The small molecule IITR08027 restores the antibacterial activity of fluoroquinolones against multidrug-resistant Acinetobacter baumannii by efflux inhibition

International Journal of Antimicrobial Agents

Volumn 50, Issue 2, 2017, Pages 219-226

  Bhattacharyya, Tapas ^a   Sharma, Atin ^a   Akhter, Jawed ^a   Pathania, Ranjana ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

Author keywords

Antibiotic resistance; Clinical strains; Combination therapy; Transporters

Indexed keywords

ANTIINFECTIVE AGENT; CIPROFLOXACIN; MEPACRINE; N (3,4 DIFLUOROPHENYL) 2 [2 [3 (METHYLTHIO)PHENYLIMINO] 4 OXOTHIAZOLIDIN 5 YL]ACETAMIDE; NORFLOXACIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; ENZYME INHIBITOR; QUINOLONE DERIVATIVE;

ABEM GENE; ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; DRUG STRUCTURE; ESCHERICHIA COLI; HEK293 CELL LINE; HELA CELL LINE; MINIMUM EFFECTIVE CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; ACINETOBACTER INFECTION; ACTIVE TRANSPORT; CELL SURVIVAL; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; MOLECULAR CLONING; PRECLINICAL STUDY; PROCEDURES;

ACINETOBACTER BAUMANNII; ACINETOBACTER INFECTIONS; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CELL SURVIVAL; CIPROFLOXACIN; CLONING, MOLECULAR; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; ESCHERICHIA COLI; FLUOROQUINOLONES; GENE EXPRESSION; HEK293 CELLS; HELA CELLS; HUMANS; MEMBRANE TRANSPORT PROTEINS;

EID: 85020006375     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2017.03.005     Document Type: Article

References (31)

