메뉴 건너뛰기




Volumn 15, Issue 10, 2017, Pages 1557-1564.e1

Histologic Normalization Occurs in Ulcerative Colitis and Is Associated With Improved Clinical Outcomes

Author keywords

Histopathology; Inflammatory Bowel Disease; Mucosal Healing; Normalization

Indexed keywords

ADULT; ARTICLE; CALCULATION; CLINICAL EVALUATION; COLON MUCOSA; COLONOSCOPY; CONTROLLED STUDY; DIGESTIVE SYSTEM DISEASE ASSESSMENT; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCOSAL DISEASE; NEUTROPHIL CHEMOTAXIS; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PREVALENCE; RECTUM HEMORRHAGE; RECURRENCE FREE SURVIVAL; REMISSION; RETROSPECTIVE STUDY; RISK FACTOR; SIMPLE CLINICAL COLITIS ACTIVITY INDEX SCORE; ULCERATIVE COLITIS; BIOPSY; CASE CONTROL STUDY; COLON; CYTOCHEMISTRY; DRUG MONITORING; INTESTINE MUCOSA; PATHOLOGY; PROCEDURES; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; YOUNG ADULT;

EID: 85021237082     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2017.02.016     Document Type: Article
Times cited : (160)

References (32)
  • 1
    • 33847179443 scopus 로고    scopus 로고
    • A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis
    • D'Haens, G., Sandborn, W.J., Feagan, B.G., et al. A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis. Gastroenterology 132 (2007), 763–786.
    • (2007) Gastroenterology , vol.132 , pp. 763-786
    • D'Haens, G.1    Sandborn, W.J.2    Feagan, B.G.3
  • 2
    • 84867027990 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel diseases: a systematic review
    • Neurath, M.F., Travis, S.P., Mucosal healing in inflammatory bowel diseases: a systematic review. Gut 61 (2012), 1619–1635.
    • (2012) Gut , vol.61 , pp. 1619-1635
    • Neurath, M.F.1    Travis, S.P.2
  • 3
    • 0001458414 scopus 로고
    • Biopsy studies in ulcerative colitis
    • Truelove, S.C., Richards, W.C., Biopsy studies in ulcerative colitis. Br Med J 1 (1956), 1315–1318.
    • (1956) Br Med J , vol.1 , pp. 1315-1318
    • Truelove, S.C.1    Richards, W.C.2
  • 4
    • 34547503869 scopus 로고    scopus 로고
    • Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort
    • Froslie, K.F., Jahnsen, J., Moum, B.A., et al. Mucosal healing in inflammatory bowel disease: results from a Norwegian population-based cohort. Gastroenterology 133 (2007), 412–422.
    • (2007) Gastroenterology , vol.133 , pp. 412-422
    • Froslie, K.F.1    Jahnsen, J.2    Moum, B.A.3
  • 5
    • 80053130407 scopus 로고    scopus 로고
    • Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis
    • Colombel, J.F., Rutgeerts, P., Reinisch, W., et al. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis. Gastroenterology 141 (2011), 1194–1201.
    • (2011) Gastroenterology , vol.141 , pp. 1194-1201
    • Colombel, J.F.1    Rutgeerts, P.2    Reinisch, W.3
  • 6
    • 70349418632 scopus 로고    scopus 로고
    • Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab
    • Sandborn, W.J., Rutgeerts, P., Feagan, B.G., et al. Colectomy rate comparison after treatment of ulcerative colitis with placebo or infliximab. Gastroenterology 137 (2009), 1250–1260.
    • (2009) Gastroenterology , vol.137 , pp. 1250-1260
    • Sandborn, W.J.1    Rutgeerts, P.2    Feagan, B.G.3
  • 7
    • 33947709456 scopus 로고    scopus 로고
    • The effects of infliximab therapy on health-related quality of life in ulcerative colitis patients
    • Feagan, B.G., Reinisch, W., Rutgeerts, P., et al. The effects of infliximab therapy on health-related quality of life in ulcerative colitis patients. Am J Gastroenterol 102 (2007), 794–802.
    • (2007) Am J Gastroenterol , vol.102 , pp. 794-802
