In vivo immune signatures of healthy human pregnancy: Inherently inflammatory or anti-inflammatory?

PLoS ONE

Volumn 12, Issue 6, 2017, Pages

  Graham, Caroline ^a   Chooniedass, Rishma ^a   Stefura, William P ^a   Becker, A B ^a   Sears, M R ^g   Turvey, S E ⁱ   Mandhane, Piush J ^e   Subbarao, P ^f   HayGlass, Kent T ^a,b   Allen, R ^h   Anand, S S ^g   Befus, A D ^e   Brauer, M ⁱ   Brook, J R ^j   Chen, E ^k   Cyr, M ^g   Daley, D ⁱ   Dell, S ^l   Denburg, J A ^g   Elliott, S ^m   Grasemann, H ^l   Hay Glass, K ^a   Hegele, R ^l   Holness, D L ^j   Lou, W Y W ^j   Kobor, M S ⁱ   Kollman, T R ⁱ   Kozyrskyj, A A ^e   Laprise, C ⁿ   Larche, M ^g   Macri, J ^g   Mandhane, P M ^e   Miller, G ^k   Moqbel, R ^a   Moraes, T ^l   Pare, P D ⁱ   Ramsey, C ^a   Ratjen, F ^l   Sandford, A ⁱ   Scott, J A ^j   Silverman, F ^j   Takaro, T ^h   Tang, P ⁱ   Tebbutt, S ⁱ   To, T ^l   more..

^a UNIVERSITY OF MANITOBA   (Canada)

^b CHILDREN S HOSPITAL RESEARCH INSTITUTE OF MANITOBA   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e UNIVERSITY OF ALBERTA   (Canada)

^f HOSPITAL FOR SICK CHILDREN   (Canada)

^g MCMASTER UNIVERSITY   (Canada)

^h SIMON FRASER UNIVERSITY   (Canada)

ⁱ UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

^k NORTHWESTERN UNIVERSITY   (United States)

^l Sick Children Hospital   (Canada)

^m UNIVERSITY OF WATERLOO   (Canada)

ⁿ UNIVERSITÉ DU QUÉBEC À CHICOUTIMI   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 18; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; ANTIINFLAMMATORY AGENT; AUTACOID; BIOLOGICAL MARKER;

ADULT; ARTICLE; FEMALE; GESTATIONAL AGE; HUMAN; IN VIVO STUDY; INFLAMMATION; INNATE IMMUNITY; LONGITUDINAL STUDY; NORMAL HUMAN; PREGNANCY; PROTEIN EXPRESSION; PUERPERIUM; ADOLESCENT; CANADA; IMMUNOLOGY; KINETICS; METABOLISM; PATHOLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; ANTI-INFLAMMATORY AGENTS; BIOMARKERS; CANADA; FEMALE; GESTATIONAL AGE; HUMANS; IMMUNITY, INNATE; INFLAMMATION; INFLAMMATION MEDIATORS; KINETICS; LONGITUDINAL STUDIES; PREGNANCY; YOUNG ADULT;

EID: 85021228037     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0177813     Document Type: Article

References (93)

