Cost-Effectiveness of Liraglutide Versus Dapagliflozin for the Treatment of Patients with Type 2 Diabetes Mellitus in the UK

Diabetes Therapy

Volumn 8, Issue 3, 2017, Pages 513-530

  Vega Hernandez, Gabriela ^a   Wojcik, Radek ^b   Schlueter, Max ^b  

^a Novo Nordisk Ltd   (United Kingdom)

^b IQVIA   (United States)

Author keywords

Cost effectiveness analysis; Glucagon like peptide 1; Sodium glucose transporter 2; Type 2 diabetes mellitus

Indexed keywords

ACETYLSALICYLIC ACID; DAPAGLIFLOZIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN GLARGINE; LIRAGLUTIDE; METFORMIN;

ADULT; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HYPOGLYCEMIA; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PRESCRIPTION; PRIORITY JOURNAL; QUALITY ADJUSTED LIFE YEAR; RANDOMIZED CONTROLLED TRIAL; SENSITIVITY ANALYSIS; SYSTEMATIC REVIEW (TOPIC); UNITED KINGDOM;

EID: 85019724871     PISSN: 18696953     EISSN: 18696961     Source Type: Journal    
DOI: 10.1007/s13300-017-0250-y     Document Type: Article

References (55)

1. International Diabetes Federation. IDF diabetes atlas 2015. http://www.diabetesatlas.org. Accessed 18 Aug 2016.
2. Hex N, Bartlett C, Wright D, Taylor M, Varley D. Estimating the current and future costs of type 1 and type 2 diabetes in the UK, including direct health costs and indirect societal and productivity costs. Diabet Med. 2012;29(7):855–62.
3. National Institute of Health and Care Excellence (NICE). Clinical Guideline Update (NG28). Type 2 diabetes in adults: management. https://www.nice.org.uk/guidance/ng28. Accessed 18 Aug 2015.
4. Scott LJ. Liraglutide: a review of its use in adult patients with type 2 diabetes mellitus. Drugs. 2014;74(18):2161–74.
5. Ashley D, Vega G, Hunt B, Valentine WJ. Evaluating the cost-effectiveness of GLP-1 receptor agonists for the treatment of type 2 diabetes in the UK. Value Health. 2015;18(7):A606.
6. Fonseca T, Clegg J, Caputo G, Norrbacka K, Dilla T, Alvarez M. The cost-effectiveness of exenatide once weekly compared with exenatide twice daily and insulin glargine for the treatment of patients with type two diabetes and body mass index ≥30 kg/m2 in Spain. J Med Econ. 2013;16(7):926–38.
7. Huetson P, Palmer JL, Levorsen Ae, Fournier M, Germe M, McLeod E. Cost-effectiveness of once daily GLP-1 receptor agonist lixisenatide compared to bolus insulin both in combination with basal insulin for the treatment of patients with type 2 diabetes in Norway. J Med Econ. 2015;18(8):573–85.
8. McEwan P, Foos V, Palmer JL, Lamotte M, Lloyd A, Grant D. Validation of the IMS CORE Diabetes Model. Value Health. 2014;17(6):714–24.
9. Palmer AJ, Roze S, Valentine WJ, et al. The CORE Diabetes Model: projecting long-term clinical outcomes, costs and costeffectiveness of interventions in diabetes mellitus (types 1 and 2) to support clinical and reimbursement decision-making. Curr Med Res Opin. 2004;20(Suppl. 1):S5–26.
10. Palmer AJ, Roze S, Valentine WJ, et al. Validation of the CORE Diabetes Model against epidemiological and clinical studies. Curr Med Res Opin. 2004;20(sup1):S27–40.
11. Tzanetakos C, Melidonis A, Verras C, Kourlaba G, Maniadakis N. Cost-effectiveness analysis of liraglutide versus sitagliptin or exenatide in patients with inadequately controlled type 2 diabetes on oral antidiabetic drugs in Greece. BMC Health Serv Res. 2014;14(1):1.
12. Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet. 2010;375(9724):1447–56.
13. Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met + TZD). Diabetes Care. 2009;32(7):1224–30.
14. World Health Organisation. WHO Global Alcohol Report 2014: Country Profiles. http://www.who.int/entity/substance_abuse/publications/global_alcohol_report/msb_gsr_2014_2.pdf?ua=1. Accessed 1 Dec 2016.
15. Health & Social Care Information Centre (HSCIC). Statistics on smoking: England 2014. http://content.digital.nhs.uk/catalogue/PUB14988/smok-eng-2014-rep.pdf. Accessed 1 Dec 2016.
