메뉴 건너뛰기




Volumn 32, Issue 3, 2016, Pages 178-183

Treatment of metastatic colorectal cancer: Standard of care and future perspectives

Author keywords

BRAF mutation; Metastatic colorectal cancer; Palliative chemotherapy; RAS mutation

Indexed keywords

AFLIBERCEPT; B RAF KINASE; BEVACIZUMAB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; PANITUMUMAB; RAMUCIRUMAB; REGORAFENIB; TUMOR MARKER;

EID: 85020213768     PISSN: 22974725     EISSN: 2297475X     Source Type: Journal    
DOI: 10.1159/000446052     Document Type: Review
Times cited : (30)

References (48)
  • 1
    • 85081592544 scopus 로고    scopus 로고
    • Gesellschaft der epidemi-ologischen Krebsregister
    • Robert Koch-Institut (Hrsg), Deutschland e.V. (Hrsg): ed 10. Berlin
    • Robert Koch-Institut (Hrsg), Gesellschaft der epidemi-ologischen Krebsregister in Deutschland e.V. (Hrsg): Krebs in Deutschland 2011/2012, ed 10. Berlin, 2015.
    • (2015) Krebs in Deutschland 2011/2012
  • 2
    • 0025998245 scopus 로고
    • Chemotherapy of advanced cancer of the colon and rectum
    • Bruckner HW, Motwani BT: Chemotherapy of advanced cancer of the colon and rectum. Semin Oncol 1991;18:443-461.
    • (1991) Semin Oncol , vol.18 , pp. 443-461
    • Bruckner, H.W.1    Motwani, B.T.2
  • 3
    • 6944230093 scopus 로고    scopus 로고
    • Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
    • O'Connell JB, Maggard MA, Ko CY: Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 2004; 96:1420-1425.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1420-1425
    • O'Connell, J.B.1    Maggard, M.A.2    Ko, C.Y.3
  • 4
    • 84893750035 scopus 로고    scopus 로고
    • Chemotherapy of metastatic colorectal cancer (article in German)
    • Modest DP, Hiddemann W, Heinemann V: Chemotherapy of metastatic colorectal cancer (article in German). Internist (Berl) 2014;55:37-42.
    • (2014) Internist (berl) , vol.55 , pp. 37-42
    • Modest, D.P.1    Hiddemann, W.2    Heinemann, V.3
  • 6
    • 84911474269 scopus 로고    scopus 로고
    • Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
    • Van Cutsem E, Cervantes A, Nordlinger B, Arnold D: Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2014;25(suppl 3):iii1-9.
    • (2014) Ann Oncol , vol.25 , pp. iii1-iii9
    • Van Cutsem, E.1    Cervantes, A.2    Nordlinger, B.3    Arnold, D.4
  • 11
    • 84875727313 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab-based combination regimens in patients with previously untreated metastatic colorectal cancer: Final results from a randomised phase II study of bevacizumab plus 5-fluorouracil, leucovorin plus irinotecan versus bevacizumab plus capecitabine plus irinotecan (FNCLCC ACCORD 13/0503 study)
    • Ducreux M, Adenis A, Pignon JP, Francois E, Chauffert B, Ichante JL, Boucher E, Ychou M, Pierga JY, Montoto-Grillot C, Conroy T: Efficacy and safety of bevacizumab-based combination regimens in patients with previously untreated metastatic colorectal cancer: final results from a randomised phase II study of bevacizumab plus 5-fluorouracil, leucovorin plus irinotecan versus bevacizumab plus capecitabine plus irinotecan (FNCLCC ACCORD 13/0503 study). Eur J Cancer 2013;49:1236-1245.
    • (2013) Eur J Cancer , vol.49 , pp. 1236-1245
    • Ducreux, M.1    Adenis, A.2    Pignon, J.P.3    Francois, E.4    Chauffert, B.5    Ichante, J.L.6    Boucher, E.7    Ychou, M.8    Pierga, J.Y.9    Montoto-Grillot, C.10    Conroy, T.11
  • 12
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG, et al: Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 2011;377:2103-2114.
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 13
    • 84884700039 scopus 로고    scopus 로고
    • Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): An open-label, randomised phase 3 trial
    • Cunningham D, Lang I, Marcuello E, Lorusso V, Oc-virk J, Shin DB, Jonker D, Osborne S, Andre N, Wa-terkamp D, Saunders MP: Bevacizumab plus capecitabine versus capecitabine alone in elderly patients with previously untreated metastatic colorectal cancer (AVEX): an open-label, randomised phase 3 trial. Lancet Oncol 2013;14:1077-1085.
