Nicotine, aerosol particles, carbonyls and volatile organic compounds in tobacco- and menthol-flavored e-cigarettes

Environmental Health: A Global Access Science Source

Volumn 16, Issue 1, 2017, Pages

  Lee, Mi Sun ^a   LeBouf, Ryan F ^b   Son, Youn Suk ^c   Koutrakis, Petros ^a   Christiani, David C ^a,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c Korea Atomic Energy Research Institute   (South Korea)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Carbonyls; Nicotine; Particles; VOCs in e cigarette emissions

Indexed keywords

BENZENE; CARBONYL DERIVATIVE; MENTHOL; NANOPARTICLE; NICOTINE; TOBACCO SMOKE; TOLUENE; TRACE ELEMENT; VOLATILE ORGANIC COMPOUND; AEROSOL; AIR POLLUTANT; ELEMENT; PARTICULATE MATTER;

AEROSOL; CARBONYL COMPOUND; CONCENTRATION (COMPOSITION); DRUG; INDOOR AIR; MACHINERY; RESEARCH WORK; SMOKING; TOXIC SUBSTANCE; VOLATILE ORGANIC COMPOUND;

ARTICLE; CARBON FOOTPRINT; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); DILUTION; ELECTRONIC CIGARETTE; ENVIRONMENTAL EXPOSURE; LIQUID; SMOKING; SOLID; SPECTROSCOPY; TOBACCO; AEROSOL; AIR POLLUTANT; ANALYSIS; PARTICULATE MATTER;

NICOTIANA TABACUM;

AEROSOLS; AIR POLLUTANTS; ELECTRONIC CIGARETTES; ELEMENTS; MENTHOL; NANOPARTICLES; NICOTINE; PARTICULATE MATTER; TOBACCO; VOLATILE ORGANIC COMPOUNDS;

EID: 85018849025     PISSN: None     EISSN: 1476069X     Source Type: Journal    
DOI: 10.1186/s12940-017-0249-x     Document Type: Article

References (50)