    • Feagan, B.G.1    Reinisch, W.2    Rutgeerts, P.3
  • 8
    • 84941260661 scopus 로고    scopus 로고
    • Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): determining therapeutic goals for treat-to-target
    • Peyrin-Biroulet, L., Sandborn, W., Sands, B.E., et al. Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): determining therapeutic goals for treat-to-target. Am J Gastroenterol 110 (2015), 1324–1328.
    • (2015) Am J Gastroenterol , vol.110 , pp. 1324-1328
    • Peyrin-Biroulet, L.1    Sandborn, W.2    Sands, B.E.3
  • 9
    • 0026065160 scopus 로고
    • Microscopic activity in ulcerative colitis: what does it mean?
    • Riley, S.A., Mani, V., Goodman, M.J., et al. Microscopic activity in ulcerative colitis: what does it mean?. Gut 32 (1991), 174–178.
    • (1991) Gut , vol.32 , pp. 174-178
    • Riley, S.A.1    Mani, V.2    Goodman, M.J.3
  • 10
    • 84869487488 scopus 로고    scopus 로고
    • Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing
    • Bessissow, T., Lemmens, B., Ferrante, M., et al. Prognostic value of serologic and histologic markers on clinical relapse in ulcerative colitis patients with mucosal healing. Am J Gastroenterol 107 (2012), 1684–1692.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1684-1692
    • Bessissow, T.1    Lemmens, B.2    Ferrante, M.3
  • 11
    • 0035166741 scopus 로고    scopus 로고
    • Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis
    • Bitton, A., Peppercorn, M.A., Antonioli, D.A., et al. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology 120 (2001), 13–20.
    • (2001) Gastroenterology , vol.120 , pp. 13-20
    • Bitton, A.1    Peppercorn, M.A.2    Antonioli, D.A.3
  • 12
    • 84991038017 scopus 로고    scopus 로고
    • Histological disease activity as a predictor of clinical relapse among patients with ulcerative colitis: systematic review and meta-analysis
    • Park, S., Abdi, T., Gentry, M., et al. Histological disease activity as a predictor of clinical relapse among patients with ulcerative colitis: systematic review and meta-analysis. Am J Gastroenterol 111 (2016), 1692–1701.
    • (2016) Am J Gastroenterol , vol.111 , pp. 1692-1701
    • Park, S.1    Abdi, T.2    Gentry, M.3
  • 13
    • 84887997494 scopus 로고    scopus 로고
    • Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study
    • Rubin, D.T., Huo, D., Kinnucan, J.A., et al. Inflammation is an independent risk factor for colonic neoplasia in patients with ulcerative colitis: a case-control study. Clin Gastroenterol Hepatol 11 (2013), 1601–1608.
    • (2013) Clin Gastroenterol Hepatol , vol.11 , pp. 1601-1608
    • Rubin, D.T.1    Huo, D.2    Kinnucan, J.A.3
  • 14
    • 34848893583 scopus 로고    scopus 로고
    • Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study
    • Gupta, R.B., Harpaz, N., Itzkowitz, S., et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology 133 (2007), 1099–1105.
    • (2007) Gastroenterology , vol.133 , pp. 1099-1105
    • Gupta, R.B.1    Harpaz, N.2    Itzkowitz, S.3
  • 15
    • 64049090466 scopus 로고    scopus 로고
    • Severity of inflammation as a predictor of colectomy in patients with chronic ulcerative colitis
    • Hefti, M.M., Chessin, D.B., Harpaz, N.H., et al. Severity of inflammation as a predictor of colectomy in patients with chronic ulcerative colitis. Dis Colon Rectum 52 (2009), 193–197.
    • (2009) Dis Colon Rectum , vol.52 , pp. 193-197
    • Hefti, M.M.1    Chessin, D.B.2    Harpaz, N.H.3
  • 16
    • 84960425683 scopus 로고    scopus 로고
    • Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up
