An indirect immunofluorescence method facilitates detection of thrombospondin type 1 domain-containing 7a-specific antibodies in membranous nephropathy

Journal of the American Society of Nephrology

Volumn 28, Issue 2, 2017, Pages 520-531

  Hoxha, Elion ^a   Beck, Laurence H ^b   Wiech, Thorsten ^a   Tomas, Nicola M ^a   Probst, Christian ^c   Mindorf, Swantje ^c   Meyer Schwesinger, Catherine ^a   Zahner, Gunther ^a   Stahl, Phillip R ^a   Schöpper, Ruth ^a   Panzer, Ulf ^a   Harendza, Sigrid ^a   Helmchen, Udo ^a   Salant, David J ^b   Stahl, Rolf A K ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Institute of Experimental Immunology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; PHOSPHOLIPASE A2 RECEPTOR; PHOSPHOLIPASE A2 RECEPTOR 1; PROTEIN ANTIBODY; THROMBOSPONDIN; THROMBOSPONDIN TYPE 1 DOMAIN CONTAINING 7A; THROMBOSPONDIN TYPE 1 DOMAIN CONTAINING 7A ANTIBODY; UNCLASSIFIED DRUG; AUTOANTIBODY; THROMBOSPONDIN TYPE I DOMAIN CONTAINING 7A PROTEIN, HUMAN;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ANDROGEN DEPRIVATION THERAPY; ANTIBODY DETECTION; ARTICLE; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CHROMOSOME 7; COHORT ANALYSIS; COLON CARCINOMA; CONTROLLED STUDY; CREATININE BLOOD LEVEL; END STAGE RENAL DISEASE; ENDOMETRIUM CARCINOMA; FEMALE; FEMALE GENITAL TRACT TUMOR; FOLLICULAR DENDRITIC CELL; FOLLOW UP; GALLBLADDER CARCINOMA; GASTROINTESTINAL STROMAL TUMOR; GLOMERULUS; HEK293 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; KIDNEY BIOPSY; KIDNEY TISSUE; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MARGINAL ZONE LYMPHOMA; MEMBRANOUS GLOMERULONEPHRITIS; MINIMAL CHANGE GLOMERULONEPHRITIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROSTATE CARCINOMA; PROTEIN EXPRESSION; PROTEINURIA; REMISSION; RETROSPECTIVE STUDY; WESTERN BLOTTING; BLOOD; IMMUNOLOGY; INDIRECT FLUORESCENT ANTIBODY TECHNIQUE; MIDDLE AGED;

ADULT; AUTOANTIBODIES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLOMERULONEPHRITIS, MEMBRANOUS; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RETROSPECTIVE STUDIES; THROMBOSPONDINS;

EID: 85020111031     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2016010050     Document Type: Article

References (20)

