Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn's Disease Patients with Active Mucosal Lesions

Journal of Crohn's & colitis

Volumn 11, Issue 2, 2017, Pages 221-228

  Suzuki, Kenji ^a   Yokoyama, Junji ^a   Kawauchi, Yusuke ^a   Honda, Yutaka ^a   Sato, Hiroki ^a   Aoyagi, Yutaka ^a   Terai, Shuji ^a   Okazaki, Kazuichi ^a   Suzuki, Yasuo ^a   Sameshima, Yukinori ^a   Fukushima, Tsuneo ^a   Sugahara, Kazuyuki ^a   Atreya, Raja ^a   Neurath, Markus F ^a   Watanabe, Kenichi ^a   Yoneyama, Hiroyuki ^a   Asakura, Hitoshi ^a  

^a Stelic Institute of Regenerative Medicine   (Japan)

Author keywords

CHST15; Crohn s disease; mucosal healing

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHONDROITIN SULFATE; CHST15 PROTEIN, HUMAN; GASTROINTESTINAL AGENT; MEMBRANE PROTEIN; SMALL INTERFERING RNA; SULFOTRANSFERASE;

ANTAGONISTS AND INHIBITORS; BIOPSY; BIOSYNTHESIS; CONTROLLED STUDY; CROHN DISEASE; DOSE RESPONSE; DRUG EFFECTS; DRUG MONITORING; ENDOSCOPIC MUCOSAL RESECTION; FEMALE; FIBROSIS; HUMAN; INTESTINE MUCOSA; INTRALESIONAL DRUG ADMINISTRATION; MALE; METABOLISM; PATHOLOGY; PATIENT ACUITY; PROCEDURES; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

BIOPSY; CHONDROITIN SULFATES; CROHN DISEASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; ENDOSCOPIC MUCOSAL RESECTION; FEMALE; FIBROSIS; GASTROINTESTINAL AGENTS; HUMANS; INJECTIONS, INTRALESIONAL; INTESTINAL MUCOSA; MALE; MEMBRANE GLYCOPROTEINS; OLIGORIBONUCLEOTIDES, ANTISENSE; PATIENT ACUITY; RNA, SMALL INTERFERING; SULFOTRANSFERASES; TREATMENT OUTCOME;

EID: 85018977783     PISSN: None     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjw143     Document Type: Article

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