    • Bryant, R.V., Burger, D.C., Delo, J., et al. Beyond endoscopic mucosal healing in UC: histological remission better predicts corticosteroid use and hospitalisation over 6 years of follow-up. Gut 65 (2016), 408–414.
    • (2016) Gut , vol.65 , pp. 408-414
    • Bryant, R.V.1    Burger, D.C.2    Delo, J.3
  • 17
    • 84901231807 scopus 로고    scopus 로고
    • Histologic remission: the ultimate therapeutic goal in ulcerative colitis?
    • Peyrin–Biroulet, L., Bressenot, A., Kampman, W., Histologic remission: the ultimate therapeutic goal in ulcerative colitis?. Clin Gastroenterol Hepatol 12 (2014), 929–934.
    • (2014) Clin Gastroenterol Hepatol , vol.12 , pp. 929-934
    • Peyrin–Biroulet, L.1    Bressenot, A.2    Kampman, W.3
  • 18
    • 84879093785 scopus 로고    scopus 로고
    • Clinical implications of histologic abnormalities in colonic biopsy specimens from patients with ulcerative colitis in clinical remission
    • Feagins, L.A., Melton, S.D., Iqbal, R., et al. Clinical implications of histologic abnormalities in colonic biopsy specimens from patients with ulcerative colitis in clinical remission. Inflamm Bowel Dis 18 (2013), 1477–1482.
    • (2013) Inflamm Bowel Dis , vol.18 , pp. 1477-1482
    • Feagins, L.A.1    Melton, S.D.2    Iqbal, R.3
  • 19
    • 0033849872 scopus 로고    scopus 로고
    • A reproducible grading scale for histological assessment of inflammation in ulcerative colitis
    • Geboes, K., Riddell, R., Öst, A., et al. A reproducible grading scale for histological assessment of inflammation in ulcerative colitis. Gut 47 (2000), 404–409.
    • (2000) Gut , vol.47 , pp. 404-409
    • Geboes, K.1    Riddell, R.2    Öst, A.3
  • 20
    • 85019739430 scopus 로고    scopus 로고
    • Development and validation of the Nancy histological index for UC
    • Marchal-Bressenot, A., Salleron, J., Boulagnon-Rombi, C., et al. Development and validation of the Nancy histological index for UC. Gut 66 (2017), 43–49.
    • (2017) Gut , vol.66 , pp. 43-49
    • Marchal-Bressenot, A.1    Salleron, J.2    Boulagnon-Rombi, C.3
  • 21
    • 85025105106 scopus 로고    scopus 로고
    • Development and validation of a histological index for UC
    • Mosli, M.H., Feagan, B.G., Zou, G., et al. Development and validation of a histological index for UC. Gut 66 (2017), 50–58.
    • (2017) Gut , vol.66 , pp. 50-58
    • Mosli, M.H.1    Feagan, B.G.2    Zou, G.3
  • 22
    • 0027301716 scopus 로고
    • Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis
    • Odze, R., Antonioli, D., Peppercorn, M., et al. Effect of topical 5-aminosalicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis. Am J Surg Pathol 17 (1993), 869–875.
    • (1993) Am J Surg Pathol , vol.17 , pp. 869-875
    • Odze, R.1    Antonioli, D.2    Peppercorn, M.3
  • 23
    • 33646778482 scopus 로고    scopus 로고
    • The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications
    • Satsangi, J., Silverberg, M., Vermeire, S., et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 55 (2006), 749–753.
    • (2006) Gut , vol.55 , pp. 749-753
    • Satsangi, J.1    Silverberg, M.2    Vermeire, S.3
  • 24
    • 66949177978 scopus 로고    scopus 로고
    • Safety and efficacy of a new 3.3 g bid tablet formulation in patients with mild-to-moderately-active ulcerative colitis: a multicenter, randomized, double-blind, placebo- controlled study
    • Scherl, E.J., Pruitt, R., Gordon, G.L., et al. Safety and efficacy of a new 3.3 g bid tablet formulation in patients with mild-to-moderately-active ulcerative colitis: a multicenter, randomized, double-blind, placebo- controlled study. Am J Gastroenterol 104 (2009), 1452–1459.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1452-1459
