The Effect of Clopidogrel on the Response to Ischemia Reperfusion: A Human Study

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 22, Issue 4, 2017, Pages 368-373

  Kwong, Wilson ^a,b   Parker, John D ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

clopidogrel; endothelium; ischemia reperfusion; preconditioning

Indexed keywords

CLOPIDOGREL; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; PLACEBO; RANTES; ANTITHROMBOCYTIC AGENT; AUTACOID; BIOLOGICAL MARKER; CCL5 PROTEIN, HUMAN; ICAM1 PROTEIN, HUMAN; IL6 PROTEIN, HUMAN; TICLOPIDINE;

ADULT; ARTERY DIAMETER; ARTERY DILATATION; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; FLOW-MEDIATED DILATION TEST; HEART RATE; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PROTECTION; RADIAL ARTERY; REPERFUSION INJURY; SINGLE DRUG DOSE; ADOLESCENT; ANALOGS AND DERIVATIVES; BLOOD; BLOOD FLOW; DIAGNOSTIC IMAGING; DOPPLER ULTRASONOGRAPHY; DRUG EFFECTS; FEMALE; METABOLISM; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; TIME FACTOR; UPPER LIMB; VASCULAR ENDOTHELIUM; VASCULARIZATION; VASODILATATION; YOUNG ADULT;

ADOLESCENT; ADULT; BIOMARKERS; CHEMOKINE CCL5; ENDOTHELIUM, VASCULAR; FEMALE; HEALTHY VOLUNTEERS; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MALE; PLATELET AGGREGATION INHIBITORS; RADIAL ARTERY; REGIONAL BLOOD FLOW; REPERFUSION INJURY; TICLOPIDINE; TIME FACTORS; ULTRASONOGRAPHY, DOPPLER; UPPER EXTREMITY; VASODILATION; YOUNG ADULT;

EID: 85020486036     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248416683047     Document Type: Article

References (30)

