Diagnostic accuracy and cost analysis of the Alere™ i Influenza A&B near-patient test using throat swabs

Journal of Hospital Infection

Volumn 97, Issue 3, 2017, Pages 301-309

  Davis, S ^a   Allen, A J ^b,c   O'Leary, R ^b   Power, M ^b   Price, D A ^d   Simpson, A J ^b,c   Tunbridge, A ^a   Vale, L ^c   Whiteside, M ^e   Evans, C ^a   Raza, M ^a  

^a SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b National Institute for Health Research ^*  (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

^e DONCASTER ROYAL INFIRMARY   (United Kingdom)

Author keywords

Adults; Alere i; Cost analysis; Infection control; Influenza; Point of care testing; Respiratory viruses

Indexed keywords

OSELTAMIVIR;

ADULT; AGED; ARTICLE; CLINICAL OUTCOME; COHORT ANALYSIS; CONTROLLED STUDY; COST BENEFIT ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DRUG COST; FEMALE; HEALTH CARE COST; HUMAN; INFLUENZA A; INFLUENZA B; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NATIONAL HEALTH SERVICE; PATIENT ISOLATION; POINT OF CARE TESTING; PREDICTIVE VALUE; PROSPECTIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SEROPREVALENCE; THROAT CULTURE; TIME FACTOR; UNITED KINGDOM; VIRUS DETECTION; CLINICAL TRIAL; COST; DIAGNOSTIC TEST; ECONOMICS; EVALUATION STUDY; INFLUENZA; MIDDLE AGED; PHARYNX; PROCEDURES; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; COSTS AND COST ANALYSIS; DIAGNOSTIC TESTS, ROUTINE; FEMALE; HUMANS; INFLUENZA, HUMAN; MALE; MIDDLE AGED; PHARYNX; POINT-OF-CARE TESTING; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; TIME FACTORS; UNITED KINGDOM; YOUNG ADULT;

EID: 85021324111     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2017.05.017     Document Type: Article

References (24)