    • Scherl, E.J.1    Pruitt, R.2    Gordon, G.L.3
  • 25
    • 0031812412 scopus 로고    scopus 로고
    • A simple clinical colitis activity index
    • Walmsley, R.S., Ayres, R.C., Pounder, R.E., et al. A simple clinical colitis activity index. Gut 43 (1998), 29–32.
    • (1998) Gut , vol.43 , pp. 29-32
    • Walmsley, R.S.1    Ayres, R.C.2    Pounder, R.E.3
  • 26
    • 0031880601 scopus 로고    scopus 로고
    • Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time
    • Kleer, C.G., Appelman, H.D., Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time. Am J Surg Pathol 22 (1998), 983–989.
    • (1998) Am J Surg Pathol , vol.22 , pp. 983-989
    • Kleer, C.G.1    Appelman, H.D.2
  • 27
    • 0029968599 scopus 로고    scopus 로고
    • Diagnostic difficulty arising from rectal recovery in ulcerative colitis
    • Levine, T.S., Tzardi, M., Mitchell, S., et al. Diagnostic difficulty arising from rectal recovery in ulcerative colitis. J Clin Pathol 49 (1996), 319–323.
    • (1996) J Clin Pathol , vol.49 , pp. 319-323
    • Levine, T.S.1    Tzardi, M.2    Mitchell, S.3
  • 28
    • 0029033343 scopus 로고
    • Patchiness of mucosal inflammation in treated ulcerative colitis: a prospective study
    • Bernstein, C.N., Shanahan, F., Anton, P.A., et al. Patchiness of mucosal inflammation in treated ulcerative colitis: a prospective study. Gastrointest Endosc 42 (1995), 232–237.
    • (1995) Gastrointest Endosc , vol.42 , pp. 232-237
    • Bernstein, C.N.1    Shanahan, F.2    Anton, P.A.3
  • 29
    • 67049137968 scopus 로고    scopus 로고
    • Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort
    • Solberg, I.C., Lygren, I., Jahnsen, J., et al. Clinical course during the first 10 years of ulcerative colitis: results from a population-based inception cohort. Scand J Gastroenterol 44 (2009), 431–440.
    • (2009) Scand J Gastroenterol , vol.44 , pp. 431-440
    • Solberg, I.C.1    Lygren, I.2    Jahnsen, J.3
  • 30
    • 85033449938 scopus 로고    scopus 로고
    • U.S. Department of Health and Human Services Food and Drug Adminstration Center for Drug Evaluation and Research (CDER). Ulcerative colitis: clinical trial endpoints guidance for industry. Available at: Accessed September 4
    • U.S. Department of Health and Human Services Food and Drug Adminstration Center for Drug Evaluation and Research (CDER). Ulcerative colitis: clinical trial endpoints guidance for industry. Available at: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm515143.pdf. Accessed September 4, 2016.
    • (2016)
  • 31
    • 85019753509 scopus 로고    scopus 로고
    • Assessment of the degree of variation of histologic inflammation in ulcerative colitis
    • S-232
    • Mikolajczyk, A.E., Watson, S., Ackerman, M.T., et al. Assessment of the degree of variation of histologic inflammation in ulcerative colitis. Gastroenterology, 146, 2014 S-232.
    • (2014) Gastroenterology , vol.146
    • Mikolajczyk, A.E.1    Watson, S.2    Ackerman, M.T.3
  • 32
    • 0027292761 scopus 로고
    • Mesalamine capsules for treatment of active ulcerative colitis: results of a controlled trial
    • Hanauer, S., Schwartz, J., Robinson, M., et al. Mesalamine capsules for treatment of active ulcerative colitis: results of a controlled trial. Am J Gastroenterol 88 (1993), 1188–1197.
    • (1993) Am J Gastroenterol , vol.88 , pp. 1188-1197
    • Hanauer, S.1    Schwartz, J.2    Robinson, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.