Circulating human papillomavirus DNA detected using droplet digital PCR in the serum of patients diagnosed with early stage human papillomavirus-associated invasive carcinoma

Journal of Pathology: Clinical Research

Volumn 2, Issue 4, 2016, Pages 201-209

  Jeannot, Emmanuelle ^a   Becette, Véronique ^a   Campitelli, Maura ^a   Calméjane, Marie Ange ^a   Lappartient, Emmanuelle ^a   Ruff, Evelyne ^a   Saada, Stéphanie ^a   Holmes, Allyson ^b   Bellet, Dominique ^a   Sastre Garau, Xavier ^c  

^a INSTITUT CURIE   (France)

^b Institut Curie   (France)

^c Service d'anatomie pathologique Institut de cancérologie de Lorraine   (France)

Author keywords

Anal carcinoma; Carcinoma of the head and neck; Cervical carcinoma; Circulating HPV DNA; DdPCR

Indexed keywords

TUMOR MARKER; VIRUS DNA;

ADULT; ANUS CANCER; ARTICLE; BLOOD SAMPLING; CANCER STAGING; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; DROPLET DIGITAL POLYMERASE CHAIN REACTION; EARLY CANCER; FEMALE; GENOTYPE; HISTOPATHOLOGY; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN PAPILLOMAVIRUS TYPE 18; HUMAN TISSUE; INTERMETHOD COMPARISON; INVASIVE CARCINOMA; LIQUID BIOPSY; MAJOR CLINICAL STUDY; MALE; OROPHARYNX CANCER; PAPILLOMAVIRUS INFECTION; PLASMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; SENSITIVITY ANALYSIS; SERUM; STORAGE TEMPERATURE; TUMOR VOLUME; UTERINE CERVIX CANCER; UTERINE CERVIX CARCINOMA IN SITU; VIRUS DETECTION; VIRUS LOAD;

EID: 85019592784     PISSN: None     EISSN: 20564538     Source Type: Journal    
DOI: 10.1002/cjp2.47     Document Type: Article

References (26)

1. Schwarzenbach H, Hoon DS, Pantel K. Cell-free nucleic acids as biomarkers in cancer patients. Nat Rev Cancer 2011; 11: 426-437.
2. Diaz LA, Jr., Bardelli A. Liquid biopsies: genotyping circulating tumor DNA. J Clin Oncol 2014; 32: 579-586.
3. Diehl F, Li M, Dressman D, He Y, Shen D, Szabo S, et al. Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A 2005; 102: 16368-16373.
4. Olsson E, Winter C, George A, Chen Y, Howlin J, Tang MH, et al. Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease. EMBO Mol Med 2015; 7: 1034-1047.
5. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002; 2: 342-350.
6. Schiffman M, Castle PE, Jeronimo J, Rodriguez AC, Wacholder S. Human papillomavirus and cervical cancer. Lancet 2007; 370: 890-907.
7. Alemany L, Saunier M, Alvarado-Cabrero I, Quiros B, Salmeron J, Shin HR, et al. Human papillomavirus DNA prevalence and type distribution in anal carcinomas worldwide. Int J Cancer 2014; 136: 98-107.
8. Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol 2011; 29: 4294-4301.
9. Castellsague X. Natural history and epidemiology of HPV infection and cervical cancer. Gynecol Oncol 2008; 110: S4-S7.
10. Hopman AH, Smedts F, Dignef W, Ummelen M, Sonke G, Mravunac M, et al. Transition of high-grade cervical intraepithelial neoplasia to micro-invasive carcinoma is characterized by integration of HPV 16/18 and numerical chromosome abnormalities. J Pathol 2004; 202: 23-33.
11. Herrick J, Conti C, Teissier S, Thierry F, Couturier J, SastreGarau X, et al. Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesis. Cancer Res 2005; 65: 1174-1179.
12. Peter M, Stransky N, Couturier J, Hupe P, Barillot E, de Cremoux P, et al. Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma. J Pathol 2010; 221: 320-330.
13. Sathish N, Abraham P, Peedicayil A, Sridharan G, John S, Shaji RV, et al. HPV DNA in plasma of patients with cervical carcinoma. J Clin Virol 2004; 31: 204-209.
14. Kay P, Allan B, Denny L, Hoffman M, Williamson AL. Detection of HPV 16 and HPV 18 DNA in the blood of patients with cervical cancer. J Med Virol 2005; 75: 435-439.
15. Dong SM, Pai SI, Rha SH, Hildesheim A, Kurman RJ, Schwartz PE, et al. Detection and quantitation of human papillomavirus DNA in the plasma of patients with cervical carcinoma. Cancer Epidemiol Biomarkers Prev 2002; 11: 3-6.
16. Widschwendter A, Blassnig A, Wiedemair A, Muller-Holzner E, Muller HM, Marth C. Human papillomavirus DNA in sera of cervical cancer patients as tumor marker. Cancer Lett 2003; 202: 231-239.
17. Pornthanakasem W, Shotelersuk K, Termrungruanglert W, Voravud N, Niruthisard S, Mutirangura A. Human papillomavirus DNA in plasma of patients with cervical cancer. BMC Cancer 2001; 1: 2.
18. Yang HJ, Liu VW, Tsang PC, Yip AM, Tam KF, Wong LC, et al. Quantification of human papillomavirus DNA in the plasma of patients with cervical cancer. Int J Gynecol Cancer 2004; 14: 903-910.
19. Gnanamony M, Peedicayil A, Subhashini J, Ram TS, Rajasekar A, Gravitt P, et al. Detection and quantitation of HPV 16 and 18 in plasma of Indian women with cervical cancer. Gynecol Oncol 2010; 116: 447-451.
20. Campitelli M, Jeannot E, Peter M, Lappartient E, Saada S, de la Rochefordiere A, et al. Human papillomavirus mutational insertion: specific marker of circulating tumor DNA in cervical cancer patients. PLoS One 2012; 7: e43393.
21. Hindson CM, Chevillet JR, Briggs HA, Gallichotte EN, Ruf IK, Hindson BJ, et al. Absolute quantification by droplet digital PCR versus analog real-time PCR. Nat Methods 2013; 10: 1003-1005.
22. Rago C, Huso DL, Diehl F, Karim B, Liu G, Papadopoulos N, et al. Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer Res 2007; 67: 9364-9370.
23. Strain MC, Lada SM, Luong T, Rought SE, Gianella S, Terry VH, et al. Highly precise measurement of HIV DNA by droplet digital PCR. PLoS One 2013; 8: e55943.
24. Dahlstrom KR, Li G, Hussey CS, Vo JT, Wei Q, Zhao C, et al. Circulating human papillomavirus DNA as a marker for disease extent and recurrence among patients with oropharyngeal cancer. Cancer 2015; 121: 3455-3464.
25. Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, et al. Detection of circulating tumor DNA in early-and late-stage human malignancies. Sci Transl Med 2014; 6: 224ra224.
26. Holmes A, Lameiras S, Jeannot E, Marie Y, Castera L, SastreGarau X, et al. Mechanistic signatures of HPV insertions in cervical carcinomas. NPJ Genom Med 2016; 1: 16004.