Evaluation of anti-inflammatory activity of nigella sativa: An experimental study

National Journal of Physiology, Pharmacy and Pharmacology

Volumn 7, Issue 7, 2017, Pages 707-711

  Pise, Harshal N ^a   Padwal, Sudhir L ^a  

^a SRTR Medical College   (India)

Author keywords

Anti inflammatory; Fixed oil; Formaldehyde induced arthritis; Nigella sativa; Paw edema

Indexed keywords

ACETYLSALICYLIC ACID; CARRAGEENAN; FORMALDEHYDE; NIGELLA SATIVA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTHRITIS; ARTICLE; BLACK CUMIN; CONTROLLED STUDY; DRY WEIGHT; FEMALE; GRANULOMA; MALE; NONHUMAN; PAW EDEMA; RAT;

EID: 85021920416     PISSN: 23204672     EISSN: 22313206     Source Type: Journal    
DOI: 10.5455/njppp.2017.7.0204705032017     Document Type: Article

References (17)

1. th ed. Noida, India: Elsevier Publications; 2004. p. 47-86.
2. Jaiswal SR, Sontakke SD. Experimental evaluation of analgesic and anti-inflammatory activity of simvastatin and atorvastatin. Indian J Pharmacol. 2012;44(4):475-9.
3. Paarakh PM. Nigella sativa Linn. - A comprehensive review. Indian J Nat Prod Resour. 2010;1(4):409-29.
4. Bamosa AO, Ali BA, Sowayan SA. Effect of oral ingestion of Nigella sativa seeds on some blood parameters. Saudi Pharm J. 1997;5:126-9.
5. Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 1995;61(1):33-6.
6. Ghannadi A, Hajhashemi V, Jafarabadi H. An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. J Med Food. 2005;8(4):488-93.
7. Tekeoglu I, Dogan A, Ediz L, Budancamanak M, Demirel A. Effects of thymoquinone (Volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res. 2007;21(9):895-7.
8. Abdel-Sater KA. Gastroprotective effects of Nigella sativa oil on the formation of stress gastritis in hypothyroidal rats. Int J Physiol Pathophysiol Pharmacol. 2009;1(2):143-9.
9. Winter CA, Risley EA, Nuss GW. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 1962;111:544-7.
10. Singh H, Ghosh MN. Modified plethysmometer for measuring foot volume of unanesthetized rats. J Pharm Pharmacol. 1968;20(4):316-7.
11. Winter CA, Porter CC. Effect of alterations in side chain upon anti-inflammatory and liver glycogen activities of hydrocortisone esters. J Am Pharm Assoc Am Pharm Assoc. 1957;46(9):515-9.
12. Brownlee G. Effect of deoxycortone and ascorbic acid on formaldehyde-induced arthritis in normal and adrenalectomized rats. Lancet. 1950;1(6596):157-9.
13. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res. 2004;18(3):195-9.
14. Mutabagani A, El-Mahdy SA. A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone in parts. Saudi Pharm J. 1997;5(2):110-3.
15. Al-Ghamdi MS. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol. 2001;76(1):45-8.
16. Vinegar R, Schreiber W, Hugo R. Biphasic development of carrageenin edema in rats. J Pharmacol Exp Ther. 1969;166(1):96-103.
17. El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, et al. Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol. 2002;2(1):1603-11.