1. Chaouat G, Tranchot Diallo J, Volumenie JL, Menu E, Gras G, Delage G, et al. Immune suppression and Th1/Th2 balance in pregnancy revisited: a (very) personal tribute to Tom Wegmann. Am J Reprod Immunol. 1997 Jun; 37(6):427-34. PMID: 9228297
2. St Louis D, Romero R, Plazyo O, Arenas-Hernandez M, Panaitescu B, Xu Y, et al. Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone. J Immunol. 2016 Feb 01; 196(3):1044-59. https://doi.org/10.4049/jimmunol.1501962 PMID: 26740111
3. PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, et al. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol. 2015 Apr; 16(4):328-34. https://doi.org/10.1038/ni.3131 PMID: 25789673
4. Svensson-Arvelund J, Mehta RB, Lindau R, Mirrasekhian E, Rodriguez-Martinez H, Berg G, et al. The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages. J Immunol. 2015 Feb 15; 194(4):1534-44. https://doi.org/10.4049/jimmunol.1401536 PMID: 25560409
5. Baylis F. Pregnant women deserve better. Nature. 2010 Jun 10; 465(7299):689-90. https://doi.org/10.1038/465689a PMID: 20535185
6. Catalano PW, MA. Wise, PH. Bianchi, DW. Saade, GR. Scientific Vision Workshop on Pregnancy and Pregnancy Outcomes. Bethesa, Maryland2011 [updated 2011; cited 2016 02/18/2016]; https://www.nichd.nih.gov/vision/vision-themes/pregnancy/Documents/Vision-Pregnancy-WP-042811.pdf.
7. Foulkes MA, Grady C, Spong CY, Bates A, Clayton JA. Clinical research enrolling pregnant women: a workshop summary. J Womens Health (Larchmt). 2011 Oct; 20(10):1429-32.
8. Heyborne KS, R M. Reproductive Immunology. Bronson RA, N J. Anderson D. Branch DW. Kutteh WH., editor. Cambridge: Blackwell Science; 1996.
9. Huang E, Wells CA. The ground state of innate immune responsiveness is determined at the interface of genetic, epigenetic, and environmental influences. J Immunol. 2014 Jul 1; 193(1):13-9. https://doi.org/10.4049/jimmunol.1303410 PMID: 24951823
10. Gonzalez-Perez G, Hicks AL, Tekieli TM, Radens CM, Williams BL, Lamouse-Smith ES. Maternal Antibiotic Treatment Impacts Development of the Neonatal Intestinal Microbiome and Antiviral Immunity. J Immunol. 2016 May 01; 196(9):3768-79. https://doi.org/10.4049/jimmunol.1502322 PMID: 27036912
11. Mendola P, Wallace M, Hwang BS, Liu D, Robledo C, Mannisto T, et al. Preterm birth and air pollution: Critical windows of exposure for women with asthma. J Allergy Clin Immunol. 2016 Aug; 138(2):432-40 e5. https://doi.org/10.1016/j.jaci.2015.12.1309 PMID: 26944405
12. von Mutius E, Martinez FD. Inconclusive Results of Randomized Trials of Prenatal Vitamin D for Asthma Prevention in Offspring: Curbing the Enthusiasm. JAMA. 2016 Jan 26; 315(4):347-8. https://doi.org/10.1001/jama.2015.18963 PMID: 26813205
13. Tyrrell J, Richmond RC, Palmer TM, Feenstra B, Rangarajan J, Metrustry S, et al. Genetic Evidence for Causal Relationships Between Maternal Obesity-Related Traits and Birth Weight. JAMA. 2016 Mar 15; 315(11):1129-40. https://doi.org/10.1001/jama.2016.1975 PMID: 26978208
14. Aagaard-Tillery KM, Silver R, Dalton J. Immunology of normal pregnancy. Semin Fetal Neonatal Med. 2006 Oct; 11(5):279-95. https://doi.org/10.1016/j.siny.2006.04.003 PMID: 16784908
15. Visser N, van Rijn BB, Rijkers GT, Franx A, Bruinse HW. Inflammatory changes in preeclampsia: current understanding of the maternal innate and adaptive immune response. Obstet Gynecol Surv. 2007 Mar; 62(3):191-201. https://doi.org/10.1097/01.ogx.0000256779.06275.c4 PMID: 17306041
16. Aye IL, Lager S, Ramirez VI, Gaccioli F, Dudley DJ, Jansson T, et al. Increasing maternal body mass index is associated with systemic inflammation in the mother and the activation of distinct placental inflammatory pathways. Biol Reprod. 2014 Jun; 90(6):129. https://doi.org/10.1095/biolreprod.113.116186 PMID: 24759787