1. Beck LH Jr., Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ: M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy. N Engl J Med 361: 11-21, 2009
2. Tomas NM, Beck LH Jr., Meyer-Schwesinger C, Seitz-Polski B, Ma H, Zahner G, Dolla G, Hoxha E, Helmchen U, Dabert-Gay AS, Debayle D, MerchantM, Klein J, SalantDJ, Stahl RA, LambeauG: Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy. N Engl J Med 371: 2277-2287, 2014
3. Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann JP, Bensman A, Deschênes G, Ronco PM: Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med 346: 2053-2060, 2002
4. Debiec H, Lefeu F, Kemper MJ, Niaudet P, Deschênes G, Remuzzi G, Ulinski T, Ronco P: Early-childhood membranous nephropathy due to cationic bovine serum albumin. N Engl J Med 364: 2101-2110, 2011
5. Prunotto M, Carnevali ML, Candiano G, Murtas C, Bruschi M, Corradini E, Trivelli A, Magnasco A, Petretto A, Santucci L, Mattei S, Gatti R, Scolari F, Kador P, Allegri L, Ghiggeri GM: Autoimmunity in membranous nephropathy targets aldose reductase and SOD2. J Am Soc Nephrol 21: 507-519, 2010
6. Hoxha E, Wiech T, Stahl PR, Zahner G, Tomas NM, Meyer-Schwesinger C, Wenzel U, Janneck M, Steinmetz OM, Panzer U, Harendza S, Stahl RA: A mechanism for cancer-associated membranous nephropathy. N Engl J Med 374: 1995-1996, 2016
7. Hoxha E, Thiele I, Zahner G, Panzer U, Harendza S, Stahl RA: Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy. J Am Soc Nephrol 25: 1357-1366, 2014
8. Hoxha E, Harendza S, Zahner G, Panzer U, Steinmetz O, Fechner K, Helmchen U, Stahl RA: An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis. Nephrol Dial Transplant 26: 2526-2532, 2011
9. Dähnrich C, Komorowski L, Probst C, Seitz-Polski B, Esnault V, Wetzels JF, Hofstra JM, Hoxha E, Stahl RA, Lambeau G, Stöcker W, Schlumberger W: Development of a standardized ELISA for the determination of autoantibodies against human M-type phospholipase A2 receptor in primarymembranous nephropathy. Clin Chim Acta 421: 213-218, 2013
10. Hofstra JM, Debiec H, Short CD, Pellé T, Kleta R, Mathieson PW, Ronco P, Brenchley PE, Wetzels JF: Antiphospholipase A2 receptor antibody titer and subclass in idiopathic membranous nephropathy. J Am Soc Nephrol 23: 1735-1743, 2012
11. Larsen CP, Cossey LN, Beck LH: THSD7A staining of membranous glomerulopathy in clinical practice reveals cases with dual autoantibody positivity. Mod Pathol 29: 421-426, 2016
12. Svobodova B, Honsova E, Ronco P, Tesar V, Debiec H: Kidney biopsy is a sensitive tool for retrospective diagnosis of PLA2R-related membranous nephropathy. Nephrol Dial Transplant 28: 1839-1844, 2013
13. Hoxha E, Kneißler U, Stege G, ZahnerG, Thiele I, Panzer U, Harendza S, Helmchen UM, Stahl RA: Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy. Kidney Int 82: 797-804, 2012
14. Aguzzi A, Kranich J, Krautler NJ: Follicular dendritic cells: Origin, phenotype, and function in health and disease. Trends Immunol 35: 105-113, 2014
15. Heesters BA, Myers RC, Carroll MC: Follicular dendritic cells: Dynamic antigen libraries. Nat Rev Immunol 14: 495-504, 2014
16. Beck LHJr., Fervenza FC, BeckDM, Bonegio RG, Malik FA, Erickson SB, Cosio FG, Cattran DC, Salant DJ: Rituximab-induced depletion of anti-PLA2R autoantibodies predicts response inmembranous nephropathy. J Am Soc Nephrol 22: 1543-1550, 2011
17. Ruggenenti P, DebiecH, Ruggiero B, Chianca A, Pellé T, Gaspari F, Suardi F, Gagliardini E, Orisio S, Benigni A, Ronco P, Remuzzi G: Antiphospholipase A2 receptor antibody titer predicts post-rituximab outcome of membranous nephropathy. J Am Soc Nephrol 26: 2545-2558, 2015
18. Kanigicherla D, Gummadova J, McKenzie EA, Roberts SA, Harris S, NikamM, Poulton K, McWilliam L, Short CD, VenningM, Brenchley PE: Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy. Kidney Int 83: 940-948, 2013
19. Lefaucheur C, Stengel B, NochyD, Martel P, HillGS, Jacquot C, Rossert J; GN-PROGRESS Study Group: Membranous nephropathy and cancer: Epidemiologic evidence and determinants of high-risk cancer association. Kidney Int 70: 1510-1517, 2006
20. Ehrenreich T, Churg J: Pathology of membranous nephropathy. Pathol Annu 3: 145-186, 1968