1. Schripp T, Markewitz D, Uhde E, Salthammer T (2013) Does e-cigarette consumption cause passive vaping? Indoor Air 23(1):25-31
2. Cheng T (2014) Chemical evaluation of electronic cigarettes. Tob Control 23:ii11-ii17
3. Grana R, Benowitz N, Glantz SA (2014) E-cigarettes: a scientific review. Circulation 129(19):1972-1986
4. Fuoco FC, Buonanno G, Stabile L, Vigo P (2014) Influential parameters on particle concentration and size distribution in the mainstream of e-cigarettes. Environ Pollut 184:523-529
5. Goniewicz ML, Knysak J, Gawron M, Kosmider L, Sobczak A, Kurek J et al (2014) Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control 23(2):133-139
6. Fernández E, Ballbè M, Sureda X, Fu M, Saltó E, Martínez-Sánchez JM (2015) Particulate matter from electronic cigarettes and conventional cigarettes: a systematic review and observational study. Curr Environ Health Rep 2(4):423-9
7. Pankow JF, Kim K, McWhirter KJ, Luo W, Escobedo JO, Strongin RM, Duell AK, Peyton DH (2017) Benzene formation in electronic cigarettes. PLoS One 12(3):e0173055
8. Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P (2013) Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PloS one 8(3):e57987
9. Giovenco DP, Hammond D, Corey CG, Ambrose BK, Delnevo CD (2015) E-cigarette market trends in traditional U.S. retail channels, 2012-2013. Nicotine Tob Res 17(10):1279-1283
10. Farsalinos KE, Spyrou A, Tsimopoulou K, Stefopoulos C, Romagna G, Voudris V (2014) Nicotine absorption from electronic cigarette use: comparison between first and new-generation devices. Sci Rep 4:4133
11. European Commission (2013) Revision of the tobacco products directive-press release (European parliament)., Available at: http://www.europarl.europa.eu/pdfs/news/expert/infopress/20131216IPR31001/20131216IPR31001-en.pdf
12. Turner S, Cyr L, Gross AJ (1992) The measurement of environmental tobacco-smoke in 585 office environments. Environ Int 18(1):19-28
13. Baek SO, Kim YS, Perry R (1997) Indoor air quality in homes, offices and restaurants in Korean urban areas - Indoor/outdoor relationships. Atmos Environ 31(4):529-544
14. Butz AM, Breysse P, Rand C, Curtin-Brosnan J, Eggleston P, Diette GB et al (2011) Household smoking behavior: effects on indoor air quality and health of urban children with asthma. Matern Child Health J 15(4):460-468
15. Sureda X, Martinez-Sanchez JM, Lopez MJ, Fu M, Aguero F, Salto E et al (2012) Secondhand smoke levels in public building main entrances: outdoor and indoor PM2.5 assessment. Tob Control 21(6):543-548
16. Geiss O, Bianchi I, Barahona F, Barrero-Moreno J (2015) Characterisation of mainstream and passive vapours emitted by selected electronic cigarettes. Int J Hyg Environ Health 218(1):169-180
17. Morabia A, Amstislavski PN, Mirer FE, Amstislavski TM, Eisl H, Wolff MS et al (2009) Air pollution and activity during transportation by car, subway, and walking. Am J Prev Med 37(1):72-77
18. Zhu K, Zhang J, Lioy PJ (2007) Evaluation and comparison of continuous fine particulate matter monitors for measurement of ambient aerosols. J Air Waste Manag Assoc 57(12):1499-1506
19. Colton MD, MacNaughton P, Vallarino J, Kane J, Bennett-Fripp M, Spengler JD, Adamkiewicz G (2014) Indoor air quality in green vs conventional multifamily low-income housing. Environ Sci Technol 48:7833-7841
20. LeBouf RF, Stefaniak AB, Virji MA (2012) Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings. J Environ Monit 14(3):977-983
21. IARC. IARC Monograph 71: re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. 1999. Available at: http://monographs.iarc.fr/ENG/Monographs/vol71/mono71.pdf. Accessed date 19 Oct 2016.
22. IARC. IARC Monograph 100 F: Chemical Agents and Related Occupations, p. 249-294. 2012. Available at: http://monographs.iarc.fr/ENG/Monographs/vol100F/mono100F.pdf. Accessed 19 Oct 2016.
23. 2.5 levels. Environ Sci Tech 48:12150-12156
24. Fu M, Martinez-Sanchez JM, Galan I, Perez-Rios M, Sureda X, Lopez MJ et al (2013) Variability in the correlation between nicotine and PM2.5 as airborne markers of second-hand smoke exposure. Environ Res 127:49-55
25. Schober W, Szendrei K, Matzen W, Osiander-Fuchs H, Heitmann D, Schettgen T et al (2014) Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int J H Environ Health 217(6):628-637
26. Ji EH, Sun BB, Zhao TK, Shu S, Chang CH, Messadi D et al (2016) Characterization of electronic cigarette aerosol and its induction of oxidative stress response in oral keratinocytes. PloS one 11(5):e0154447