    • (2013) Lancet Oncol , vol.14 , pp. 1077-1085
    • Cunningham, D.1    Lang, I.2    Marcuello, E.3    Lorusso, V.4    Ocvirk, J.5    Shin, D.B.6    Jonker, D.7    Osborne, S.8    Andre, N.9    Waterkamp, D.10    Saunders, M.P.11
  • 15
  • 16
    • 84883680951 scopus 로고    scopus 로고
    • Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer
    • Douillard JY, Oliner KS, Siena S, et al: Panitumumab-FOLFOX4 treatment and RAS mutations in colorectal cancer. N Engl J Med 2013;369:1023-1034.
    • (2013) N Engl J Med , vol.369 , pp. 1023-1034
    • Douillard, J.Y.1    Oliner, K.S.2    Siena, S.3
  • 20
    • 84955282009 scopus 로고    scopus 로고
    • Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours
    • Rowland A, Dias MM, Wiese MD., Kichenadasse G, McKinnon RA, Karapetis CS, Sorich MJ: Meta-analysis comparing the efficacy of anti-EGFR monoclonal antibody therapy between KRAS G13D and other KRAS mutant metastatic colorectal cancer tumours. Eur J Cancer 2016;55:122-130.
    • (2016) Eur J Cancer , vol.55 , pp. 122-130
    • Rowland, A.1    Dias, M.M.2    Wiese, M.D.3    Kichenadasse, G.4    McKinnon, R.A.5    Karapetis, C.S.6    Sorich, M.J.7
  • 21
    • 84867117207 scopus 로고    scopus 로고
    • Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab
    • Tejpar S, Celik I, Schlichting M, Sartorius U, Bokemeyer C, Van Cutsem E: Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab. J Clin Oncol 2012; 30:3570-3577.
    • (2012) J Clin Oncol , vol.30 , pp. 3570-3577
    • Tejpar, S.1    Celik, I.2    Schlichting, M.3    Sartorius, U.4    Bokemeyer, C.5    Van Cutsem, E.6
  • 22
    • 67649652208 scopus 로고    scopus 로고
    • BRAF mutation in metastatic colorectal cancer
    • Tol J, Nagtegaal ID, Punt CJ: BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009;361:98-99.
    • (2009) N Engl J Med , vol.361 , pp. 98-99
    • Tol, J.1    Nagtegaal, I.D.2    Punt, C.J.3
  • 23
    • 84883381780 scopus 로고    scopus 로고
    • Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings
    • Kubicka S, Greil R, Andre T, Bennouna J, Sastre J, Van Cutsem E, von Moos R, Osterlund P, Reyes-Rivera I, Muller T, Makrutzki M, Arnold D: Bevacizumab plus chemotherapy continued beyond first progression in patients with metastatic colorectal cancer previously treated with bevacizumab plus chemotherapy: ML18147 study KRAS subgroup findings. Ann Oncol 2013;24: 2342-2349.
    • (2013) Ann Oncol , vol.24 , pp. 2342-2349
    • Kubicka, S.1    Greil, R.2    Andre, T.3    Bennouna, J.4    Sastre, J.5    Van Cutsem, E.6    Von Moos, R.7    Osterlund, P.8    Reyes-Rivera, I.9    Muller, T.10    Makrutzki, M.11    Arnold, D.12
  • 24
    • 84939475603 scopus 로고    scopus 로고
    • Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC)
    • Heinemann V, Stintzing S, Modest DP, Giessen-Jung C, Michl M, Mansmann UR: Early tumour shrinkage (ETS) and depth of response (DpR) in the treatment of patients with metastatic colorectal cancer (mCRC). Eur J Cancer 2015;51:1927-1936.
    • (2015) Eur J Cancer , vol.51 , pp. 1927-1936
    • Heinemann, V.1    Stintzing, S.2    Modest, D.P.3    Giessen-Jung, C.4    Michl, M.5    Mansmann, U.R.6
  • 27
    • 84899900161 scopus 로고    scopus 로고
    • Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: The New EPOC randomised controlled trial
    • Primrose J, Falk S, Finch-Jones M, et al: Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial. Lancet Oncol 2014; 15:601-611.
    • (2014) Lancet Oncol , vol.15 , pp. 601-611
    • Primrose, J.1    Falk, S.2    Finch-Jones, M.3
  • 28
    • 84907027295 scopus 로고    scopus 로고
    • Maintenance strategy with fluoropyrimidines (FP) plus Bevacizumab (Bev), Bev alone, or no treatment, following a standard combination of FP, oxaliplatin (Ox), and Bev as first-line treatment for patients with metastatic colorectal cancer (mCRC): A phase III non-inferiority trial (AIO KRK 0207)
    • abstr 3503