1. Dugas, A.F., Valsamakis, A., Atreya, M.R., Thind, K., Alarcon Manchego, P., Faisal, A., et al. Clinical diagnosis of influenza in the ED. Am J Emerg Med 33 (2015), 770–775.
2. Stein, J., Louie, J., Flanders, S., Maselli, J., Hacker, J.K., Drew, W.L., et al. Performance characteristics of clinical diagnosis, a clinical decision rule, and a rapid influenza test in the detection of influenza infection in a community sample of adults. Ann Emerg Med 46 (2005), 412–419.
3. Davis, S., Clinical evaluation of near patient testing for influenza A and B using the Alere-I rapid nucleic amplification technique compared to standard laboratory based real-time PCR. Oral presentation, Federation of Infection Societies Conference, Harrogate, UK, 2014.
4. Louie, J.K., Yang, S., Acosta, M., Yen, C., Samuel, M.C., Schechter, R., et al. Treatment with neuraminidase inhibitors for critically ill patients with influenza A (H1N1)pdm09. Clin Infect Dis 55 (2012), 1198–1204.
5. Lillie, P.J., Bazaz, R., Dexter, L., Biju, C., Peart, L., Lewis, L., et al. Severity assessment of influenza virus infection in secondary care. J Infect 64 (2012), 239–241.
6. van Doorn, H.R., Kinh, N., Tuan, H.M., Tuan, T.A., Minh, N.N., Bryant, J.E., et al. Clinical validation of a point-of-care multiplexed in vitro immunoassay using monoclonal antibodies (the MSD influenza test) in four hospitals in Vietnam. J Clin Microbiol 50 (2012), 1621–1625.
7. Dale, S.E., Mayer, C., Mayer, M.C., Menegus, M.A., Analytical and clinical sensitivity of the 3M rapid detection influenza A+B assay. J Clin Microbiol 46 (2008), 3804–3807.
8. Hurt, A.C., Alexander, R., Hibbert, J., Deed, N., Barr, I.G., Performance of six influenza rapid tests in detecting human influenza in clinical specimens. J Clin Virol 39 (2007), 132–135.
9. Hannoun, C., Tumova, B., Survey on influenza laboratory diagnostic and surveillance methods in Europe. European Scientific Working Group on Influenza. Eur J Epidemiol 16 (2000), 217–222.
10. Leonardi, G.P., Rapid identification of 2009 H1N1 influenza A virus using fluorescent antibody methods. Am J Clin Pathol 134 (2010), 910–914.
11. Salez, N., Nougairede, A., Ninove, L., Zandotti, C., de Lamballerie, X., Charrel, R.N., Prospective and retrospective evaluation of the Cepheid Xpert(R) Flu/RSV XC assay for rapid detection of influenza A, influenza B, and respiratory syncytial virus. Diagn Microbiol Infect Dis 81 (2015), 256–258.
12. Hurtado, J.C., Mosquera, M.M., de Lazzari, E., Martínez, E., Torner, N., Isanta, R., et al. Evaluation of a new, rapid, simple test for the detection of influenza virus. BMC Infect Dis, 15, 2015, 44 (Erratum in BMC Infect Dis 2015).
13. Nguyen Van, J.C., Camelena, F., Dahoun, M., Pilmis, B., Mizrahi, A., Lourtet, J., et al. Prospective evaluation of the Alere i Influenza A&B nucleic acid amplification versus Xpert Flu/RSV. Diagn Microbiol Infect Dis 85 (2016), 19–22.
14. Nie, S., Roth, R.B., Stiles, J., Mikhlina, A., Lu, X., Tang, Y.W., et al. Evaluation of Alere i Influenza A&B for rapid detection of influenza viruses A and B. J Clin Microbiol 52 (2014), 3339–3344.
15. Jokela, P., Vuorinen, T., Waris, M., Manninen, R., Performance of the Alere i influenza A&B assay and mariPOC test for the rapid detection of influenza A and B viruses. J Clin Virol 70 (2015), 72–76.
16. Beckmann, C., Hirsch, H.H., Diagnostic performance of near-patient testing for influenza. J Clin Virol 67 (2015), 43–46.
17. Hazelton, B., Gray, T., Ho, J., Ratnamohan, V.M., Dwyer, D.E., Kok, J., Detection of influenza A and B with the Alere i Influenza A & B: a novel isothermal nucleic acid amplification assay. Influenza Other Respir Viruses 9 (2015), 151–154.
18. Bell, J.J., Selvarangan, R., Evaluation of the Alere I influenza A&B nucleic acid amplification test by use of respiratory specimens collected in viral transport medium. J Clin Microbiol 52 (2014), 3992–3995.
19. Riazzo, C., Perez-Ruiz, M., Sanbonmatsu-Gamez, S., Pedrosa-Corral, I., Gutierrez-Fernandez, J., Navarro-Mari, J.M., Analytical performance of the Alere i Influenza A&B assay for the rapid detection of influenza viruses. Enferm Infec Microbiol Clin, 2015, 10.1016/j.eimc.2015.10.006.
20. Bell, J., Bonner, A., Cohen, D.M., Birkhahn, R., Yogev, R., Triner, W., et al. Multicenter clinical evaluation of the novel Alere i Influenza A&B isothermal nucleic acid amplification test. J Clin Virol 61 (2014), 81–86.
21. Monthly Index of Medical Specialties (MIMS). 2014 Available at: www.mims.co.uk/drugs/infections-and-infestations/viral-infections/tamiflu [last accessed June 2017].
22. Health Protection Scotland. NHS Scotland MRSA Screening Pathfinder Programme Final Report Volume 2: An assessment of the economics, implementation and modelling of universal MRSA screening. 2011. http://www.documents.hps.scot.nhs.uk/hai/mrsa-screening/pathfinder-programme/mrsa-pathfinder-vol2-2011-02-23.pdf [last accessed June 2017].
23. electronic Medicines Compendium (eMC). Tamiflu 75mg hard capsule. Available at: https://www.medicines.org.uk/emc/medicine/20294 [last accessed June 2017].
24. Nicholson, K.G., Abrams, K.R., Batham, S., Medina, M.J., Warren, F.C., Barer, M., et al. Randomised controlled trial and health economic evaluation of the impact of diagnostic testing for influenza, respiratory syncytial virus and Streptococcus pneumoniae infection on the management of acute admissions in the elderly and high-risk 18- to 64-year-olds. Health Technol Assessm 18 (2014), 1–274 vii–viii.