17. Chawes BL, Stokholm J, Bonnelykke K, Brix S, Bisgaard H. Neonates with reduced neonatal lung function have systemic low-grade inflammation. J Allergy Clin Immunol. 2015 Jun; 135(6):1450-6 e1. https://doi.org/10.1016/j.jaci.2014.11.020 PMID: 25579483
18. Subbarao P, Anand SS, Becker AB, Befus AD, Brauer M, Brook JR, et al. The Canadian Healthy Infant Longitudinal Development (CHILD) Study: examining developmental origins of allergy and asthma. Thorax. 2015 Oct; 70(10):998-1000. https://doi.org/10.1136/thoraxjnl-2015-207246 PMID: 26069286
19. Moraes TJ, Lefebvre DL, Chooniedass R, Becker AB, Brook JR, Denburg J, et al. The Canadian healthy infant longitudinal development birth cohort study: biological samples and biobanking. Paediatr Perinat Epidemiol. 2015 Jan; 29(1):84-92. https://doi.org/10.1111/ppe.12161 PMID: 25405552
20. Pendeloski KP, Ono E, Torloni MR, Mattar R, Daher S. Maternal obesity and inflammatory mediators: A controversial association. Am J Reprod Immunol. 2017 Mar 22;
21. Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26; 91(9):3652-6. PMID: 8170963
22. Xu LL, Warren MK, Rose WL, Gong W, Wang JM. Human recombinant monocyte chemotactic protein and other C-C chemokines bind and induce directional migration of dendritic cells in vitro. J Leukoc Biol. 1996 Sep; 60(3):365-71. PMID: 8830793
23. Lam VC, Lanier LL. NK cells in host responses to viral infections. Curr Opin Immunol. 2016 Dec 13;4443-51.
24. Xia M, Sui Z. Recent developments in CCR2 antagonists. Expert Opin Ther Pat. 2009 Mar; 19(3):295-303. https://doi.org/10.1517/13543770902755129 PMID: 19441905
25. O'Connor T, Borsig L, Heikenwalder M. CCL2-CCR2 Signaling in Disease Pathogenesis. Endocr Metab Immune Disord Drug Targets. 2015 15(2):105-18. PMID: 25772168
26. Hedges JC, Singer CA, Gerthoffer WT. Mitogen-activated protein kinases regulate cytokine gene expression in human airway myocytes. Am J Respir Cell Mol Biol. 2000 Jul; 23(1):86-94. https://doi.org/10.1165/ajrcmb.23.1.4014 PMID: 10873157
27. Harada A, Sekido N, Akahoshi T, Wada T, Mukaida N, Matsushima K. Essential involvement of interleukin-8 (IL-8) in acute inflammation. J Leukoc Biol. 1994 Nov; 56(5):559-64. PMID: 7964163
28. Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest. 1989 Oct; 84(4):1045-9. https://doi.org/10.1172/JCI114265 PMID: 2677047
29. Hosoki K, Itazawa T, Boldogh I, Sur S. Neutrophil recruitment by allergens contribute to allergic sensitization and allergic inflammation. Curr Opin Allergy Clin Immunol. 2016 Feb; 16(1):45-50. https://doi.org/10.1097/ACI.0000000000000231 PMID: 26694038
30. Tan SY, Weninger W. Neutrophil migration in inflammation: intercellular signal relay and crosstalk. Curr Opin Immunol. 2016 Dec 09;4434-42.
31. Luster AD, Unkeless JC, Ravetch JV. Gamma-interferon transcriptionally regulates an early-response gene containing homology to platelet proteins. Nature. 1985 Jun 20-26; 315(6021):672-6. PMID: 3925348
32. Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, Luster AD. IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol. 2002 Apr 01; 168(7):3195-204. PMID: 11907072
33. Angiolillo AL, Sgadari C, Taub DD, Liao F, Farber JM, Maheshwari S, et al. Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo. J Exp Med. 1995 Jul 01; 182(1):155-62. PMID: 7540647
34. Campbell JD, Gangur V, Simons FE, HayGlass KT. Allergic humans are hyporesponsive to a CXCR3 ligand-mediated Th1 immunity-promoting loop. FASEB J. 2004 Feb; 18(2):329-31. https://doi.org/10.1096/fj.02-0908fje PMID: 14657006
