Virucidal activity of world health organization-recommended formulations against enveloped viruses, including zika, ebola, and emerging coronaviruses

Journal of Infectious Diseases

Volumn 215, Issue 6, 2017, Pages 902-906

  Siddharta, Anindya ^a   Pfaender, Stephanie ^e,g   Vielle, Nathalie Jane ^e,f,g   Dijkman, Ronald ^e,g   Friesland, Martina ^a   Becker, Britta ^b   Yang, Jaewon ^h   Engelmann, Michael ^a   Todt, Daniel ^a   Windisch, Marc P ^h   Brill, Florian H ^b   Steinmann, Joerg ^c   Steinmann, Jochen ^b   Becker, Stephan ^d   Alves, Marco P ^e,g   Pietschmann, Thomas ^a   Eickmann, Markus ^d   Thiel, Volker ^e,g   Steinmann, Eike ^a  

^a INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^b State Institute for Hygiene   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

^d PHILIPPS UNIVERSITY MARBURG   (Germany)

^e VETSUISSE FACULTY UNIVERSITY OF ZURICH   (Switzerland)

^f UNIVERSITY OF BERN   (Switzerland)

^g INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (Switzerland)

^h Institute Pasteur Korea   (South Korea)

Author keywords

Ebola virus; MERS; SARS; WHO; Zika virus

Indexed keywords

ANTIVIRAL ACTIVITY; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; BOVINE CORONAVIRUS; COMPARATIVE STUDY; CONTROLLED STUDY; EBOLAVIRUS; HEPATITIS C VIRUS; INFLUENZA A VIRUS (H1N1); MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; NONHUMAN; PRIORITY JOURNAL; SARS CORONAVIRUS; VIRUS ENVELOPE; VIRUS INACTIVATION; WORLD HEALTH ORGANIZATION; ZIKA VIRUS; ANTISEPSIS; CORONAVIRUS INFECTIONS; DRUG EFFECTS; HAND WASHING; HEMORRHAGIC FEVER, EBOLA; HUMAN; PRACTICE GUIDELINE; PROCEDURES; REGRESSION ANALYSIS; SEVERE ACUTE RESPIRATORY SYNDROME; SOUTH KOREA; STANDARDS; VIRULENCE; ZIKA VIRUS INFECTION;

ANTISEPSIS; CORONAVIRUS INFECTIONS; EBOLAVIRUS; HAND HYGIENE; HEMORRHAGIC FEVER, EBOLA; HUMANS; MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS; PRACTICE GUIDELINES AS TOPIC; REGRESSION ANALYSIS; REPUBLIC OF KOREA; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRULENCE; WORLD HEALTH ORGANIZATION; ZIKA VIRUS; ZIKA VIRUS INFECTION;

EID: 85019668340     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jix046     Document Type: Article

References (15)

1. World Health Organization. WHO guidelines on hand hygiene in health care: first global patient safety challenge clean care is safer care. Geneva: WHO, 2009.
2. Osterholm MT, Moore KA, Kelley NS, et al. Transmission of Ebola viruses: what we know and what we do not know. MBio 2015;6:e00137.
3. Steinmann J, Becker B, Bischoff B, et al. Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization. Am J Infect Control 2010;38:66-8.
4. Suchomel M, Rotter M. Ethanol in pre-surgical hand rubs: concentration and duration of application for achieving European Norm EN 12791. J Hosp Infect 2011;77:263-6.
5. Suchomel M, Kundi M, Pittet D, Rotter ML. Modified World Health Organization hand rub formulations comply with European efficacy requirements for preoperative surgical hand preparations. Infect Control Hosp Epidemiol 2013;34:245-50.
6. Steinmann J, Becker B, Bischoff B, Magulski T, Steinmann J, Steinmann E. Virucidal activity of formulation I of the World Health Organization's alcoholbased handrubs: impact of changes in key ingredient levels and test parameters. Antimicrob Resist Infect Control 2013;2:34.
7. Pietschmann T, Kaul A, Koutsoudakis G, et al. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc Natl Acad Sci U S A 2006;103:7408-13.
8. Eggers M, Eickmann M, Kowalski K, Zorn J, Reimer K. Povidone-iodine hand wash and hand rub products demonstrated excellent in vitro virucidal efficacy against Ebola virus and modified vaccinia virus Ankara, the new European test virus for enveloped viruses. BMC Infect Dis 2015;15:375.
9. Watt A, Moukambi F, Banadyga L, et al. A novel life cycle modeling system for Ebola virus shows a genome length-dependent role of VP24 in virus infectivity. J Virol 2014;88:10511-24.
10. Pfaender S, von Hahn T, Steinmann J, Ciesek S, Steinmann E. Prevention strategies for blood-borne viruses-in the era of vaccines, direct acting antivirals and antiretroviral therapy. Rev Med Virol 2016;26:330-9.
11. Müller JA, Harms M, Schubert A, et al. Inactivation and environmental stability of zika virus. Emerg Infect Dis 2016;22:1685-7.
12. Ciesek S, Friesland M, Steinmann J, et al. How stable is the hepatitis C virus (HCV) ? Environmental stability of HCV and its susceptibility to chemical biocides. J Infect Dis 2010;201:1859-66.
13. Centers for Disease Control and Prevention. Management of patients with suspected viral hemorrhagic fever. MMWR Suppl 1988;37:1-16.
14. Rabenau HF, Rapp I, Steinmann J. Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? BMC Infect Dis 2010;10:185.
15. Klein M, Deforest A. Antiviral action of germicides. Soap Chem Spec 1963;39:70-95.