reassortant vaccines in cell culture

International Congress Series

Volumn 1263, Issue C, 2004, Pages 551-554

  Kiseleva, I ^a,b   Su, Q ^a   Toner, T ^a   Szymkowiak, C ^a   Kwan, W S ^a   Kraiouchkine, N ^a   Rudenko, L ^b   Shaw, A ^a   Youil, R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Russian Federation)

Author keywords

Cold adapted; Influenza; Reassortant

Indexed keywords

EID: 85023068543     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2004.02.158     Document Type: Article

References (4)

1. Kiseleva, I, et al. Cell based assay for the determination of temperature sensitive and cold adapted phenotype of influenza viruses. J. Virol. Methods 116 (2004), 71–78.
2. Klimov, A.I, Cox, N.J, PCR restriction analysis of genome composition and stability of cold-adapted reassortant live influenza vaccines. J. Virol. Methods 52 (1995), 41–49.
3. Feng, S.-Y, et al. Genetic recombination between temperature-sensitive and wild-type influenza A virus strains. Acta Virol. 27 (1983), 21–26.
4. Youil, Phenotypic and genetic analysis of the heterogeneous population present in the cold-adapted master donor strain: A/Leningrad/134/17/57 (H2N2) Virus Research (2004) in press.