1. Murry CE, Jennings RB, Reimer KA,. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986; 74 (5): 1124-1136.
2. Yellon DM, Hausenloy DJ,. Myocardial reperfusion injury. N Engl J Med. 2007; 357 (11): 1121-1135.
3. 111In-labeled platelet accumulation in infarcted myocardium. J Cardiovasc Pharmacol. 1985; 7 (5): 906-912.
4. Chintala MS, Bernardino V, Chiu PJ,. Cyclic GMP but not cyclic AMP prevents renal platelet accumulation after ischemia-reperfusion in anesthetized rats. J Pharmacol Exp Ther. 1994; 271 (3): 1203-1208.
5. Mirabet M, Garcia-Dorado D, Inserte J, et al. Platelets activated by transient coronary occlusion exacerbate ischemia-reperfusion injury in rat hearts. Am J Physiol Heart Circ Physiol. 2002; 283 (3): H1134-H1141.
6. Shimada Y, Kutsumi Y, Nishio H, et al. Role of platelets in myocardial ischemia-reperfusion injury in dogs. Jpn Circ J. 1997; 61 (3): 241-248.
7. Linden MD, Whittaker P, Frelinger AL III, Barnard MR, Michelson AD, Przyklenk K,. Preconditioning ischemia attenuates molecular indices of platelet activation-aggregation. J Thromb Haemost. 2006; 4 (12): 2670-2677.
8. Hata K, Whittaker P, Kloner RA, Przyklenk K,. Brief antecedent ischemia attenuates platelet-mediated thrombosis in damaged and stenotic canine coronary arteries: role of adenosine. Circulation. 1998; 97 (7): 692-702.
9. Kanko M, Maral H, Akbas MH, et al. Protective effects of clopidogrel on oxidant damage in a rat model of acute ischemia. Tohoku J Exp Med. 2005; 205 (2): 133-139.
10. Kanko M, Ozden M, Maral H, Acil C,. Effect of clopidogrel on nitric oxide levels in an ischemia reperfusion model. J Cardiovasc Pharmacol. 2006; 48 (1): 797-801.
11. 12 blockers confer direct postconditioning-like protection in reperfused rabbit hearts. J Cardiovasc Pharmacol Ther. 2013; 18 (3): 251-262.
12. Liuni A, Luca MC, Gori T, Parker JD,. Rosuvastatin prevents conduit artery endothelial dysfunction induced by ischemia and reperfusion by a cyclooxygenase-2-dependent mechanism. J Am Coll Cardiol. 2010; 55 (10): 1002-1006.
13. Luca MC, Liuni A, DiFabio J, Gori T, Parker JD,. The acute administration of either amiloride or captopril does not prevent endothelial dysfunction induced by ischemia and reperfusion in the human forearm vasculature. Can J Physiol Pharmacol. 2010; 88 (10): 996-1001.
14. Dragoni S, Di Stolfo G, Sicuro S, et al. Postconditioning fails to prevent radial artery endothelial dysfunction induced by ischemia and reperfusion: evidence from a human in vivo study. Can J Physiol Pharmacol. 2006; 84 (6): 611-615.
15. Gori T, Dragoni S, Lisi M, et al. Conduit artery constriction mediated by low flow a novel noninvasive method for the assessment of vascular function. J Am Coll Cardiol. 2008; 51 (20): 1953-1958.
16. Radegran G, Saltin B,. Nitric oxide in the regulation of vasomotor tone in human skeletal muscle. Am J Physiol. 1999; 276 (6 pt 2): H1951-H1960.
17. Gori T, Sicuro S, Dragoni S, Donati G, Forconi S, Parker JD,. Sildenafil prevents endothelial dysfunction induced by ischemia and reperfusion via opening of adenosine triphosphate-sensitive potassium channels: a human in vivo study. Circulation. 2005; 111 (6): 742-746.
18. Wiviott SD, Steg PG,. Clinical evidence for oral antiplatelet therapy in acute coronary syndromes. Lancet. 2015; 386 (9990): 292-302.
19. Barrabes JA, Inserte J, Mirabet M, et al. Antagonism of P2Y12 or GPIIb/IIIa receptors reduces platelet-mediated myocardial injury after ischaemia and reperfusion in isolated rat hearts. Thromb Haemost. 2010; 104 (1): 128-135.
20. Roubille F, Lairez O, Mewton N, et al. Cardioprotection by clopidogrel in acute ST-elevated myocardial infarction patients: a retrospective analysis. Basic Res Cardiol. 2012; 107 (4): 275.
21. Nanhwan MK, Ling S, Kodakandla M, Nylander S, Ye Y, Birnbaum Y,. Chronic treatment with ticagrelor limits myocardial infarct size: an adenosine and cyclooxygenase-2-dependent effect. Arterioscler Thromb Vasc Biol. 2014; 34 (9): 2078-2085.
22. Ye Y, Birnbaum GD, Perez-Polo JR, Nanhwan MK, Nylander S, Birnbaum Y,. Ticagrelor protects the heart against reperfusion injury and improves remodeling after myocardial infarction. Arterioscler Thromb Vasc Biol. 2015; 35 (8): 1805-1814.
23. Heitzer T, Rudolph V, Schwedhelm E, et al. Clopidogrel improves systemic endothelial nitric oxide bioavailability in patients with coronary artery disease: evidence for antioxidant and antiinflammatory effects. Arterioscler Thromb Vasc Biol. 2006; 26 (7): 1648-1652.
24. Warnholtz A, Ostad MA, Velich N, et al. A single loading dose of clopidogrel causes dose-dependent improvement of endothelial dysfunction in patients with stable coronary artery disease: results of a double-blind, randomized study. Atherosclerosis. 2008; 196 (2): 689-695.
25. Neri M, Fineschi V, Di Paolo M, et al. Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction. Curr Vasc Pharmacol. 2015; 13 (1): 26-36.
26. Frangogiannis NG, Smith CW, Entman ML,. The inflammatory response in myocardial infarction. Cardiovasc Res. 2002; 53 (1): 31-47.
27. Braunersreuther V, Pellieux C, Pelli G, et al. Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice. J Mol Cell Cardiol. 2010; 48 (4): 789-798.
28. Harding SA, Sarma J, Din JN, Maciocia PM, Newby DE, Fox KA,. Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus. Heart. 2006; 92 (9): 1335-1337.
29. Azar RR, Kassab R, Zoghbi A, et al. Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease. Am Heart J. 2006; 151 (2): 521.e1-e521.e4.
30. Hu H, Batteux F, Chereau C, et al. Clopidogrel protects from cell apoptosis and oxidative damage in a mouse model of renal ischaemia-reperfusion injury. J Pathol. 2011; 225 (2): 265-275.