Toll-Like Receptor 4 Mediates Hemorrhagic Transformation after Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke

Stroke

Volumn 48, Issue 6, 2017, Pages 1695-1699

  García Culebras, Alicia ^a   Palma Tortosa, Sara ^a   Moraga, Ana ^a   García Yébenes, Isaac ^a   Durán Laforet, Violeta ^a   Cuartero, Maria I ^a   De La Parra, Juan ^a   Barrios Muñoz, Ana L ^a   Díaz Guzmán, Jaime ^a   Pradillo, Jesús M ^a   Moro, María A ^a   Lizasoain, Ignacio ^a  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

Author keywords

blood brain barrier; hemorrhage; inflammation; middle cerebral artery; stroke

Indexed keywords

ALTEPLASE; GELATINASE B; TOLL LIKE RECEPTOR 4; FIBRINOLYTIC AGENT; TISSUE PLASMINOGEN ACTIVATOR; TLR4 PROTEIN, MOUSE;

ADVERSE DRUG REACTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLEEDING; BRAIN ISCHEMIA; CONTROLLED STUDY; FIBRINOLYTIC THERAPY; HEMORRHAGIC TRANSFORMATION; MIDDLE CEREBRAL ARTERY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION; THROMBOEMBOLISM; ANIMAL; BRAIN EMBOLISM; BRAIN HEMORRHAGE; C57BL MOUSE; CEREBRAL ARTERY DISEASE; CEREBRAL INFARCTION; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; METABOLISM; OCCLUSIVE CEREBROVASCULAR DISEASE; STROKE; TIME FACTOR; TRANSGENIC MOUSE;

ANIMALS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; FIBRINOLYTIC AGENTS; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRACRANIAL EMBOLISM; INTRACRANIAL THROMBOSIS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; STROKE; TIME FACTORS; TISSUE PLASMINOGEN ACTIVATOR; TOLL-LIKE RECEPTOR 4;

EID: 85018805283     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.116.015956     Document Type: Article

References (13)

1. Goyal M, Menon BK, van Zwam WH, Dippel DW, Mitchell PJ, Demchuk AM, HERMES collaborators Endovascular thrombectomy after large-vessel ischaemic stroke: A meta-Analysis of individual patient data from five randomised trials. Lancet 2016 387 1723 1731. doi: 10.1016/S0140-6736(16)00163-X
2. Lo EH, A new penumbra: Transitioning from injury into repair after stroke. Nat Med 2008 14 497 500. doi: 10.1038/nm1735
3. Rosenberg GA, Estrada EY, Dencoff JE, Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain. Stroke 1998 29 2189 2195
4. Qiu J, Xu J, Zheng Y, Wei Y, Zhu X, Lo EH, High-mobility group box 1 promotes metalloproteinase-9 upregulation through toll-like receptor 4 after cerebral ischemia. Stroke 2010 41 2077 2082. doi: 10.1161/STROKEAHA.110.590463
5. Caso JR, Pradillo JM, Hurtado O, Lorenzo P, Moro MA, Lizasoain I, Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke. Circulation 2007 115 1599 1608. doi: 10.1161/CIRCULATIONAHA.106.603431
6. Castellanos M, Leira R, Serena J, Pumar JM, Lizasoain I, Castillo J, Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 2003 34 40 46
7. Yang QW, Wang JZ, Li JC, Zhou Y, Zhong Q, Lu FL, High-mobility group protein box-1 and its relevance to cerebral ischemia. J Cereb Blood Flow Metab 2010 30 243 254. doi: 10.1038/jcbfm.2009.202
8. Teng W, Wang L, Xue W, Guan C, Activation of TLR4-mediated NFkappaB signaling in hemorrhagic brain in rats. Mediators Inflamm 2009 2009 473276. doi: 10.1155/2009/473276
9. Fang H, Wang PF, Zhou Y, Wang YC, Yang QW, Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury. J Neuroinflammation 2013 10 27. doi: 10.1186/1742-2094-10-27
10. Sansing LH, Harris TH, Welsh FA, Kasner SE, Hunter CA, Kariko K, Toll-like receptor 4 contributes to poor outcome after intracerebral hemorrhage. Ann Neurol 2011 70 646 656. doi: 10.1002/ana.22528
11. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med 2003 9 1313 1317. doi: 10.1038/nm926
12. Leow-Dyke S, Allen C, Denes A, Nilsson O, Maysami S, Bowie AG, Neuronal toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. J Neuroinflammation 2012 9 230. doi: 10.1186/1742-2094-9-230
13. Rosell A, Cuadrado E, Ortega-Aznar A, Hernández-Guillamon M, Lo EH, Montaner J, MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke 2008 39 1121 1126. doi: 10.1161/STROKEAHA.107.500868.