1. Blair, J.M.A., Webber, M.A., Baylay, A.J., Ogbolu, D.O., Piddock, L.J.V., Molecular mechanisms of antibiotic resistance. Nat Rev Microbiol 13 (2014), 42–51.
2. Piddock, L.J., Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev 19 (2006), 382–402.
3. Van Bambeke, F., Pagès, J.-M., Lee, V.J., Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux. Recent Pat Antiinfect Drug Discov 1 (2006), 157–175.
4. Marquez, B., Bacterial efflux systems and efflux pumps inhibitors. Biochimie 87 (2005), 1137–1147.
5. Coyne, S., Courvalin, P., Périchon, B., Efflux-mediated antibiotic resistance in Acinetobacter spp. Antimicrob Agents Chemother 55 (2011), 947–953.
6. Fournier, P.-E., Vallenet, D., Barbe, V., Audic, S., Ogata, H., Poirel, L., et al. Comparative genomics of multidrug resistance in Acinetobacter baumannii. PLoS Genet, 2, 2006, e7.
7. Van Looveren, M., Goossens, H., Antimicrobial resistance of Acinetobacter spp. in Europe. Clin Microbiol Infect 10 (2004), 684–704.
8. Wieczorek, P., Sacha, P., Hauschild, T., Zórawski, M., Krawczyk, M., Tryniszewska, E., Multidrug resistant Acinetobacter baumannii—the role of AdeABC (RND family) efflux pump in resistance to antibiotics. Folia Histochem Cytobiol 46 (2008), 257–267.
9. Opazo, A.C., Mella, S.M., Domínguez, M.Y., Bello, H.T., González, G.R., Multi-drug efflux pumps and antibiotic resistance in Acinetobacter baumannii. Rev Chilena Infectol 26 (2009), 499–503 in Spanish.
10. +-coupled multidrug efflux pumps from Vibrio parahaemolyticus. J Bacteriol 184 (2002), 572–576.
11. +-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters. Antimicrob Agents Chemother 49 (2005), 4362–4364.
12. Morita, Y., Kodama, K., Shiota, S., Mine, T., Kataoka, A., Mizushima, T., et al. NorM, a putative multidrug efflux protein, of Vibrio parahaemolyticus and its homolog in Escherichia coli. Antimicrob Agents Chemother 42 (1998), 1778–1782.
13. Ogawa, W., Minato, Y., Dodan, H., Onishi, M., Tsuchiya, T., Kuroda, T., Characterization of MATE-type multidrug efflux pumps from Klebsiella pneumoniae MGH78578. PLoS ONE, 10, 2015, e0121619.
14. Long, F., Rouquette-Loughlin, C., Shafer, W.M., Yu, E.W., Functional cloning and characterization of the multidrug efflux pumps NorM from Neisseria gonorrhoeae and YdhE from Escherichia coli. Antimicrob Agents Chemother 52 (2008), 3052–3060.
15. Clinical and Laboratory Standards Institute, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. 9th ed, 2012, CLSI, Wayne, PA Document M07-A9.
16. Orhan, G., Bayram, A., Zer, Y., Balci, I., Synergy tests by E test and checkerboard methods of antimicrobial combinations against Brucella melitensis. J Clin Microbiol 43 (2005), 140–143.
17. Srinivasan, V.B., Rajamohan, G., Gebreyes, W.A., Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii. Antimicrob Agents Chemother 53 (2009), 5312–5316.
18. Kodama, K., Hashimoto, A., Morita, Y., Tomochika, K., Tsuchiya, T., Preparation and characterization of everted membrane vesicles from cells of Staphylococcus aureus. Biol Pharm Bull 21 (1998), 5–9.
19. + antiporter of Vibrio parahaemolyticus. J Biochem 116 (1994), 1030–1038.
20. Nowak, J., Seifert, H., Higgins, P.G., Prevalence of eight resistance–nodulation–division efflux pump genes in epidemiologically characterized Acinetobacter baumannii of worldwide origin. J Med Microbiol 64 (2015), 630–635.
21. Kumar, A., Khan, I.A., Koul, S., Koul, J.L., Taneja, S.C., Ali, I., et al. Novel structural analogues of piperine as inhibitors of the NorA efflux pump of Staphylococcus aureus. J Antimicrob Chemother 61 (2008), 1270–1276.
22. Athamna, A., Athamna, M., Medlej, B., Bast, D.J., Rubinstein, E., In vitro post-antibiotic effect of fluoroquinolones, macrolides, β-lactams, tetracyclines, vancomycin, clindamycin, linezolid, chloramphenicol, quinupristin/dalfopristin and rifampicin on Bacillus anthracis. J Antimicrob Chemother 53 (2004), 609–615.
23. Smith, R.P., Baltch, A.L., Michelsen, P.B., Ritz, W.J., Alteri, R., Use of the microbial growth curve in postantibiotic effect studies of Legionella pneumophila. Antimicrob Agents Chemother 47 (2003), 1081–1087.
24. Drugeon, H.B., Juvin, M.E., Bryskier, A., Relative potential for selection of fluoroquinolone-resistant Streptococcus pneumoniae strains by levofloxacin: comparison with ciprofloxacin, sparfloxacin and ofloxacin. J Antimicrob Chemother 43:Suppl.C (1999), 55–59.
25. Nikhil, K., Sharan, S., Chakraborty, A., Bodipati, N., Krishna Peddinti, R., Roy, P., Role of isothiocyanate conjugate of pterostilbene on the inhibition of MCF-7 cell proliferation and tumor growth in Ehrlich ascitic cell induced tumor bearing mice. Exp Cell Res 320 (2014), 311–328.
26. Fischbach, M.A., Walsh, C.T., Antibiotics for emerging pathogens. Science 325 (2009), 1089–1093.
27. McKellar, M.R., Fendrick, A.M., Innovation of novel antibiotics: an economic perspective. Clin Infect Dis 59:Suppl. 3 (2014), S104–7.
28. Bhardwaj, A.K., Mohanty, P., Bacterial efflux pumps involved in multidrug resistance and their inhibitors: rejuvinating the antimicrobial chemotherapy. Recent Pat Antiinfect Drug Discov 7 (2012), 73–89.
29. Farha, M.A., Verschoor, C.P., Bowdish, D., Brown, E.D., Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus. Chem Biol 20 (2013), 1168–1178.
30. Hawkey, P.M., Pre-clinical experience with daptomycin. J Antimicrob Chemother 62:Suppl. 3 (2008), iii7–14.
31. Zhanel, G.G., Calic, D., Schweizer, F., Zelenitsky, S., Adam, H., Lagacé-Wiens, P.R., et al. New lipoglycopeptides. Drugs 70 (2010), 859–886.