Resuscitation with Balanced Fluids Is Associated with Improved Survival in Pediatric Severe Sepsis

Critical Care Medicine

Volumn 45, Issue 7, 2017, Pages 1177-1183

  Emrath, Elizabeth T ^a   Fortenberry, James D ^a,b   Travers, Curtis ^a   McCracken, Courtney E ^a   Hebbar, Kiran B ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

Author keywords

fluid therapy; isotonic solutions; mortality; pediatric; severe sepsis

Indexed keywords

BALANCED FLUID; ISOTONIC SOLUTION; UNCLASSIFIED DRUG; VASOACTIVE AGENT; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ACUTE KIDNEY FAILURE; ADOLESCENT; ADULT; CHILD; CHILDHOOD DISEASE; CHILDHOOD MORTALITY; CLINICAL OUTCOME; CONFERENCE PAPER; CONTROLLED STUDY; DRUG INFUSION; FEMALE; FLUID RESUSCITATION; HOSPITAL MORTALITY; HUMAN; INFANT; INTENSIVE CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY RATE; NEWBORN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEPSIS; SURVIVAL; TREATMENT DURATION; ACUTE KIDNEY INJURY; CLINICAL TRIAL; COMPLICATION; FLUID THERAPY; MORTALITY; MULTICENTER STUDY; PEDIATRIC INTENSIVE CARE UNIT; PRESCHOOL CHILD; PREVALENCE; PROCEDURES; RESUSCITATION; STATISTICS AND NUMERICAL DATA;

ACUTE KIDNEY INJURY; ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; FLUID THERAPY; HOSPITAL MORTALITY; HUMANS; INFANT; INFANT, NEWBORN; INTENSIVE CARE UNITS, PEDIATRIC; MALE; PREVALENCE; RESUSCITATION; RETROSPECTIVE STUDIES; SEPSIS; VASOCONSTRICTOR AGENTS; VASODILATOR AGENTS;

EID: 85018818820     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000002365     Document Type: Conference Paper

References (31)

1. Ruth A McCracken CE Fortenberry JD. Pediatric severe sepsis: Current trends and outcomes from the Pediatric Health Information Systems database. Pediatr Crit Care Med 2014; 15: 828 838
2. Stewart PA. Modern quantitative acid-base chemistry. Can J Physiol Pharmacol 1983; 61: 1444 1461
3. Morgan TJ. The ideal crystalloid-what is 'balanced'? Curr Opin Crit Care 2013; 19: 299 307
4. Raghunathan K Nailer P Konoske R. What is the ideal crystalloid? Curr Opin Crit Care 2015; 21: 309 314
5. Dellinger RP Levy MM Rhodes A; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med 2013; 41: 580 637
6. Brierley J Carcillo JA Choong K. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med 2009; 37: 666 688
7. Raghunathan K Shaw A Nathanson B. Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis. Crit Care Med 2014; 42: 1585 1591
8. Shaw AD Schermer CR Lobo DN. Impact of intravenous fluid composition on outcomes in patients with systemic inflammatory response syndrome. Crit Care 2015; 19: 334
9. Mongelluzzo J Mohamad Z Ten Have TR. Corticosteroids and mortality in children with bacterial meningitis. JAMA 2008; 299: 2048 2055
10. Angus DC Linde-Zwirble WT Lidicker J. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303 1310
11. Weiss SL Parker B Bullock ME. Defining pediatric sepsis by different criteria: Discrepancies in populations and implications for clinical practice. Pediatr Crit Care Med 2012; 13: e219 e226
12. Feudtner C Christakis DA Connell FA. Pediatric deaths attributable to complex chronic conditions: A population-based study of Washington state, 1980-1997. Pediatrics 2000; 106: 205 209
13. Dellinger RP Carlet JM Masur H; Surviving Sepsis Campaign Management Guidelines Committee: Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32: 858 873
14. Young P Bailey M Beasley R. Effect of a buffered crystalloid solution vs saline on acute kidney injury among patients in the intensive care unit: The SPLIT randomized clinical trial. JAMA 2015; 314: 1701 1710
15. Parker MM Shelhamer JH Natanson C. Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 1987; 15: 923 929
16. Ceneviva G Paschall JA Maffei F. Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics 1998; 102: e19
17. Carcillo JA Cunnion RE. Septic shock. Crit Care Clin 1997; 13: 553 574
18. Goldstein B Giroir B Randolph A. International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6: 2 8
19. Yunos NM Bellomo R Hegarty C. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 2012; 308: 1566 1572
20. Shaw AD Bagshaw SM Goldstein SL. Major complications, mortality, and resource utilization after open abdominal surgery: 0.9% saline compared to Plasma-Lyte. Ann Surg 2012; 255: 821 829
21. Yunos NM Bellomo R Story D. Bench-to-bedside review: Chloride in critical illness. Crit Care 2010; 14: 226
22. Neyra JA Canepa-Escaro F Li X; Acute Kidney Injury in Critical Illness Study Group: Association of hyperchloremia with hospital mortality in critically ill septic patients. Crit Care Med 2015; 43: 1938 1944
23. Shaw AD Raghunathan K Peyerl FW. Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. Intensive Care Med 2014; 40: 1897 1905
24. O'Dell E Tibby SM Durward A. Hyperchloremia is the dominant cause of metabolic acidosis in the postresuscitation phase of pediatric meningococcal sepsis. Crit Care Med 2007; 35: 2390 2394
25. Foland JA Fortenberry JD Warshaw BL. Fluid overload before continuous hemofiltration and survival in critically ill children: A retrospective analysis. Crit Care Med 2004; 32: 1771 1776
26. Arikan AA Zappitelli M Goldstein SL. Fluid overload is associated with impaired oxygenation and morbidity in critically ill children. Pediatr Crit Care Med 2012; 13: 253 258
27. Singer M Deutschman CS Seymour CW. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315: 801 810
28. Vlasschaert ME Bejaimal SA Hackam DG. Validity of administrative database coding for kidney disease: A systematic review. Am J Kidney Dis 2011; 57: 29 43
29. Siew ED Basu RK Wunsch H. Optimizing administrative datasets to examine acute kidney injury in the era of big data: Workgroup statement from the 15(th) ADQI Consensus Conference. Can J Kidney Health Dis 2016; 3: 12
30. Schaffzin JK Dodd CN Nguyen H. Administrative data misclassifies and fails to identify nephrotoxin-associated acute kidney injury in hospitalized children. Hosp Pediatr 2014; 4: 159 166
31. Austin PC Mamdani MM Stukel TA. The use of the propensity score for estimating treatment effects: Administrative versus clinical data. Stat Med 2005; 24: 1563 1578