35. Hamidzadeh K, Christensen SM, Dalby E, Chandrasekaran P, Mosser DM. Macrophages and the Recovery from Acute and Chronic Inflammation. Annu Rev Physiol. 2017 Feb 10;79567-92.
36. Hunter CA, Jones SA. IL-6 as a keystone cytokine in health and disease. Nat Immunol. 2015 May; 16 (5):448-57. https://doi.org/10.1038/ni.3153 PMID: 25898198
37. van der Poll T, Keogh CV, Guirao X, Buurman WA, Kopf M, Lowry SF. Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia. J Infect Dis. 1997 Aug; 176(2):439-44. PMID: 9237710
38. Kristiansen OP, Mandrup-Poulsen T. Interleukin-6 and diabetes: the good, the bad, or the indifferent? Diabetes. 2005 Dec; 54 Suppl 2S114-24.
39. Dubinski A, Zdrojewicz Z. [The role of interleukin-6 in development and progression of atherosclerosis]. Pol Merkur Lekarski. 2007 Apr; 22(130):291-4. PMID: 17684929
40. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry. 2010 Mar 01; 67(5):446-57. https://doi.org/10.1016/j.biopsych.2009.09.033 PMID: 20015486
41. Swardfager W, Lanctot K, Rothenburg L, Wong A, Cappell J, Herrmann N. A meta-analysis of cytokines in Alzheimer's disease. Biol Psychiatry. 2010 Nov 15; 68(10):930-41. https://doi.org/10.1016/j.biopsych.2010.06.012 PMID: 20692646
42. Tackey E, Lipsky PE, Illei GG. Rationale for interleukin-6 blockade in systemic lupus erythematosus. Lupus. 2004 13(5):339-43. https://doi.org/10.1191/0961203304lu1023oa PMID: 15230289
43. Gado K, Domjan G, Hegyesi H, Falus A. Role of INTERLEUKIN-6 in the pathogenesis of multiple myeloma. Cell Biol Int. 2000 24(4):195-209. https://doi.org/10.1006/cbir.2000.0497 PMID: 10816321
44. Smith PC, Hobisch A, Lin DL, Culig Z, Keller ET. Interleukin-6 and prostate cancer progression. Cytokine Growth Factor Rev. 2001 Mar; 12(1):33-40. PMID: 11312117
45. Nishimoto N. Interleukin-6 in rheumatoid arthritis. Curr Opin Rheumatol. 2006 May; 18(3):277-81. https://doi.org/10.1097/01.bor.0000218949.19860.d1 PMID: 16582692
46. Banchereau J, Pascual V, O'Garra A. From IL-2 to IL-37: the expanding spectrum of anti-inflammatory cytokines. Nat Immunol. 2012 Oct; 13(10):925-31. https://doi.org/10.1038/ni.2406 PMID: 22990890
47. Gabrysova L, Howes A, Saraiva M, O'Garra A. The regulation of IL-10 expression. Curr Top Microbiol Immunol. 2014 380157-90.
48. Mosser DM, Zhang X. Interleukin-10: new perspectives on an old cytokine. Immunol Rev. 2008 Dec;226205-18.
49. Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB. Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 2004 22929-79.
50. Saraiva M, O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol. 2010 Mar; 10(3):170-81. https://doi.org/10.1038/nri2711 PMID: 20154735
51. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991 Nov 01; 174(5):1209-20. PMID: 1940799
52. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001 19683-765.
53. Dinarello CA, Novick D, Kim S, Kaplanski G. Interleukin-18 and IL-18 binding protein. Front Immunol. 2013 Oct 08;4289.
54. Banchereau R, Cepika AM, Banchereau J, Pascual V. Understanding Human Autoimmunity and Autoinflammation Through Transcriptomics. Annu Rev Immunol. 2017 Jan 30
55. Sutinen EM, Pirttila T, Anderson G, Salminen A, Ojala JO. Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-beta production in human neuron-like cells. J Neuroinflammation. 2012 Aug 16;9199.
56. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995 Nov 02; 378(6552):88-91. https://doi.org/10.1038/378088a0 PMID: 7477296
57. Liu Z, Wang H, Xiao W, Wang C, Liu G, Hong T. Thyrocyte interleukin-18 expression is up-regulated by interferon-gamma and may contribute to thyroid destruction in Hashimoto's thyroiditis. Int J Exp Pathol. 2010 Oct; 91(5):420-5. https://doi.org/10.1111/j.1365-2613.2010.00715.x PMID: 20586818
