Hypercapnia during acute respiratory distress syndrome: The tree that hides the forest!

Journal of Thoracic Disease

Volumn 9, Issue 6, 2017, Pages 1420-1425

  Repessé, Xavier ^a   Vieillard Baron, Antoine ^a,b  

^a HÔPITAL AMBROISE PARÉ   (France)

^b LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE TENSION; COR PULMONALE; EDITORIAL; HEART PROTECTION; HEART RIGHT VENTRICLE; HEART RIGHT VENTRICLE FAILURE; HUMAN; HYPERCAPNIA; INFLAMMATION; LUNG CIRCULATION; MORTALITY; PULMONARY HYPERTENSION; RESPIRATORY DISTRESS; SEPSIS; VENTILATOR;

EID: 85021358197     PISSN: 20721439     EISSN: 20776624     Source Type: Journal    
DOI: 10.21037/jtd.2017.05.69     Document Type: Editorial

References (44)

1. Nin N, Muriel A, Peñuelas O, et al. Severe hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome. Intensive Care Med 2017;43:200-8
2. Esteban A, Anzueto A, Frutos F, et al. Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study. JAMA 2002;287:345-55
3. Esteban A, Ferguson ND, Meade MO, et al. Evolution of mechanical ventilation in response to clinical research. Am J Respir Crit Care Med 2008;177:170-7
4. Esteban A, Frutos-Vivar F, Muriel A, et al. Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med 2013;188:220-30
5. ARDS Definition Task Force., Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: the Berlin Definition. JAMA 2012;307:2526-33
6. Laffey JG, Kavanagh BP. Carbon dioxide and the critically ill-too little of a good thing? Lancet 1999;354:1283-6
7. Beitler JR, Hubmayr RD, Malhotra A. CrossTalk opposing view: there is not added benefit to providing permissive hypercapnia in the treatment of ARDS. J Physiol 2013;591:2767-9
8. Curley GF, Laffey JG, Kavanagh BP. CrossTalk proposal: there is added benefit to providing permissive hypercapnia in the treatment of ARDS. J Physiol 2013;591:2763-5
9. Hickling KG, Henderson SJ, Jackson R. Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome. Intensive Care Med 1990;16:372-7
10. Hickling KG, Walsh J, Henderson S, et al. Low mortality rate in adult respiratory distress syndrome using lowvolume, pressure-limited ventilation with permissive hypercapnia: a prospective study. Crit Care Med 1994;22:1568-78
11. Laffey JG, Tanaka M, Engelberts D, et al. Therapeutic hypercapnia reduces pulmonary and systemic injury following in vivo lung reperfusion. Am J Respir Crit Care Med 2000;162:2287-94
12. Broccard AF, Hotchkiss JR, Vannay C, et al. Protective effects of hypercapnic acidosis on ventilator-induced lung injury. Am J Respir Crit Care Med 2001;164:802-6
13. Sinclair SE, Kregenow DA, Lamm WJ, et al. Hypercapnic acidosis is protective in an in vivo model of ventilatorinduced lung injury. Am J Respir Crit Care Med 2002;166:403-8
14. Doerr CH, Gajic O, Berrios JC, et al. Hypercapnic acidosis impairs plasma membrane wound resealing in ventilator-injured lungs. Am J Respir Crit Care Med 2005;171:1371-7
15. Jaitovich A, Angulo M, Lecuona E, et al. High CO2 levels cause skeletal muscle atrophy via AMP-activated kinase (AMPK), FoxO3a protein, and muscle-specific Ring finger protein 1 (MuRF1). J Biol Chem 2015;290:9183-94
16. Boissier F, Katsahian S, Razazi K, et al. Prevalence and prognosis of cor pulmonale during protective ventilation for acute respiratory distress syndrome. Intensive Care Med 2013;39:1725-33
17. Mekontso Dessap A, Charron C, Devaquet J, et al. Impact of acute hypercapnia and augmented positive endexpiratory pressure on right ventricle function in severe acute respiratory distress syndrome. Intensive Care Med 2009;35:1850-8
18. Jerusalem E, Starling EH. On the significance of carbon dioxide for the heart beat. J Physiol 1910;40:279-94
19. Brofman JD, Leff AR, Munoz NM, et al. Sympathetic secretory response to hypercapnic acidosis in swine. J Appl Physiol 1990;69:710-7
20. Viitanen A, Salmenperä M, Heinonen J. Right ventricular response to hypercarbia after cardiac surgery. Anesthesiology 1990;73:393-400
