Colonic gas homeostasis: Mechanisms of adaptation following HOST-G904 galactooligosaccharide use in humans

Neurogastroenterology and Motility

Volumn 29, Issue 9, 2017, Pages

  Mego, M ^a   Accarino, A ^a   Tzortzis, G ^b   Vulevic, J ^b   Gibson, G ^b   Guarner, F ^a   Azpiroz, F ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

diet; fiber; gut microbiota; intestinal gas; prebiotics

Indexed keywords

GALACTOSE OLIGOSACCHARIDE; PREBIOTIC AGENT;

ABDOMINAL DISCOMFORT; ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADAPTATION; ADULT; ANUS; ARTICLE; BACTERIAL METABOLISM; BLOATING; CLINICAL OUTCOME; COLON; FEMALE; FERMENTATION; FLATULENCE; GAS; HOMEOSTASIS; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; JEJUNUM; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUESTIONNAIRE; CLINICAL TRIAL; DRUG EFFECT; MIDDLE AGED;

ADAPTATION, PHYSIOLOGICAL; ADULT; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; MIDDLE AGED; PREBIOTICS;

EID: 85018851030     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/nmo.13080     Document Type: Article

References (28)

1. 2 excretion after ingestion of complex carbohydrates. Gastroenterology. 1987;92:383-389.
2. Flourie B, Leblond A, Florent C, Rautureau M, Bisalli A, Rambaud JC. Starch malabsorption and breath gas excretion in healthy humans consuming low- and high-starch diets. Gastroenterology. 1988;95:356-363.
3. Anderson IH, Levine AS, Levitt MD. Incomplete absorption of the carbohydrate in all-purpose wheat flour. N Engl J Med. 1981;304:891-892.
4. Azpiroz F. Intestinal gas. In: Feldman M, Friedman LS, Brand LJ, eds. Pathophysiology, Diagnosis, Management, 10th edn. Philadelphia, PA: Elsevier; 2015:242-250.
5. Silk DB, Davis A, Vulevic J, Tzortzis G, Gibson GR. Clinical trial: the effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacol Ther. 2009;29:508-518.
6. Mego M, Manichanh C, Accarino A, et al. Metabolic adaptation of colonic microbiota to galactooligosaccharides: a proof-of-concept-study. Aliment Pharmacol Ther. 2017;45:670-680.
7. Mego M, Bendezu A, Accarino A, Malagelada JR, Azpiroz F. Intestinal gas homeostasis: disposal pathways. Neurogastroenterol Motil. 2015;27:363-369.
8. Levitt MD. Volume and composition of human intestinal gas determined by means of an intestinal washout technique. N Engl J Med. 1971;284:1394-1398.
9. Mego M, Accarino A, Malagelada JR, Guarner F, Azpiroz F. Accumulative effect of food residues on intestinal gas production. Neurogastroenterol Motil. 2015;27:1621-1628.
10. Serra J, Azpiroz F, Malagelada J-R. Intestinal gas dynamics and tolerance in humans. Gastroenterology. 1998;115:542-550.
11. Lewis SJ, Heaton KW. Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol. 1997;32:920-924.
12. Manichanh C, Eck A, Varela E, et al. Anal gas evacuation and colonic microbiota in patients with flatulence: effect of diet. Gut. 2014;63:401-408.
13. Azpiroz F, Hernandez C, Guyonnet D, et al. Effect of a low-flatulogenic diet in patients with flatulence and functional digestive symptoms. Neurogastroenterol Motil. 2014;26:779-785.
14. Barba E, Burri E, Accarino A, et al. Abdomino-thoracic mechanisms of functional abdominal distension and correction by biofeedback. Gastroenterology. 2015;148:732-738.
15. Burri E, Barba E, Huaman JW, et al. Mechanisms of postprandial abdominal bloating and distension in functional dyspepsia. Gut. 2014;63:395-400.
16. Malagelada C, Drozdzal M, Segui S, et al. Classification of functional bowel disorders by objective physiological criteria based on endoluminal image analysis. Am J Physiol Gastrointest Liver Physiol. 2015;309:G413-G419.
17. Malagelada C, Barba I, Accarino A, et al. Cognitive and hedonic responses to meal ingestion correlate with changes in circulating metabolites. Neurogastroenterol Motil. 2016;28:1806-1814.
18. Malagelada C, Accarino A, Molne L, et al. Digestive, cognitive and hedonic responses to a meal. Neurogastroenterol Motil. 2015;27:389-396.
19. Serra J, Azpiroz F, Malagelada J-R. Gastric distension and duodenal lipid infusion modulate intestinal gas transit and tolerance in humans. Am J Gastroenterol. 2002;97:2225-2230.
20. Serra J, Azpiroz F, Malagelada J-R. Mechanisms of intestinal gas retention in humans:impaired propulsion versus obstructed evacuation. Am J Physiol. 2001;281:G138-G143.
21. Serra J, Azpiroz F, Malagelada J-R. Impaired transit and tolerance of intestinal gas in the irritable bowel syndrome. Gut. 2001;48:14-19.
22. Serra J, Salvioli B, Azpiroz F, Malagelada JR. Lipid-induced intestinal gas retention in the irritable bowel syndrome. Gastroenterology. 2002;123:700-706.
23. Hernando-Harder AC, Serra J, Azpiroz F, et al. Colonic responses to gas loads in subgroups of patients with abdominal bloating. Am J Gastroenterol. 2010;105:876-882.
24. Oku T, Nakamura S. Comparison of digestibility and breath hydrogen gas excretion of fructo-oligosaccharide, galactosyl-sucrose, and isomalto-oligosaccharide in healthy human subjects. Eur J Clin Nutr. 2003;57:1150-1156.
25. Passos MC, Tremolaterra F, Serra J, Azpiroz F, Malagelada J-R. Impaired reflex control of intestinal gas transit in patients with abdominal bloating. Gut. 2005;54:344-348.
26. Salvioli B, Serra J, Azpiroz F, et al. Origin of gas retention and symptoms in patients with bloating. Gastroenterology. 2005;128:574-579.
27. Caldarella MP, Serra J, Azpiroz F, Malagelada JR. Prokinetic effects in patients with intestinal gas retention. Gastroenterology. 2002;122:1748-1755.
28. Major G, Pritchard S, Murray K, et al. Colon hypersensitivity to distension, rather than excessive gas production, produces carbohydrate-related symptoms in individuals with irritable bowel syndrome. Gastroenterology. 2017;152:124-133.