58. Perrier S, Darakhshan F, Hajduch E. IL-1 receptor antagonist in metabolic diseases: Dr Jekyll or Mr Hyde? FEBS Lett. 2006 Nov 27; 580(27):6289-94. https://doi.org/10.1016/j.febslet.2006.10.061 PMID: 17097645
59. Di Paolo NC, Shayakhmetov DM. Interleukin 1alpha and the inflammatory process. Nat Immunol. 2016 Jul 19; 17(8):906-13. https://doi.org/10.1038/ni.3503 PMID: 27434011
60. Ito Y, Kaneko N, Iwasaki T, Morikawa S, Kaneko K, Masumoto J. IL-1 as a target in inflammation. Endocr Metab Immune Disord Drug Targets. 2015 15(3):206-11. PMID: 26333726
61. Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994 Dec; 8(15):1314-25. PMID: 8001745
62. El-Omar EM, Carrington M, Chow WH, McColl KE, Bream JH, Young HA, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000 Mar 23; 404(6776):398-402. https://doi.org/10.1038/35006081 PMID: 10746728
63. Aksentijevich I, Masters SL, Ferguson PJ, Dancey P, Frenkel J, van Royen-Kerkhoff A, et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med. 2009 Jun 04; 360(23):2426-37. https://doi.org/10.1056/NEJMoa0807865 PMID: 19494218
64. Willrich MA, Murray DL, Snyder MR. Tumor necrosis factor inhibitors: clinical utility in autoimmune diseases. Transl Res. 2015 Feb; 165(2):270-82. https://doi.org/10.1016/j.trsl.2014.09.006 PMID: 25305470
65. Ware CF, Santee S, Glass A. Tumor necrosis factor-related ligands and receptors. In:Thomson A, editor. The Cytokine Handbook. Third ed. San Diego, CA: Academic Press; 1998. p. 549-92.
66. Wei M, Kuukasjarvi P, Laurikka J, Pehkonen E, Kaukinen S, Laine S, et al. Inflammatory cytokines and soluble receptors after coronary artery bypass grafting. Cytokine. 2001 Aug 21; 15(4):223-8. https://doi.org/10.1006/cyto.2001.0920 PMID: 11563882
67. Locksley RM, Killeen N, Lenardo MJ. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 2001 Feb 23; 104(4):487-501. PMID: 11239407
68. Baxter AE, Kaufmann DE. Tumor-necrosis factor is a master of T cell exhaustion. Nat Immunol. 2016 May; 17(5):476-8. https://doi.org/10.1038/ni.3436 PMID: 27092797
69. Green WD, Beck MA. Obesity altered T cell metabolism and the response to infection. Curr Opin Immunol. 2017 Mar 27;461-7.
70. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF 3rd, Petraglia F. Inflammation and pregnancy. Reprod Sci. 2009 Feb; 16(2):206-15. https://doi.org/10.1177/1933719108329095 PMID: 19208789
71. Sacks G, Sargent I, Redman C. An innate view of human pregnancy. Immunol Today. 1999 Mar; 20 (3):114-8. PMID: 10203701
72. Sacks GP, Studena K, Sargent K, Redman CW. Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis. Am J Obstet Gynecol. 1998 Jul; 179(1):80-6. PMID: 9704769
73. Blank V, Hirsch E, Challis JR, Romero R, Lye SJ. Cytokine signaling, inflammation, innate immunity and preterm labour - a workshop report. Placenta. 2008 Mar; 29 Suppl AS102-4.
74. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science. 1998 Aug 21; 281(5380):1191-3. PMID: 9712583
75. Chatterjee P, Chiasson VL, Bounds KR, Mitchell BM. Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy. Front Immunol. 2014 5253.
76. Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, et al. Peripheral blood cytokine profiling during pregnancy and post-partum periods. Am J Reprod Immunol. 2010 Dec; 64(6):411-26. https://doi.org/10.1111/j.1600-0897.2010.00889.x PMID: 20712812
77. Bjorkander S, Bremme K, Persson JO, van Vollenhoven RF, Sverremark-Ekstrom E, Holmlund U. Pregnancy-associated inflammatory markers are elevated in pregnant women with systemic lupus erythematosus. Cytokine. 2012 Aug; 59(2):392-9. https://doi.org/10.1016/j.cyto.2012.04.046 PMID: 22633082