21. Carvalho CR, Barbas CS, Medeiros DM, et al. Temporal hemodynamic effects of permissive hypercapnia associated with ideal PEEP in ARDS. Am J Respir Crit Care Med 1997;156:1458-66
22. Jardin F, Dubourg O, Bourdarias JP. Echocardiographic pattern of acute cor pulmonale. Chest 1997:111:209-17
23. Whittenberger JL, McGregor M, Berglund E, et al. Influence of state of inflation of the lung on pulmonary vascular resistance. J Appl Physiol 1960;15:878-82
24. Zapol WM, Kobayashi K, Snider MT, et al. Vascular obstruction causes pulmonary hypertension in severe acute respiratory failure. Chest 1977;71:306-7
25. Price LC, McAuley DF, Marino PS, et al. Pathophysiology of pulmonary hypertension in acute lung injury. Am J Physiol Lung Cell Mol Physiol 2012;302:L803-15
26. Bull TM, Clark B, McFann K, et al. Pulmonary vascular dysfunction is associated with poor outcomes in patients with acute lung injury. Am J Respir Crit Care Med 2010;182:1123-8
27. Mekontso Dessap A, Boissier F, Charron C, et al. Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. Intensive Care Med 2016;42:862-70
28. Charron C, Repessé X, Bouferrache K, et al. PaCO2 and alveolar dead space are more relevant than PaO2/FiO2 ratio in monitoring the respiratory response to prone position in ARDS patients: a physiological study. Crit Care 2011;15:R175
29. Vieillard-Baron A, Charron C, Caille V, et al. Prone positioning unloads the right ventricle in severe ARDS. Chest 2007;132:1440-6
30. Guérin C, Reignier J, Richard JC, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 2013;368:2159-68
31. Acute Respiratory Distress Syndrome Network., Brower RG, Matthay MA, et al. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 2000;342:1301-8
32. Slutsky AS, Ranieri VM. Mechanical ventilation: lessons from the ARDSNet trial. Respir Res 2000;1:73-7
33. Tobin MJ. Culmination of an era in research on the acute respiratory distress syndrome. N Engl J Med 2000;342:1360-1
34. Vieillard-Baron A, Prin S, Augarde R, et al. Increasing respiratory rate to improve CO2 clearance during mechanical ventilation is not a panacea in acute respiratory failure. Crit Care Med 2002;30:1407-12
35. Pepe PE, Marini JJ. Occult positive end-expiratory pressure in mechanically ventilated patients with airflow obstruction: the auto-PEEP effect. Am Rev Respir Dis 1982;126:166-70
36. Prin S, Chergui K, Augarde R, et al. Ability and safety of a heated humidifier to control hypercapnic acidosis in severe ARDS. Intensive Care Med 2002;28:1756-60
37. Aguirre-Bermeo H, Moran I, Bottiroli M, et al. Endinspiratory pause prolongation in acute respiratory distress syndrome patients: effects on gas exchange and mechanics. Ann Intensive Care 2016;6:81
38. Mercat A, Titiriga M, Anguel N, et al. Inverse ratio ventilation (I/E = 2/1) in acute respiratory distress syndrome: a six-hour controlled study. Am J Respir Crit Care Med 1997;155:1637-42
39. Vieillard-Baron A, Rabiller A, Chergui K, et al. Prone position improves mechanics and alveolar ventilation in acute respiratory distress syndrome. Intensive Care Med 2005;31:220-6
40. Enson Y, Giuntini C, Lewis ML, et al. The Influence of Hydrogen Ion Concentration and Hypoxia on the Pulmonary Circulation. J Clin Invest 1964;43:1146-62
41. Morimont P, Guiot J, Desaive T, et al. Veno-venous extracorporeal CO2 removal improves pulmonary hemodynamics in a porcine ARDS model. Acta Anaesthesiol Scand 2015;59:448-56
42. Vieillard-Baron A, Matthay M, Teboul JL, et al. Experts' opinion on management of hemodynamics in ARDS patients: focus on the effects of mechanical ventilation. Intensive Care Med 2016;42:739-49
43. Vieillard-Baron A, Price LC, Matthay MA. Acute cor pulmonale in ARDS. Intensive Care Med 2013;39:1836-8
44. Repessé X, Charron C, Vieillard-Baron A. Acute cor pulmonale in ARDS: rationale for protecting the right ventricle. Chest 2015;147:259-65