16. Lorenzi M, Ploug UJ, Langer J, Skovgaard R, Jansen J. Liraglutide versus SGLT2 inhibitors in people with type 2 diabetes: a network meta-analysis. Poster 0226-P presented at the World Diabetes Conference, 30 November–4 December 2015, Vancouver, Canada.
17. World Health Organisation. WHOCC - ATC/DDD Index. World Health Organisation. Available from: http://www.whocc.no/atc_ddd_index/?showdescription=yes&code=A10AE04. Accessed 16 Dec 2015.
18. Clarke PM, Gray AM, Briggs A, et al. A model to estimate the lifetime health outcomes of patients with type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68). Diabetologia. 2004;47(10):1747–59.
19. Joint Formulary Committee. British national formulary 71. London: BMJ Group and Pharmaceutical Press; 2016.
20. MIMS Monthly Index of Medical Specialities (MIMS). http://www.mims.co.uk/. Accessed Jun 2016.
21. Personal Social Services Research Unit. Unit costs of health and social care 2015. Personal Social Services Research Unit 2014. http://www.pssru.ac.uk/project-pages/unit-costs/2015/. Accessed Jun 2016.
22. National Institute for Health and Care Excellence. Guide to the methods of technology appraisal 2013. National Institute for Health and Care Excellence 2015. https://www.nice.org.uk/article/pmg9/chapter/foreword. Accessed 1 Dec 2016.
23. Beaudet A, Clegg J, Thuresson PO, Lloyd A, McEwan P. Review of utility values for economic modeling in type 2 diabetes. Value Health. 2014;17(4):462–70.
24. Bagust A, Beale S. Modelling EuroQol health-related utility values for diabetic complications from CODE-2 data. Health Econ. 2005;14(3):217–30.
25. Lauridsen JT, Lonborg J, Gundgaard J, Jensen HH. Diminishing marginal disutility of hypoglycaemic events: results from a time trade-off survey in five countries. Qual Life Res. 2014;23(9):2645–50.
26. Alva ML, Gray A, Mihaylova B, Leal J, Holman RR. The impact of diabetes-related complications on healthcare costs: new results from the UKPDS (UKPDS 84). Diabet Med. 2015;32(4):459–66.
27. Divino V, DeKoven M, Hallinan S, et al. Glucagon-like peptide-1 receptor agonist treatment patterns among type 2 diabetes patients in six European countries. Diabetes Ther. 2014;5(2):499–520.
28. Charokopou M, Chuang L, Verheggen B, Gibson D, Grandy S, Kartman B. Cost-effectiveness analysis of exenatide once-weekly versus dulaglutide, liraglutide and lixisenatide for the treatment of type 2 Diabetes Mellitus: an analysis from the UK NHS Perspective. Value Health. 2015;18(7):A606.
29. Scottish Medicines Consortium. Scottish Medicines Consortium liraglutide (Victoza). Scottish Medicines Consortium 2015 May 11. https://www.scottishmedicines.org.uk/SMC_Advice/Advice/1044_15_liraglutide_Victoza/liraglutide_Victoza. Accessed 9 Nov 2016.
30. Scottish Medicines Consortium. Scottish Medicines Consortium liraglutide (Victoza). Scottish Medicines Consortium 2009 December 7. http://www.scottishmedicines.org.uk/SMC_Advice/Advice/585_09_liraglutide___Victoza_/liraglutide__Victoza_. Accessed 9 Nov 2016.
31. Davies MJ, Chubb BD, Smith IC, Valentine WJ. Cost–utility analysis of liraglutide compared with sulphonylurea or sitagliptin, all as add-on to metformin monotherapy in type 2 diabetes mellitus. Diabet Med. 2012;29(3):313–20.
32. Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38(1):140–9.
33. Marso SP, Daniels GH, Brown-Frandsen K, et al. Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med. 2016;375(4):311–22.
34. Novo Nordisk. Clinical Trial Report. Liraglutide Effect and Action in Diabetes (LEAD 4): effect on glycemic control of liraglutide in combination with rosiglitazone plus metformin versus rosiglitazone plus metformin in type 2 diabetes (a twenty-six week double-blind parallel trial to investigate safety and efficacy). Trial Phase: 3a. 1-2-2008. Data on file.
35. Department of Health. NHS Reference Costs 2014 to 2015. https://www.gov.uk/government/publications/nhs-reference-costs-2014-to-2015. Accessed 1 Dec 2016.