78. Szarka A, Rigo J Jr., Lazar L, Beko G, Molvarec A. Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol. 2010 1159.
79. Johnstone FD, Thong KJ, Bird AG, Whitelaw J. Lymphocyte subpopulations in early human pregnancy. Obstet Gynecol. 1994 Jun; 83(6):941-6. PMID: 8190436
80. Campbell JD, Stinson MJ, Simons FE, Rector ES, HayGlass KT. In vivo stability of human chemokine and chemokine receptor expression. Hum Immunol. 2001 Jul; 62(7):668-78. PMID: 11423172
81. Chaouat G, Assal Meliani A, Martal J, Raghupathy R, Elliott JF, Mosmann T, et al. IL-10 prevents naturally occurring fetal loss in the CBA x DBA/2 mating combination, and local defect in IL-10 production in this abortion-prone combination is corrected by in vivo injection of IFN-tau. J Immunol. 1995 May 01; 154(9):4261-8. PMID: 7722286
82. Thaxton JE, Sharma S. Interleukin-10: a multi-faceted agent of pregnancy. Am J Reprod Immunol. 2010 Jun; 63(6):482-91. https://doi.org/10.1111/j.1600-0897.2010.00810.x PMID: 20163400
83. Belo L, Santos-Silva A, Rocha S, Caslake M, Cooney J, Pereira-Leite L, et al. Fluctuations in C-reactive protein concentration and neutrophil activation during normal human pregnancy. Eur J Obstet Gynecol Reprod Biol. 2005 Nov 01; 123(1):46-51. https://doi.org/10.1016/j.ejogrb.2005.02.022 PMID: 16260340
84. Miller EM. Changes in serum immunity during pregnancy. Am J Hum Biol. 2009 May-Jun; 21(3):401-3. https://doi.org/10.1002/ajhb.20882 PMID: 19189417
85. Perucci LO, Carneiro FS, Ferreira CN, Sugimoto MA, Soriani FM, Martins GG, et al. Annexin A1 Is Increased in the Plasma of Preeclamptic Women. PLoS One. 2015 10(9):e0138475. https://doi.org/10.1371/journal.pone.0138475 PMID: 26398190
86. McDade TW, Borja JB, Largado F, Adair LS, Kuzawa CW. Adiposity and Chronic Inflammation in Young Women Predict Inflammation during Normal Pregnancy in the Philippines. J Nutr. 2016 Feb; 146(2):353-7. https://doi.org/10.3945/jn.115.224279 PMID: 26764318
87. Romem Y, Artal R. C-reactive protein in pregnancy and in the postpartum period. Am J Obstet Gynecol. 1985 Feb 01; 151(3):380-3. PMID: 3970105
88. Rebelo F, Schlussel MM, Vaz JS, Franco-Sena AB, Pinto TJ, Bastos FI, et al. C-reactive protein and later preeclampsia: systematic review and meta-analysis taking into account the weight status. J Hypertens. 2013 Jan; 31(1):16-26. https://doi.org/10.1097/HJH.0b013e32835b0556 PMID: 23188419
89. Christian LM, Porter K. Longitudinal changes in serum proinflammatory markers across pregnancy and postpartum: effects of maternal body mass index. Cytokine. 2014 Dec; 70(2):134-40. https://doi.org/10.1016/j.cyto.2014.06.018 PMID: 25082648
90. Friis CM, Paasche Roland MC, Godang K, Ueland T, Tanbo T, Bollerslev J, et al. Adiposity-related inflammation: effects of pregnancy. Obesity (Silver Spring). 2013 Jan; 21(1):E124-30.
91. Stewart FM, Freeman DJ, Ramsay JE, Greer IA, Caslake M, Ferrell WR. Longitudinal assessment of maternal endothelial function and markers of inflammation and placental function throughout pregnancy in lean and obese mothers. J Clin Endocrinol Metab. 2007 Mar; 92(3):969-75. https://doi.org/10.1210/jc.2006-2083 PMID: 17192290
92. Simavli S, Derbent AU, Uysal S, Turhan NO. Hepcidin, iron status, and inflammation variables among healthy pregnant women in the Turkish population. J Matern Fetal Neonatal Med. 2014 Jan; 27(1):75-9. https://doi.org/10.3109/14767058.2013.804054 PMID: 23662610
93. NICHD. Pregnancy: For Researchers and Health Care Practitioners 2013; https://www.nichd.nih.gov/health/topics/pregnancy/resources/Pages/providers.aspx.