27. Mikheev VB, Brinkman MC, Granville CA, Gordon SM, Clark PI (2016) Real-time measurement of electronic cigarette aerosol size distribution and metals content analysis. Nicotine Tob Res 18(9):1895-902
28. Ingebrethsen BJ, Cole SK, Alderman SL (2012) Electronic cigarette aerosol particle size distribution measurements. Inhal Toxol 24(14):976-984
29. Bakand S, Hayes A, Dechsakulthorn F (2012) Nanoparticles: a review of particle toxicology following inhalation exposure. Inhal Toxicol 24(2):125-135
30. Oberdorster G, Oberdorster E, Oberdorster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823-839
31. Terzano C, Di Stefano F, Conti V, Graziani E, Petroianni A (2010) Air pollution ultrafine particles: toxicity beyond the lung. Eur Rev Med Pharmacol Sci 14(10):809-821
32. Burstyn I (2014) Peering through the mist: systematic review of what the chemistry of contaminants in electronic cigarettes tells us about health risks. BMC Public Health 14:18
33. st Edition. From contents to chemical and particle exposure profiles. Cambridge: Elsevier; 2016.
34. U.S. EPA. Health Assessment Document for Acetaldehyde. EPA/600/8-86-015A. Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, office of Research and Development, Research Triangle Park, NC. 1987.
35. Lambert B, He SM (1988) DNA and chromosome damage induced by acetaldehyde in human lymphocytes in vitro. Ann N Y Acad Sci 534:369-376
36. Singh NP, Khan A (1995) Acetaldehyde: genotoxicity and cytotoxicity in human lymphocytes. Mutat Res 337(1):9-17
37. Blasiak J, Trzeciak A, Malecka-Panas E, Drzewoski J, Wojewodzka M (2000) In vitro genotoxicity of ethanol and acetaldehyde in human lymphocytes and the gastrointestinal tract mucosa cells. Toxicol In Vitro 14(4):287-295
38. Bekki K, Uchiyama S, Ohta K, Inaba Y, Nakagome H, Kunugita N (2014) Carbonyl compounds generated from electronic cigarettes. Int J Environ Res Public Health 11(11):11192-11200
39. Farsalinos KE, Voudris V, Poulas K (2015) E-cigarettes generate high levels of aldehydes only in 'dry puff' conditions. Addiction 110(8):1352-1356
40. McAuley TR, Hopke PK, Zhao J, Babaian S (2012) Comparison of the effects of e-cigarette vapor and cigarette smoke on indoor air quality. Inhal Toxicol 24(12):850-857
41. OSHA. Air Contaminants. 29 CFR 1910.1000 [71 FR 16673, April 3, 2006]. 2016. Web site: https://www.osha.gov/dsg/annotated-pels/tablez-1.html, Accessed on 30 Jan 2012
42. NIOSH. NIOSH pocket guide to chemical hazards. Department of Health and Human Services. Centers for Disease Control and Prevention. Web site last updated on May 18, 2016. DHHS (NIOSH) Publication No. 2005-149. 2007. http://www.cdc.gov/niosh/docs/2005-149/pdfs/2005-149.pdf
43. ACGIH. Threshold Limit Values for Chemical Substances in the Work Environment. Adopted by ACGIH® with Intended Changes. 2016. store/ProductFormPublic/search?action=1&Product-categories-Checkboxes=2/store/ProductFormPublic/search?action=1&Product-categories-Checkboxes=2
44. 2.5) National Ambient Air Quality Standards (NAAQS). https://www.epa.gov/pm-pollution/table-historical-particulate-matter-pm-national-ambient-air-quality-standards-naaqs. Accessed 19 Apr 2017.
45. WHO. Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide - Global update 2005 - Summary of risk assessment. 2005. http://apps.who.int/iris/bitstream/10665/69477/1/WHO-SDE-PHE-OEH-06.02-eng.pdf
46. EU. Directive 2008/50/EC of the European Parliament and of the Council of 21 May 2008 on ambient air quality and cleaner air for Europe (OJ L 152, 11.6.2008, p. 1-44). 2008. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2008:152:0001:0044:EN:PDF
47. European Environment Agency (EEA). Air quality in Europe - 2015 report. http://www.eea.europa.eu/publications/air-quality-in-europe-2015. Accessed 19 Apr 2017.
48. Castorina R, Woodruff TJ (2003) Assessment of potential risk levels associated with U.S. Environmental protection agency reference values. Environ Health Perspect 111(10):1318-1325
49. Czogala J, Goniewicz ML, Fidelus B, Zielinska-Danch W, Travers MJ, Sobczak A (2014) Secondhand exposure to vapors from electronic cigarettes. Nicotine Tob Res 16:655-662
50. Uchiyama S, Ohta K, Inaba Y, Kunugita N (2013) Determination of carbonyl compounds generated from the e-cigarette using coupled silica cartridges impregnated with hydroquinone and 2,4-dinitrophenylhydrazine, followed by high-performance liquid chromatography. Anal Sci 29(12):1219-1222