36. National Institute of Health and Care Excellence. NICE guideline CG48: MI–secondary prevention; Secondary prevention in primary and secondary care for patients following a myocardial infarcation. National Institute of Health and Care Excellence 2007. Available from: http://www.nice.org.uk/guidance/cg48. Accessed 1 Dec 2016.
37. Cameron CG, Bennett HA. Cost-effectiveness of insulin analogues for diabetes mellitus. Can Med Assoc J. 2009;180(4):400–7.
38. Dyer MT, Goldsmith KA, Khan SN, et al. Clinical and cost-effectiveness analysis of an open label, single-centre, randomised trial of spinal cord stimulation (SCS) versus percutaneous myocardial laser revascularisation (PMR) in patients with refractory angina pectoris: the SPiRiT trial. Trials. 2008;9:40.
39. Youman P, Wilson K, Harraf F, Kalra L. The economic burden of stroke in the United Kingdom. Pharmacoeconomics. 2003;21(1):43–50.
40. National Institute of Health and Care Excellence. Chronic kidney disease: early identification and management of chronic kidney disease in adults in primary and secondary care (CG73). National Institute of Health and Care Excellence 2008. http://www.nice.org.uk/guidance/cg73. Accessed 1 Dec 2016.
41. National Institute for Health and Care Excellence. Type 2 diabetes: the management of type 2 diabetes (CG 87). National Institute for Health and Care Excellence 2014. http://www.nice.org.uk/guidance/cg87. Accessed 1 Dec 2016.
42. Chubb B, Jensen MM, Frier BM. Self-reported frequency and impact of non-severe hypoglycaemia in insulin-treated adults in the UK. Value Health. 2014;17(7):A354–5.
43. Clarke P, Gray A, Legood R, Briggs A, Holman R. The impact of diabetes-related complications on healthcare costs: results from the United Kingdom prospective diabetes study (UKPDS Study No. 65). Diabet Med. 2003;20(6):442–50.
44. Meads C, Hyde C. What is the cost of blindness? Br J Ophthalmol. 2003;87(10):1201–4.
45. Ghatnekar O, Willis M, Persson U. Cost-effectiveness of treating deep diabetic foot ulcers with Promogran in four European countries. J Wound Care. 2002;11(2):70–4.
46. Clarke P, Gray A, Holman R. Estimating utility values for health states of type 2 diabetic patients using the EQ-5D (UKPDS 62). Med Decis Mak. 2002;22(4):340–9.
47. Wasserfallen JB, Halabi G, Saudan P, et al. Quality of life on chronic dialysis: comparison between haemodialysis and peritoneal dialysis. Nephrol Dial Transpl. 2004;19(6):1594–9.
48. Kiberd BA, Jindal KK. Screening to prevent renal failure in insulin dependent diabetic patients: an economic evaluation. BMJ. 1995;311(7020):1595–9.
49. Fenwick EK, Xie J, Ratcliffe J, et al. The impact of diabetic retinopathy and diabetic macular edema on health-related quality of life in type 1 and type 2 diabetes. Investig Ophthalmol Vis Sci. 2012;53(2):677–84.
50. Lee AJ, Morgan CL, Morrissey M, Wittrup-Jensen K, Kennedy-Martin T, Currie CJ. Evaluation of the association between the EQ-5D index (health-related utility) and body mass index (obesity) in hospital-treated people with type 1 diabetes, type 2 diabetes and with no diagnosed diabetes. Diabet Med. 2005;22(11):1482–6.
51. Evans M, Khunti K, Mamdani M, et al. Health-related quality of life associated with daytime and nocturnal hypoglycaemic events: a time trade-off survey in five countries. Health Qual Life Outcomes. 2013;11(1):90.
52. Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care. 2009;32(1):84–90.
53. Bailey CJ, Gross JL, Pieters A, Bastien A, List JF. Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with metformin: a randomised, double-blind, placebo-controlled trial. Lancet. 2010;375(9733):2223–33.
54. Bolinder J, Ljunggren O, Kullberg J, et al. Effects of dapagliflozin on body weight, total fat mass, and regional adipose tissue distribution in patients with type 2 diabetes mellitus with inadequate glycemic control on metformin. J Clin Endocrinol Metab. 2012;97(3):1020–31.
55. Lambers Heerspink HJ, de ZD, Wie L, Leslie B, List J. Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes. Diabetes Obes Metab. 2013;15(9):853–62.