    • Arnold D, Graeven U, Lerchenmuller C, Killing B, Depenbusch R, Steffens C-C, Al-Batran S-E, Lange T, Dietrich G, Stoehlmacher J, Tannapfel A, Schmoll HJ, Reinacher-Schick A, Hegewisch-Becker S: Maintenance strategy with fluoropyrimidines (FP) plus Bevacizumab (Bev), Bev alone, or no treatment, following a standard combination of FP, oxaliplatin (Ox), and Bev as first-line treatment for patients with metastatic colorectal cancer (mCRC): a phase III non-inferiority trial (AIO KRK 0207). J Clin Oncol 2014;32(suppl):abstr 3503.
    • (2014) J Clin Oncol , vol.32
    • Arnold, D.1    Graeven, U.2    Lerchenmuller, C.3    Killing, B.4    Depenbusch, R.5    Steffens, C.-C.6    Al-Batran, S.-E.7    Lange, T.8    Dietrich, G.9    Stoehlmacher, J.10    Tannapfel, A.11    Schmoll, H.J.12    Reinacher-Schick, A.13    Hegewisch-Becker, S.14
  • 30
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, Alberts SR, Schwartz MA, Benson AB 3rd: Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539-1544.
    • (2007) J Clin Oncol , vol.25 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6    Schwartz, M.A.7    Benson, A.B.8
  • 42
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al: Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012;366:2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 43
    • 84932628341 scopus 로고    scopus 로고
    • PD-1 blockade in tumors with mismatch-repair deficiency
    • Le DT, Uram JN, Wang H, et al: PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 2015;372:2509-2520.
    • (2015) N Engl J Med , vol.372 , pp. 2509-2520
    • Le, D.T.1    Uram, J.N.2    Wang, H.3
  • 45
    • 84908573757 scopus 로고    scopus 로고
    • FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial
    • Heinemann V, von Weikersthal LF, Decker T, et al: FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial. Lancet Oncol 2014;15:1065-1075.
    • (2014) Lancet Oncol , vol.15 , pp. 1065-1075
    • Heinemann, V.1    Von Weikersthal, L.F.2    Decker, T.3
  • 46
    • 84898666033 scopus 로고    scopus 로고
    • Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: A randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients
    • Stintzing S, Jung A, Rossius L, Modest DP, Fischer von Weikersthal L, Decker T, Möhler M, Scheithauer W, Kirchner T, Heinemann V: Analysis of KRAS/NRAS and BRAF mutations in FIRE-3: a randomized phase III study of FOLFIRI plus cetuximab or bevacizumab as first-line treatment for wild-type (WT) KRAS (exon 2) metastatic colorectal cancer (mCRC) patients. ECCO/ ESMO 2013;LBA17.
    • (2013) ECCO/ ESMO , pp. LBA17
    • Stintzing, S.1    Jung, A.2    Rossius, L.3    Modest, D.P.4    Fischer von Weikersthal, L.5    Decker, T.6    Möhler, M.7    Scheithauer, W.8    Kirchner, T.9    Heinemann, V.10
  • 47
    • 84937204003 scopus 로고    scopus 로고
    • CALGB/SWOG 80405: Phase III trial of irinotecan/5-FU/leucovorin (Folfiri) or oxaliplatin/5FU/leucovorin (mFOLFOX6) with bevacizumab (bv) or cetuximab (cet) for patients (pts) with expanded Ras analyses in untreated metastatic adenocarcinoma of the colon or rectum (MCRC)
    • Lenz HJ, et al: CALGB/SWOG 80405: phase III trial of irinotecan/5-FU/leucovorin (Folfiri) or oxaliplatin/5FU/leucovorin (mFOLFOX6) with bevacizumab (bv) or cetuximab (cet) for patients (pts) with expanded Ras analyses in untreated metastatic adenocarcinoma of the colon or rectum (MCRC). Ann Oncol 2014;25 (suppl 4):501O.
    • (2014) Ann Oncol , vol.25 , pp. 501O
    • Lenz, H.J.1
  • 48
    • 84905870196 scopus 로고    scopus 로고
    • PEAK: A randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOL-FOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer
    • Schwartzberg LS, Rivera F, Karthaus M, Fasola G, Canon JL, Hecht JR, Yu H, Oliner KS, Go WY: PEAK: a randomized, multicenter phase II study of panitumumab plus modified fluorouracil, leucovorin, and oxaliplatin (mFOLFOX6) or bevacizumab plus mFOL-FOX6 in patients with previously untreated, unresectable, wild-type KRAS exon 2 metastatic colorectal cancer. J Clin Oncol 2014;32:2240-2247.
    • (2014) J Clin Oncol , vol.32 , pp. 2240-2247
    • Schwartzberg, L.S.1    Rivera, F.2    Karthaus, M.3    Fasola, G.4    Canon, J.L.5    Hecht, J.R.6    Yu, H.7    Oliner, K.S.8    Go, W.Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.